Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 26

System / cell line: plasma ✕ Assay: fractionation ✕ Clear

Logical Analysis of Data (LAD) model for the early diagnosis of acute ischemic stroke.

PMID 18616825 · PMC2492849 · BMC medical informatics and decision making · 2008 · 7 claims · 5 setups

Full-text index only

An LAD classification model built from a support-set of 3 peptide peaks can distinguish stroke patients from controls with 75% accuracy on an independent validation set

plasma discretized seldi-tof serum logical
PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.

PMID 30904610 · PMC6624118 · Biochimica et biophysica acta. Molecular basis of disease · 2019 · 8 claims · 8 setups

Has reproduction

PID1 serves as an insulin-regulated retention adaptor protein controlling co-translocation of LRP1 and GLUT4 to the adipocyte plasma membrane

brown bat muscle qrt-pcr western insulin
Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer.

PMID 17303479 · PMC7105233 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2007 · 5 claims · 5 setups

Full-text index only

Pre-fractionation of plasma with immuno-affinity depletion and anion-exchange chromatography prior to 2D-DIGE substantially increases the number of detectable protein spots compared with unfractionated plasma.

plasma excised fractionated 2d-dige multi-dimensional lc-ms
A proteomic approach for plasma biomarker discovery with iTRAQ labelling and OFFGEL fractionation.

PMID 19888438 · PMC2771280 · Journal of biomedicine & biotechnology · 2010 · 6 claims · 6 setups

Full-text index only

iTRAQ labelling combined with OFFGEL fractionation improves proteome coverage of human plasma compared to iTRAQ alone or no iTRAQ

pooled plasma prefractionated immunodepleted itraq 1-dimensional fluorescence-based
A mouse to human search for plasma proteome changes associated with pancreatic tumor development.

PMID 18547137 · PMC2504036 · PLoS medicine · 2008 · 7 claims · 8 setups

Full-text index only

GEM models combined with in-depth proteomic analysis provide a useful strategy to identify candidate cancer markers applicable to human disease with potential for early detection

plasma immunodepleted pancreatic shotgun two-dimensional immunodepletion
Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome.

PMID 19722698 · PMC2783519 · Journal of proteome research · 2009 · 7 claims · 6 setups

Full-text index only

Tandem IgY7-SuperMix separation nearly doubles overall proteome coverage compared to IgY7 flow-through alone (523 vs 263 confidently identified proteins)

plasma identified lc-ms sds-page spike-in
High-throughput genomic technology in research and clinical management of breast cancer. Plasma-based proteomics in early detection and therapy.

PMID 17184556 · PMC1797031 · Breast cancer research : BCR · 2006 · 8 claims · 8 setups

Full-text index only

Plasma is well suited to proteomic biomarker discovery because it is easily obtained, routinely used diagnostically, and has a rich proteome.

plasma serum maldi-tof seldi-tof tandem
A mouse plasma peptide atlas as a resource for disease proteomics.

PMID 18522751 · PMC2481425 · Genome biology · 2008 · 8 claims · 6 setups

Full-text index only

A publicly available, high-quality mouse plasma peptide/protein repository (mouse PeptideAtlas) was built from 568 LC-MS/MS runs on four reference plasma pools.

plasma peptides fully tissues lc-ms anion database
Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery.

PMID 19936259 · PMC2775948 · PloS one · 2009 · 8 claims · 8 setups

Full-text index only

Integrated proteomic analysis of a cancer mouse model and human cancer cell populations provides an effective approach to identify potential circulating protein biomarkers.

k-ras ovarian lists tumor quantitative pathway immunoblot
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

PMID 28346411 · PMC5699924 · Nature medicine · 2017 · 8 claims · 8 setups

Has reproduction · 78

12,13-diHOME is a cold-induced lipokine that stimulates BAT activity

plasma bat serum mice lc-ms correlation 18f-fdg
Sample preparation for serum/plasma profiling and biomarker identification by mass spectrometry.

PMID 17166507 · PMC7094463 · Journal of chromatography. A · 2007 · 8 claims · 8 setups

Full-text index only

Standardizing sample preparation procedures for serum/plasma profiling is critical for obtaining reliable biomarkers, since slight procedural changes can produce very different protein profiles.

serum aqueous maldi-tof seldi-tof peak
Proteomics studies reveal important information on small molecule therapeutics: a case study on plasma proteins.

PMID 18973825 · PMC7185545 · Drug discovery today · 2008 · 8 claims · 8 setups

Full-text index only

Abundant plasma proteins (albumin, IgG, transferrin) act as 'molecular sponges' that bind and transport low molecular weight proteins/peptides and drugs, extending their half-life by preventing rapid renal clearance.

blood schizophrenia sjl serum proteomic differential comparative
Apolipoprotein A-IV, a putative satiety/antiatherogenic factor, rises after gastric bypass.

PMID 18948973 · PMC2627784 · Obesity (Silver Spring, Md.) · 2009 · 6 claims · 7 setups

Full-text index only

Apolipoprotein A-IV (apo A-IV) is significantly increased in fasting plasma after RYGBP compared to pre-operative levels

fasting plasma itraq-labeled subjects itraq immunoblot sds-page
Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ).

PMID 19902006 · PMC2774473 · Journal of biomedicine & biotechnology · 2010 · 8 claims · 5 setups

Full-text index only

iTRAQ labelling combined with 4800 MALDI TOF/TOF can detect quantitative differences in the maternal plasma proteome between DS and euploid pregnancies

maternal tryptic scx-fractionated identified itraq immunodepletion strong
Use of proteomics for validation of the isolation process of clotting factor IX from human plasma.

PMID 19819359 · PMC2818390 · Journal of proteomics · 2010 · 8 claims · 8 setups

Full-text index only

Proteomic techniques (LC-MS/MS, iTRAQ, immunochemical/biochemical methods) can monitor and validate each production step of pd F IX isolation

plasma in-process chromatographic one-stage competitive elisa
Perspectives of targeted mass spectrometry for protein biomarker verification.

PMID 19818677 · PMC2795387 · Current opinion in chemical biology · 2009 · 8 claims · 8 setups

Full-text index only

SRM/MRM mass spectrometry can quantify targeted proteotypic peptides as surrogates for candidate biomarker proteins in complex plasma samples

proteins standard plasma sera srm multiplexed immunoaffinity-srm
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

PMID 25754609 · PMC4366535 · Nature communications · 2015 · 7 claims · 8 setups

Has reproduction

β3-AR agonist-mediated BAT activation reduces plasma triglycerides and cholesterol and protects against atherosclerosis development in APOE*3-Leiden.CETP mice.

e3l.cetp interscapular liver aortic indirect histology plasma
High-accuracy proteome maps of human body fluids.

PMID 17140426 · PMC1794581 · Genome biology · 2006 · 8 claims · 5 setups

Full-text index only

Large-scale, high-accuracy MS analyses of tear fluid, urine, and seminal plasma provide high-quality datasets useful for biomarker discovery

tear-duct urine seminal blood lc-ms large-scale decoy
iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype.

PMID 19674965 · PMC2773724 · Molecular & cellular proteomics : MCP · 2009 · 6 claims · 5 setups

Full-text index only

Serial transplantation of human GBM xenografts in nude rats converts an initially highly infiltrative, non-angiogenic phenotype into a highly angiogenic phenotype over 4-6 generations.

membrane-enriched xenograft homogenate quantified itraq western bradford
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.

PMID 16700915 · PMC1482678 · Cardiovascular diabetology · 2006 · 8 claims · 6 setups

Full-text index only

A haplotype of three AdipoR2 variants (+795G/A, +870C/A, +963C/T) in perfect linkage disequilibrium is associated with higher plasma adiponectin levels and lower fasting triglyceride, VLDL-triglyceride, and VLDL-cholesterol levels

peripheral plasma subjects adipor1 sequencing plasma preparative

Experiments

Logical Analysis of Data (LAD) model for the early diagnosis of acute ischemic stroke.

PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.

Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer.

A proteomic approach for plasma biomarker discovery with iTRAQ labelling and OFFGEL fractionation.

A mouse to human search for plasma proteome changes associated with pancreatic tumor development.

Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome.

High-throughput genomic technology in research and clinical management of breast cancer. Plasma-based proteomics in early detection and therapy.

A mouse plasma peptide atlas as a resource for disease proteomics.

Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery.

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Sample preparation for serum/plasma profiling and biomarker identification by mass spectrometry.

Proteomics studies reveal important information on small molecule therapeutics: a case study on plasma proteins.

Apolipoprotein A-IV, a putative satiety/antiatherogenic factor, rises after gastric bypass.

Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ).

Use of proteomics for validation of the isolation process of clotting factor IX from human plasma.

Perspectives of targeted mass spectrometry for protein biomarker verification.

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

High-accuracy proteome maps of human body fluids.

iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype.

Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.