Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis.
PMID 41714361 · PMC13022353 · EMBO reports · 2026 · 8 claims · 8 setups
PHF8 is required for neural stem cell (NSC) proliferation in vitro
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Has reproduction · 90
Evolutionary repair: Changes in multiple functional modules allow meiotic cohesin to support mitosis.
PMID 32155147 · PMC7138332 · PLoS biology · 2020 · 8 claims · 7 setups
Replacing Scc1 with Rec8 in mitosis impairs sister chromosome cohesion, advances the timing of genome replication, and reduces reproductive fitness by 45%
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chromIDEAS reveals epigenetic dynamics via multi-dimensional clustering of chromatin states.
PMID 41816913 · PMC12980073 · Nucleic acids research · 2026 · 8 claims · 8 setups
chromIDEAS groups chromatin states into functionally coherent clusters by jointly analyzing epigenetic composition and genomic distribution
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Sequence and chemical specificity define the functional landscape of intrinsically disordered regions.
PMID 41688823 · PMC12904797 · Nature cell biology · 2026 · 8 claims · 8 setups
IDR function depends on two distinct but related properties: sequence specificity (motifs) and chemical specificity (distributed multivalent chemistry)
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Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication.
PMID 19014595 · PMC2615443 · Retrovirology · 2008 · 7 claims · 8 setups
IN mutants V165A, A179P and KR186,7AA in the C-terminal region of the catalytic core domain fail to induce the lethal phenotype in HP16 yeast
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Putting proteins in one place.
PMID 12790144 · PMC1316915 · Environmental health perspectives · 2003 · 8 claims · 7 setups
Rapamycin inhibits TOR, causing the silencing protein Sir3 to detach from chromatin at stress-response genes, triggering a coordinated multigene stress response that halts cancer cell proliferation
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CITED2 is a druggable epigenetic switch coupling neuronal maturation to regenerative decline.
PMID 41731079 · PMC13083982 · EMBO molecular medicine · 2026 · 8 claims · 8 setups
The transition from immature non-polarized to mature polarized DRG neurons (E12.5-E17.5) is associated with loss of gene expression signatures needed for regenerative growth competence.
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With the finished human genome in hand, what next?
PMID 12844356 · PMC193627 · Genome biology · 2003 · 8 claims · 8 setups
Gene Ontology (GO) provides a syntax/query framework for functional classification of genes, expanding beyond E. coli origins into anatomy, pathology, and phenotype data.
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Has reproduction · 68
Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression.
PMID 41963303 · PMC13181133 · Cell death & disease · 2026 · 8 claims · 8 setups
The integrated stress response (ISR) induces CRC cell plasticity, subclonal diversity, and tumor progression in stress-surviving cells
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Has reproduction · 50
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.
PMID 33420019 · PMC7794422 · Nature communications · 2021 · 8 claims · 8 setups
SNAI2 is highly expressed in FN-RMS tumors and cell lines compared to normal tissue
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MECOM Function Is Critical for AR-Driven Treatment-Resistant Prostate Cancer.
PMID 41529070 · PMC13136877 · Cancer research · 2026 · 7 claims · 8 setups
EVI1, encoded by MECOM, is an AR-recruited coactivator of noncanonical AR signaling in prostate cancer.
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SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.
PMID 41807550 · PMC13249849 · NPJ precision oncology · 2026 · 8 claims · 8 setups
MCL1 inhibition is synthetic lethal with SMARCA4/2 loss in SCCOHT and NSCLC cells
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Has reproduction · 58
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma.
PMID 31784732 · PMC6886578 · Nature genetics · 2019 · 8 claims · 8 setups
SOX8 is a previously unrecognized core regulatory TF in FP-RMS, co-localizing with other CR TFs at SEs and essential for tumor cell growth
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Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers.
PMID 41579861 · PMC12923976 · Cell reports. Medicine · 2026 · 8 claims · 8 setups
oncRNA binary presence-absence patterns constitute digital molecular barcodes that capture cancer type and subtype identity
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FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.
PMID 41621066 · PMC13050545 · Cell reports · 2026 · 8 claims · 8 setups
FOXA1 mutations in a 874-tumor cohort cluster into missense, in-frame indel, and truncation subgroups, with indels concentrated at residues M253/E255
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A statistical framework for consolidating "sibling" probe sets for Affymetrix GeneChip data.
PMID 18435860 · PMC2397416 · BMC genomics · 2008 · 7 claims · 4 setups
A two-way ANOVA model with a treatment x probe-set interaction term can automatically determine whether sibling probe sets for a gene behave similarly (non-significant interaction, consolidate) or differently (significant interaction, treat as independent)