Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 6

System / cell line: cardiac ✕ Assay: genome ✕ Clear

Human-zebrafish non-coding conserved elements act in vivo to regulate transcription.

PMID 16179648 · PMC1236720 · Nucleic acids research · 2005 · 8 claims · 4 setups

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Deeply conserved human-zebrafish non-coding elements are enriched for in vivo cis-acting transcriptional regulatory activity.

ncbi genes zebrafish comparative annotation gfp
Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities.

PMID 35922433 · PMC9349177 · Nature communications · 2022 · 8 claims · 7 setups

Has reproduction

Genome-wide association of six CMR-derived aortic traits in up to 32,590 UK Biobank participants identifies 102 loci (including 27 novel associations) for aortic distensibility and area.

biobank arterial aortic genome-wide multi-trait cardiac
Inference of transcriptional regulation using gene expression data from the bovine and human genomes.

PMID 17683551 · PMC1978505 · BMC genomics · 2007 · 7 claims · 8 setups

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Using human reference promoter sequences is a useful approach for studying gene expression regulation in species with limited or non-existing genomic sequence, such as cattle.

muscle-specific bovine refseq cardiac novo est blastn
Genetic architecture of natural variation of cardiac performance from flies to humans.

PMID 36383075 · PMC9668334 · eLife · 2022 · 8 claims · 7 setups

Has reproduction · 74

Natural genetic variation significantly influences cardiac performance traits (rhythmicity and contractility) across 167 DGRP lines

drosophila dgrp gene induced high-speed genome-wide epistasis
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.

PMID 18443592 · PMC2742198 · Nature genetics · 2008 · 8 claims · 8 setups

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Osteoglycin (Ogn) is a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM

heart ogn cos-1 neonatal eqtl quantitative genome-wide
Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes.

PMID 16569242 · PMC1444927 · BMC medical genetics · 2006 · 7 claims · 4 setups

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Linkage and haplotype analysis in the South African family are highly suggestive of linkage to the ARVC6 locus on chromosome 10p12-p14

south genomic family genetic direct bioinformatic

Experiments

Human-zebrafish non-coding conserved elements act in vivo to regulate transcription.

Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities.

Inference of transcriptional regulation using gene expression data from the bovine and human genomes.

Genetic architecture of natural variation of cardiac performance from flies to humans.

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.

Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes.