Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR.

  PMID 41771837 · PMC12953643 · Signal transduction and targeted therapy · 2026 · 8 claims · 8 setups

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  KLF15 transcriptional activity shows the most significant change among TFs in pathological cardiomyocytes during progressive hypertrophic remodeling, reflecting less effective repression of disease-associated genes.

  ventricular heart cardiomyocytes cardiomyocyte single-cell rt-qpcr bulk

• Alternative polyadenylation links RNA processing to iron metabolism in human erythropoiesis.

  PMID 41805127 · PMC12972907 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  CPSF6 facilitates erythropoiesis; its depletion impairs heme synthesis and causes intracellular iron deficiency

  cd34+ cd34+-derived bone erythroid scrna-seq bulk long-read

• Spatial perturb-seq: single-cell functional genomics within intact tissue architecture.

  PMID 41723140 · PMC13035813 · Nature communications · 2026 · 8 claims · 8 setups

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  Spatial Perturb-Seq simultaneously measures whole transcriptome (cell type), CRISPR barcodes (perturbation), spatial coordinates, and cell-cell interactions through a single Stereo-seq and/or Xenium run.

  hippocampus bone brain aav-transduced scrna-seq snrna-seq spatial

• Live-cell Pick-Seq (LiP-Seq): Interrogating ultra-rare mantle cell lymphoma persistent cells after CART19 therapy.

  PMID 41855504 · PMC13234471 · Blood advances · 2026 · 8 claims · 7 setups

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  LiP-Seq is a novel platform combining multiplexed live-cell imaging and needle-based single-cell retrieval that enables transcriptomic profiling of ultrarare (down to 10^-6 frequency), viable persistent lymphoma cells

  mcl longitudinal scrna-seq pbmc live-cell sort-seq scrna-seq

• The macrophage entry mechanism of SARS-CoV-2 mediated by surface CD98/TMPRSS11E complex is associated with the cellular tropism toward proinflammatory M1 and pathogenesis.

  PMID 41877147 · PMC13137717 · Respiratory research · 2026 · 8 claims · 8 setups

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  CD98 (CD98hc/SLC3A2) is a novel receptor for the SARS-CoV-2 Spike protein

  thp-1-derived 293t structures thp-1 co-ip co-immunoprecipitation molecular