Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Critical role for a high-plasticity cell state in lung cancer.

  PMID 41565826 · PMC12960256 · Nature · 2026 · 8 claims · 8 setups

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  The HPCS is a transcriptionally distinct cancer cell state that functions as a hub for reciprocal transitions between other cancer cell states

  autochthonous kpfrt gfp+ sorted single-cell flow immunofluorescence

• Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

  PMID 41639447 · PMC12935554 · Nature · 2026 · 8 claims · 8 setups

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  Lung adenocarcinoma (LUAD) induces increased innervation and functional/transcriptional engagement of vagal sensory neurons (VSNs)

  kras-g12d tumour-bearing vagal npy2r-ires-cre whole-mount aav neurite

• Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.

  PMID 41735308 · PMC13043769 · Nature communications · 2026 · 8 claims · 8 setups

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  OSGEP is the catalytic subunit of the KEOPS complex responsible for t6A modification at position 37 of cytoplasmic tRNAs, and its loss causes the highest protein aggregation among 45 screened tRNA-modifying enzymes in melanoma cells

  mm117 b16f10 b16f10-derived c57bl esirna shrna rna-seq

• Atlas-guided discovery of transcription factors for T cell programming.

  PMID 41639465 · PMC13017511 · Nature · 2026 · 8 claims · 8 setups

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  A multi-omics atlas (Taiji pipeline) integrating RNA-seq and ATAC-seq across nine CD8+ T cell states can predict TF activity and identify state-selective versus multi-state TFs

  cd8+ lcmv p14 c57bl rna-seq pearson crispr