Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 9

System / cell line: plasmid ✕ Assay: genetic ✕ Clear

Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli.

PMID 17012280 · PMC1636463 · Nucleic acids research · 2006 · 7 claims · 5 setups

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DSBs induced at the TRS/vector junction (EcoRV site) generate numerous mutagenic events in flanking sequences, whereas DSBs within the repeat tract (EcoRI site) produce no such mutants

coli plasmids plasmid white plasmid sequencing non-b
High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform.

PMID 17702760 · PMC2018616 · Nucleic acids research · 2007 · 7 claims · 4 setups

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An integrated strategy combining en masse pentapeptide insertion mutagenesis, yeast two-hybrid screening, and parallel genetic footprinting can map protein-protein interfaces at amino acid precision and is generally applicable to any interacting protein pair.

saccharomyces plasmid pooled individual yeast pcr-based restriction
Genomic diversity and evolution of Mycobacterium ulcerans revealed by next-generation sequencing.

PMID 19806175 · PMC2736377 · PLoS pathogens · 2009 · 8 claims · 6 setups

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Genome sequencing of three M. ulcerans strains (NM20/02, NM31/04, Jp8756) identified thousands of SNPs relative to reference strain Agy99

ulcerans collection snp whole-genome comparative read
Genetic diversity of clinical isolates of Bacillus cereus using multilocus sequence typing.

PMID 18990211 · PMC2585095 · BMC microbiology · 2008 · 8 claims · 7 setups

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The 55 clinical B. cereus isolates were phylogenetically diverse, comprising 38 sequence types (STs) distributed across two of three previously described clades.

clinical concatenated cereus isolates multilocus phylogenetic pcr
Analysis of chimpanzee history based on genome sequence alignments.

PMID 18421364 · PMC2278377 · PLoS genetics · 2008 · 8 claims · 6 setups

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Bonobos and common chimpanzees separated approximately 1.29 million years ago

bonobo bonobos chimpanzee simulated shotgun sequenom principal
Viral and host determinants of RNA virus vector replication and expression.

PMID 15734041 · PMC7115378 · Vaccine · 2005 · 7 claims · 4 setups

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BMV RNA replication occurs in a virus-induced, membrane-bounded compartment rather than in the open cytoplasm.

bmv saccharomyces wild-type immunogold genome-wide northern
Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa.

PMID 16652333 · PMC1828612 · Human mutation · 2006 · 7 claims · 6 setups

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FBLN5 missense mutations are associated with ARMD in a European (UK/Dutch) cohort, confirming prior US findings

armd dutch fibulin pef6-ssflag mutation computational site-directed
A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen Streptococcus suis.

PMID 41880495 · PMC13015895 · Science advances · 2026 · 8 claims · 8 setups

Has reproduction · 77

Pathogenic S. suis lineages express two structural RPS variants that differ by presence/absence of glucose but share a conserved glycan core

publicly suis rps δsrpp comparative plant glycosyl
Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations.

PMID 33304461 · PMC7710658 · Computational and structural biotechnology journal · 2020 · 7 claims · 6 setups

Has reproduction

Expression stability in CHO cell lines is controlled at three levels: choice of integration site, integrity/concatemerization pattern of the transgene, and stress-related cellular processes.

horizon six cho-k1 cho genome rna-seq targeted

Experiments

Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli.

High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform.

Genomic diversity and evolution of Mycobacterium ulcerans revealed by next-generation sequencing.

Genetic diversity of clinical isolates of Bacillus cereus using multilocus sequence typing.

Analysis of chimpanzee history based on genome sequence alignments.

Viral and host determinants of RNA virus vector replication and expression.

Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa.

A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen Streptococcus suis.

Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations.