Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples.
PMID 41759529 · PMC13036604 · Molecular cell · 2026 · 8 claims · 8 setups
An optimized dual-lentiviral CRISPR-Cas9 knockout system with fluorescent markers, SFFV promoter, and improved sgRNA backbone (LRG2.1) achieves efficient, low-toxicity gene editing in AML PDX and primary patient samples
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Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity.
PMID 41842971 · PMC13132380 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups
PRC2i/EZH2i alone or combined with AR inhibitors induce diverse cell state programs (CSPs) that increase tumor cell invasion, metastasis, and drug resistance despite only modest suppression of tumor growth.
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MECOM Function Is Critical for AR-Driven Treatment-Resistant Prostate Cancer.
PMID 41529070 · PMC13136877 · Cancer research · 2026 · 7 claims · 8 setups
EVI1, encoded by MECOM, is an AR-recruited coactivator of noncanonical AR signaling in prostate cancer.
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Synergistic targeting of eIF4A-mediated translation initiation and apoptosis in acute myeloid leukemia.
PMID 41815287 · PMC12971725 · Blood neoplasia · 2026 · 8 claims · 8 setups
EIF4A1 is highly expressed in AML stem- and progenitor-like cells relative to healthy hematopoietic stem/progenitor cells