Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Full-text index only
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.
PMID 18617507 · PMC2577208 · Molecular & cellular proteomics : MCP · 2008 · 8 claims · 8 setups
Nuclear Ran GTPase was identified by mass spectrometry as a novel interacting partner of VRK1 and VRK2B
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Full-text index only
Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments.
PMID 18765474 · PMC2577354 · Nucleic acids research · 2008 · 6 claims · 6 setups
Extensive sonication reduces crosslinked chromatin to an average fragment size of ~200 bp (range 75–300 bp) and fragmentation is largely random with respect to genomic region and nucleosome position.
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Has reproduction · 80
The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.
PMID 29754816 · PMC6371919 · Cell · 2018 · 8 claims · 7 setups
Co-entrapment of sister DNAs inside cohesin rings (CDs) correlates perfectly with sister chromatid cohesion across multiple cell-cycle stages and mutants
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Has reproduction · 64
Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex.
PMID 31201089 · PMC6675936 · Molecular cell · 2019 · 8 claims · 8 setups
Smc1 and Smc3 ATPase heads adopt two distinct interaction states in vivo: an ATP-dependent engaged (E) state and a signature-motif juxtaposed (J) state, and these are mutually exclusive.