Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication.
PMID 19014595 · PMC2615443 · Retrovirology · 2008 · 7 claims · 8 setups
IN mutants V165A, A179P and KR186,7AA in the C-terminal region of the catalytic core domain fail to induce the lethal phenotype in HP16 yeast
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Has reproduction · 68
Differential bone morphology and hypoxia activity in skeletal metastases of ER(+) and ER(-) breast cancer.
PMID 39572705 · PMC11582807 · Communications biology · 2024 · 8 claims · 8 setups
ER− MDA-MB-231 breast cancer forms more osteolytic bone metastases than ER+ MCF-7 breast cancer
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Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth.
PMID 18505588 · PMC2430713 · BMC genomics · 2008 · 8 claims · 8 setups
Comparative genomics of B. longum DJO10A (minimally cultured) and NCC2705 (culture collection strain) reveals 17 unique DNA regions in DJO10A and 6 in NCC2705 despite otherwise high genome collinearity and identity
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Pathway analysis for intracellular Porphyromonas gingivalis using a strain ATCC 33277 specific database.
PMID 19723305 · PMC2753363 · BMC microbiology · 2009 · 8 claims · 5 setups
Using the ATCC 33277-specific genome annotation improves proteome coverage (more proteins identified and more abundance ratios calculated) compared to the W83 annotation
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Gene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane yield in sheep.
PMID 28789673 · PMC5549432 · BMC research notes · 2017 · 7 claims · 7 setups
Gene and transcript abundances of bacterial type III secretion system (T3SS) genes are positively correlated with methane yield in sheep
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Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection.
PMID 17217429 · PMC2064037 · Cellular microbiology · 2007 · 6 claims · 3 setups
Proteomic analysis (2-DGE coupled with ADI-MS/MS) identified 250 unique exoproteins produced by MW2 and LAC culture supernatants during growth in vitro.
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Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol.
PMID 18847467 · PMC2577666 · BMC genomics · 2008 · 6 claims · 2 setups
OPP exposure upregulates transcription of ribosomal, virulence, and membrane transport protein genes after both 20 and 60 minutes of treatment.
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Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109.
PMID 20035377 · PMC2929293 · Breast cancer research and treatment · 2010 · 8 claims · 8 setups
Serine protease inhibitors (aprotinin, SBTI) cause morphological reversion of malignant T4-2 breast cancer cells in 3D culture, restoring acinar structure and basal polarity
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Has reproduction · 50
Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology.
PMID 39941893 · PMC11817449 · Cancers · 2025 · 8 claims · 7 setups
A standardized, reproducible protocol can establish meningioma organoids (MEN-Os) from patient-resected tumor tissue without mechanical/enzymatic dissociation, using serum-free medium lacking growth factors or exogenous ECM.
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mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft.
PMID 18980691 · PMC2612029 · BMC genomics · 2008 · 8 claims · 8 setups
mtDNA depletion confers specific, shared gene expression profiles in A549 cells grown in culture and as xenografts
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Has reproduction
Benefit from decline: the primary transcriptome of Alteromonas macleodii str. Te101 during Trichodesmium demise.
PMID 29335641 · PMC5864184 · The ISME journal · 2018 · 8 claims · 7 setups
Increasing salinity to ≥43 ppt inhibits Trichodesmium growth while stimulating growth of the associated Alteromonas
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Assisted large fragment insertion by Red/ET-recombination (ALFIRE)--an alternative and enhanced method for large fragment recombineering.
PMID 17517785 · PMC1904275 · Nucleic acids research · 2007 · 6 claims · 7 setups
ALFIRE allows insertion of any fragment into small or large episomes without requiring an antibiotic selection gene in the final construct
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Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans.
PMID 18950481 · PMC2579918 · BMC microbiology · 2008 · 8 claims · 8 setups
Strain SC5314 is invasive and virulent whereas strain ATCC10231 is non-invasive and strongly attenuated in virulence
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Mathematical models in mammalian cell biology.
PMID 18638360 · PMC2530880 · Genome biology · 2008 · 8 claims · 8 setups
A point mutation in the circadian Per2 gene causes familial advanced sleep phase syndrome (FASPS) via a phosphorylation defect that alters PER2 stability and subcellular localization.
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Has reproduction · 84
Shifts from cooperative to individual-based predation defense determine microbial predator-prey dynamics.
PMID 36854789 · PMC10119117 · The ISME journal · 2023 · 8 claims · 4 setups
Across all 16 replicate co-cultures of P. putida and P. lacustris, bacteria show a consistent succession of defense strategies over five weeks (~35 predator generations).
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Has reproduction · 54
Oxidative stress protection and growth promotion activity of Pseudomonas mercuritolerans sp. nov., in forage plants under mercury abiotic stress conditions.
PMID 36560952 · PMC9763275 · Frontiers in microbiology · 2022 · 8 claims · 8 setups
Inoculation with SAICEUPSM^T significantly reduces the oxidative stress enzymatic response (CAT, APX, SOD, GR) in Lupinus albus grown under mercury stress
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Science star over Asia.
PMID 16149850 · PMC1201306 · PLoS biology · 2005 · 8 claims · 7 setups
Ariff Bongso and associates at Singapore's National University Hospital were the first to derive human embryonic stem cells, from a five-day-old discarded human embryo in 1994, and showed the cells were pluripotent with therapeutic transplant potential.
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Has reproduction · 75
A step forward for Shiga toxin-producing Escherichia coli identification and characterization in raw milk using long-read metagenomics.
PMID 36748417 · PMC9836091 · Microbial genomics · 2022 · 8 claims · 6 setups
Long-read metagenomics enables isolation-independent identification and characterization of eae-positive STEC directly from raw milk.
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Has reproduction · 88
Chromosome-Scale Assembly of the Complete Genome Sequence of Porcisia hertigi, Isolate C119, Strain LV43.
PMID 34647802 · PMC8515887 · Microbiology resource announcements · 2021 · 6 claims · 8 setups
The complete, chromosome-scale genome sequence of Porcisia hertigi (isolate C119, strain LV43) was assembled using combined short- and long-read sequencing technologies.
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Has reproduction · 78
Chromosome-Scale Assembly of the Complete Genome Sequence of Leishmania (Mundinia) orientalis, Isolate LSCM4, Strain LV768.
PMID 34498920 · PMC8428255 · Microbiology resource announcements · 2021 · 6 claims · 8 setups
The complete genome sequence of Leishmania (Mundinia) orientalis, isolate LSCM4, strain LV768, was determined using combined short-read and long-read sequencing.