Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Adhesion-Related Macrophages Regulate Metabolic Homeostasis Through CAV-1 Dependency.

  PMID 41817010 · PMC13159151 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  Adhesion-related macrophages (ARMs) are a distinct macrophage subpopulation that adheres directly to adipocytes and can be isolated using a novel vortex/bead-based method

  ewat facs-sorted arms sort-purified flow bulk atac-seq

• Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.

  PMID 41933175 · PMC13052164 · Nature metabolism · 2026 · 8 claims · 8 setups

  Has reproduction · 48

  Irisin modulates adipose tissue inflammation by increasing IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues, thereby improving obesity and glucose intolerance.

  4-week-old hfd-fed bat iwat aav8-mediated body intraperitoneal

• Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow.

  PMID 42043300 · PMC13120821 · eLife · 2026 · 8 claims · 8 setups

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  Adult bone marrow-resident Cdh5/VE-Cadherin+ endothelial cells produce hematopoietic cell progeny both in vitro and in vivo.

  bone lin sorted lethally flow confocal sorted-cell

• Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

  PMID 41547846 · PMC12910057 · NPJ breast cancer · 2026 · 8 claims · 8 setups

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  Deletion of host Il1α causes rejection/regression of transplanted breast tumors

  h605 pymt tumor-infiltrating two-week orthotopic flow single-cell

• Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance.

  PMID 41559445 · PMC12945688 · Nature metabolism · 2026 · 8 claims · 8 setups

  Has reproduction · 85

  Distinct sympathetic neuron subpopulations in the stellate ganglion (SG) innervating iBAT parenchyma versus its vasculature mediate separable functions of the depot.

  th-cre awake ibat plasma retrograde chemogenetic indirect

• De novo identification of CD4(+) T cell epitopes.

  PMID 38658646 · PMC11093748 · Nature methods · 2024 · 7 claims · 8 setups

  Has reproduction · 83

  SABR-IIs (chimeric receptors linking a covalently attached peptide-MHC-II to CD28-CD3ζ signaling domains) present epitopes to CD4+ T cells and induce a readable NFAT-GFP/CD69 signal upon cognate TCR recognition

  nfat-gfp hla-dq8 5kc daudi nfat-gfp co-incubation species

• MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.

  PMID 41759510 · PMC7618887 · Immunity · 2026 · 8 claims · 8 setups

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  MafB is required for full differentiation of bone-marrow-derived macrophages (BMDMs) in vitro and for development of most RTMs in vivo

  bmdms peritoneal rtms irradiated bulk hashtag-barcoded intracellular

• Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

  PMID 41800251 · PMC12965062 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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  TMZ enhances mitochondrial membrane potential and suppresses fatty acid oxidation (FAO) in human T cells

  peripheral endoc-βh5 nod pancreatic mitochondrial extracellular glucose-stimulated

• Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization.

  PMID 40905825 · PMC12793834 · Cancer discovery · 2026 · 8 claims · 8 setups

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  AHR ligands (cigarette smoke extract and TCDD) promote PDAC tumor growth in a syngeneic orthotopic mouse model

  pdac naïve il22 orthotopic naïve western

• Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.

  PMID 41704758 · PMC12907124 · iScience · 2026 · 8 claims · 8 setups

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  Aurkb is upregulated in a subset of fetal/neonatal microglia and in microglia following CPZ-induced demyelination and in MS patient microglia

  microglia brain neonatal corpus scrna-seq western immunofluorescence

• Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy.

  PMID 41494534 · PMC12866099 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  VPNS@P selectively accumulates in immune cells within atherosclerotic plaques (predominantly macrophages and monocytes, partly T and B cells) with minimal off-target uptake by non-immune vascular cells

  vpns@p cell-free raw264.7 bone-marrow-derived tem ros-scavenging cck-8