Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB.

  PMID 41505470 · PMC12810902 · PLoS genetics · 2026 · 8 claims · 6 setups

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  1,25D treatment induces widespread transcriptional and chromatin accessibility changes in colonic organoids

  colonic bulk atac-seq gene

• Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.

  PMID 41673768 · PMC12998334 · Journal of experimental & clinical cancer research : CR · 2026 · 6 claims · 8 setups

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  Organoids derived from malignant effusions of PDAC patients reproducibly generate peritoneal metastases after orthotopic implantation into the pancreas of immunodeficient mice

  pdac organoids frozen pdox orthotopic single-nucleus single-cell

• Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases.

  PMID 41484106 · PMC12881549 · Nature communications · 2026 · 8 claims · 8 setups

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  Loss/inhibition of IKKα unexpectedly promotes, rather than suppresses, CRC liver metastasis in patient-derived organoid (PDO) xenograft models.

  pdo5 pdo5-derived crc dld1 intrasplenic immunohistochemistry kaplan-meier

• Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation.

  PMID 41688638 · PMC12987725 · Nature genetics · 2026 · 8 claims · 8 setups

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  Variants in the OR51E1–OR51E2 locus, encoding microbiome-derived fatty acid chemosensors expressed in enteroendocrine cells, are associated with gut microbial richness

  adults subset intestinal enteroendocrine genome-wide sanger single-cell

• Loss of fungal sensing exacerbates liver injury in a murine model of MASLD.

  PMID 41805789 · PMC13135407 · JCI insight · 2026 · 8 claims · 8 setups

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  Patients with advanced liver fibrosis exhibit distinct gut mycobiota profiles, with the genus Penicillium notably reduced in severe fibrosis

  fecal wild-type gut card9 16s random diet-induced