Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 21

System / cell line: real ✕ Assay: flow ✕ Clear

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.

PMID 12925705 · PMC2173788 · The Journal of cell biology · 2003 · 7 claims · 8 setups

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CENP-E-null cells cannot sustain a mitotic checkpoint arrest in response to one or a few unattached kinetochores, causing cells to enter anaphase with missegregating chromosomes and become aneuploid

embryonic mefs hepatocytes bubr1 real-time quantitative immunofluorescence
miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes.

PMID 18029362 · PMC2238982 · Nucleic acids research · 2008 · 8 claims · 6 setups

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miRNAMap 2.0 is a resource collecting experimentally verified miRNAs and experimentally verified miRNA target genes in human, mouse, rat and other metazoan genomes

major tissues conserved predicted quantitative bead-based microarray
Reduced transcription of TCOF1 in adult cells of Treacher Collins syndrome patients.

PMID 20003452 · PMC2801500 · BMC medical genetics · 2009 · 8 claims · 5 setups

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TCOF1 transcript levels are significantly reduced (~18%) in leucocytes of TCS patients compared to controls

leucocytes mesenchymal leucocyte real-time direct flow
Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay.

PMID 16507671 · PMC1385994 · Nucleic acids research · 2006 · 8 claims · 6 setups

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Gamma radiation increases L1 retrotransposition frequency in cultured cells

143b cho-k1 retrotransposition immunofluorescence quantitative
The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells.

PMID 15661077 · PMC548512 · Respiratory research · 2005 · 6 claims · 3 setups

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IL-13 and IL-13R130Q modulate the same set of genes in human airway smooth muscle cells (HASMC)

airway hasmc cdna taqman flow
Improved tagging strategy for protein identification in mammalian cells.

PMID 16138932 · PMC1250225 · BMC genomics · 2005 · 7 claims · 7 setups

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EGFP tagging via the artificial exon did not affect the subcellular localization of the tagged endogenous proteins

osteosarcoma hos 293t lentiviral flow confocal
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.

PMID 19109564 · PMC2680375 · Blood · 2009 · 8 claims · 6 setups

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Zebrafish morpholino knockdown combined with a laser-induced arterial thrombosis assay is a fast, powerful method for initial functional screening of novel platelet genes.

blood platelets platelet-rich platelet whole-genome quantitative flow
Association between telomere length and V(H) gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications.

PMID 12592375 · PMC2377180 · British journal of cancer · 2003 · 7 claims · 5 setups

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Unmutated VH gene CLL cases have significantly shorter telomeres than mutated VH gene CLL cases

cll subset pcr southern real-time
CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas.

PMID 18577749 · PMC2483574 · Journal of the National Cancer Institute · 2008 · 7 claims · 8 setups

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CHD5 promoter is highly methylated in neuroblastoma cell lines with 1p deletion and absent CHD5 expression (NLF, IMR5)

neuroblastoma nlf athymic methylation-specific quantitative soft
Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach.

PMID 18523666 · PMC2408776 · Molecular vision · 2008 · 7 claims · 5 setups

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Copine1 mRNA and protein expression are upregulated in glaucomatous TM (GTM) cells compared to normal TM (NTM) cells

trabecular ntm 2-d immunocytochemistry quantitative
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.

PMID 18523662 · PMC2408759 · PloS one · 2008 · 8 claims · 8 setups

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Mature human erythrocytes lack ribosomal/large RNAs but contain abundant and diverse microRNAs

mature erythrocytes k562 erythrocyte microrna size northern
Interaction of vitamin D receptor with HLA DRB1 0301 in type 1 diabetes patients from North India.

PMID 19956544 · PMC2780726 · PloS one · 2009 · 8 claims · 6 setups

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Interaction between VDR and HLA alleles is mediated by a VDRE present in the promoter region of HLA-DRB1*0301, which may be detrimental in the absence of 1,25-(OH)2D3 in early childhood.

blood genotype hla-drb1*0301 drb1*0301-carrying pcr-rflp pcr haplotype
A homozygous CARD9 mutation in a family with susceptibility to fungal infections.

PMID 19864672 · PMC2793117 · The New England journal of medicine · 2009 · 7 claims · 7 setups

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A homozygous CARD9 point mutation (Q295X, premature termination codon) is associated with autosomal recessive susceptibility to chronic mucocutaneous candidiasis.

family patients peripheral-blood peripheral snp microsatellite sanger
Identification of transcription start sites and preferential expression of select CB2 transcripts in mouse and human B lymphocytes.

PMID 19757078 · PMC2843092 · Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009 · 7 claims · 8 setups

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Human B cells express one CB2 transcript while mouse B cells express three CB2 transcripts

splenocytes pbmc-derived splenic genbank race pcr quantitative
miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1.

PMID 36130054 · PMC9897280 · Spine · 2023 · 7 claims · 8 setups

Has reproduction · 100

miR-4478 is upregulated in nucleus pulposus tissues from IVDD patients and is degeneration-degree-associated

annulus tissues npcs mirna quantitative fluorescence
Weighted gene co-expression network analysis reveals that CXCL10, IRF7, MX1, RSAD2, and STAT1 are related to the chronic stage of spinal cord injury.

PMID 34532385 · PMC8421925 · Annals of translational medicine · 2021 · 8 claims · 7 setups

Has reproduction · 44

The brown co-expression module (775 genes) is the module most significantly associated with the chronic stage of SCI

spinal brown sci microarray functional protein-protein
CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

PMID 16892042 · PMC2360640 · British journal of cancer · 2006 · 6 claims · 6 setups

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CD70 was identified by proteomic analysis of plasma membrane preparations as highly expressed in A498 and SW839 RCC-derived cell lines

a498 frozen normal proteomics flow immunohistochemistry
Statistical learning of peptide retention behavior in chromatographic separations: a new kernel-based approach for computational proteomics.

PMID 18053132 · PMC2254445 · BMC bioinformatics · 2007 · 6 claims · 5 setups

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The paired oligo-border kernel (POBK) combined with SVMs predicts peptide adsorption/elution in SAX-SPE and retention time in IP-RP-HPLC more accurately than existing methods.

peptides peptide sax-spe ip-rp-hplc cross-run
Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation.

PMID 18806875 · PMC2532751 · PloS one · 2008 · 8 claims · 8 setups

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PCMT overexpression protects porcine aortic endothelial cells (PAEC) from H2O2-induced apoptosis, raising the threshold H2O2 concentration required to trigger cell death.

porcine paec umbilical huvec methyltransferase sds-page fragmentation
The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.

PMID 18726985 · PMC2826114 · The Prostate · 2008 · 7 claims · 8 setups

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Quercetin treatment of prostate cancer cells decreases cell proliferation and viability in a dose-dependent manner

pc-3 excised prostate viability difference nano

Experiments

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.

miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes.

Reduced transcription of TCOF1 in adult cells of Treacher Collins syndrome patients.

Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay.

The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells.

Improved tagging strategy for protein identification in mammalian cells.

Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.

Association between telomere length and V(H) gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications.

CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas.

Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach.

The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.

Interaction of vitamin D receptor with HLA DRB1 0301 in type 1 diabetes patients from North India.

A homozygous CARD9 mutation in a family with susceptibility to fungal infections.

Identification of transcription start sites and preferential expression of select CB2 transcripts in mouse and human B lymphocytes.

miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1.

Weighted gene co-expression network analysis reveals that CXCL10, IRF7, MX1, RSAD2, and STAT1 are related to the chronic stage of spinal cord injury.

CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

Statistical learning of peptide retention behavior in chromatographic separations: a new kernel-based approach for computational proteomics.

Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation.

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.