Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia.

  PMID 17117617 · PMC3181819 · Dialogues in clinical neuroscience · 2006 · 8 claims · 4 setups

  Full-text index only

  DISC1 mRNA expression does not differ between schizophrenic and control postmortem brain tissue

  postmortem pc12 expression immunohistochemistry genetic

• The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease.

  PMID 38502590 · PMC11567244 · Aging and disease · 2024 · 7 claims · 6 setups

  Has reproduction · 57

  A distinct astrocyte subpopulation marked by low GFAP, plus AQP4 and CD63 expression, exists in normal brain but is diminished in AD samples in both human and mouse.

  prefrontal snrna-seq frontal brain single-nuclei gene cell-cell

• Prominent neuroleptic sensitivity in a case of early-onset Alzheimer disease due to presenilin-1 G206A mutation.

  PMID 18797263 · PMC4867177 · Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2008 · 8 claims · 8 setups

  Full-text index only

  A patient with the PS-1 G206A mutation developed prominent extrapyramidal signs (EPS) shortly after starting the atypical neuroleptic risperidone, which resolved completely after the drug was discontinued.

  cerebrospinal genomic brain blood elisa genetic apoe

• A Meta-Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models.

  PMID 41031900 · PMC13131251 · Journal of sleep research · 2026 · 7 claims · 6 setups

  Has reproduction · 96

  Meta-analysis of 18 SD-vs-control contrasts identified 182 genes differentially expressed in the murine cortex in response to sleep deprivation (FDR < 0.05).

  c57bl full genes meta-analysis affymetrix rna-seq random-effects

• A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex.

  PMID 34253796 · PMC8275748 · Scientific reports · 2021 · 8 claims · 8 setups

  Has reproduction · 84

  The ERV locus HML6_3p21.31c is significantly upregulated in ALS post-mortem motor cortex after multiple-testing correction

  post-mortem als bulk cell-type weighted

• Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models.

  PMID 36254682 · PMC9612871 · Disease models & mechanisms · 2022 · 8 claims · 8 setups

  Has reproduction · 100

  iPSC-microglia show a shared core transcriptional response to ATPγS and to LPS+IFN-γ, suggesting a convergent mechanism of action

  ipsc-derived products microglia post-mortem single-cell ca2+ protein-protein