Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 78
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.
PMID 28346411 · PMC5699924 · Nature medicine · 2017 · 8 claims · 8 setups
12,13-diHOME is a cold-induced lipokine that stimulates BAT activity
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Has reproduction · 97
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.
PMID 27117818 · PMC4853423 · Nature communications · 2016 · 8 claims · 8 setups
Brown and beige adipocytes release exosomes, and thermogenic activation increases exosome release both in vitro and in vivo.
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Has reproduction
Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice.
PMID 32769145 · PMC7604721 · Journal of lipid research · 2020 · 6 claims · 4 setups
Glucose and lipoprotein handling by thermogenic adipose tissue does not necessarily reflect UCP1-dependent thermogenic activity
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Has reproduction
TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.
PMID 33516944 · PMC7903014 · Molecular metabolism · 2021 · 7 claims · 8 setups
BAT whitening at thermoneutrality is associated with TFEB-dependent mitochondrial degradation.
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Has reproduction · 48
Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.
PMID 41933175 · PMC13052164 · Nature metabolism · 2026 · 8 claims · 8 setups
Irisin modulates adipose tissue inflammation by increasing IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues, thereby improving obesity and glucose intolerance.