Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 218

Assay: gsea ✕ Clear

CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.

PMID 41746743 · PMC13078883 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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CD38 is markedly more highly expressed on cord blood (CB) naive CD4+ T cells than adult blood (AB) naive CD4+ T cells, with an age-dependent gradient from fetal to pediatric life.

pbmcs sorted scrna-seq naive flow bulk compass
Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

PMID 41810957 · PMC13059739 · mBio · 2026 · 8 claims · 8 setups

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IFN-γ signaling in T cells contributes to the development of malaria-associated lung pathology

lungs pbnk65-infected cell-specific lung flow time-series qrt-pcr
Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.

PMID 41826553 · PMC13076647 · EMBO reports · 2026 · 8 claims · 8 setups

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Generated a novel Paneth-cell-specific SIRT1 knockout mouse model (SIRT1 PKO, Sirt1 f/f;Defa6-Cre+)

small immune facs-sorted ileum single-cell facs qpcr
l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.

PMID 41842973 · PMC13132370 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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L2HGDH deficiency causes L-2HG (not D-2HG) accumulation in patient plasma, fibroblasts, iPSCs, and NPCs

plasma patient-derived unedited day-14 metabolomics crispr proliferation
CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia.

PMID 41844049 · PMC13010944 · Neoplasia (New York, N.Y.) · 2026 · 8 claims · 8 setups

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CEBPD is identified as a novel tumor suppressor gene in AML

paired aml tcga oci-aml5 bulk bart kaplan-meier
Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.

PMID 41845440 · PMC13107627 · Cell communication and signaling : CCS · 2026 · 8 claims · 8 setups

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A bioinformatic pipeline combining RNA-seq, circRNA calling, ECDF analysis, PPI, and survival analysis identifies a circRNA-miRNA-mRNA ceRNA network in HBV-integrated HCC cells

hep3b qpcr dysregulated target bulk circrna rt-qpcr
Single-cell transcriptomics reveals heterogeneous neutrophil populations and diagnostic biomarkers in atherosclerosis.

PMID 41847341 · PMC12989409 · Frontiers in physiology · 2026 · 8 claims · 8 setups

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Integration of scRNA-seq data from six human carotid samples identified 16 distinct cell subtypes after batch effect correction with Harmony

carotid neutrophil bulk c57bl scrna-seq hdwgcna lasso
Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

PMID 41850280 · PMC13103949 · Cell reports · 2026 · 8 claims · 8 setups

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Chemotherapy-resistant KT-47R tumors show blastemal predominance and reduced stromal content compared to pre-treatment KT-47PT

kt-47 kt-47pt histology whole-exome cut&tag
Disruption of metabolic licensing by JAK inhibitors constrains CD8 T cell activation and effector function.

PMID 41876467 · PMC13039990 · Cell death & disease · 2026 · 8 claims · 8 setups

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JAKis targeting JAK1, JAK1/2, or JAK1/3 markedly reduce CD8 T cell activation markers, proliferation, and effector molecule (TNF, granzyme B) production

naive memory activated sorted flow scenith cd8
KRT15 identified by scRNA-Seq and machine learning as stemness regulator and prognostic biomarker in ESCC.

PMID 41907411 · PMC13018899 · iScience · 2026 · 8 claims · 8 setups

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A malignant epithelial subpopulation (Cluster 0) with the highest CytoTRACE stemness potential and highest EMT activity exists in ESCC scRNA-seq data

escc degs eca109 kyse180 scrna-seq machine immunohistochemistry
A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma.

PMID 41916292 · PMC13130630 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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Resistant tumors undergo convergent evolution toward a shared, spatially organized immunosuppressive ecosystem despite genetic heterogeneity.

longitudinal rois tumor exome rna-seq nanostring
Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma.

PMID 41923620 · PMC13130624 · Cell reports. Medicine · 2026 · 7 claims · 8 setups

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G9a expression inversely correlates with gene signatures predictive of favorable ICI response across multiple HCC patient cohorts

tcga advanced nm53 plc bulk single-cell rt-qpcr
Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.

PMID 41931622 · PMC13048245 · Science advances · 2026 · 7 claims · 8 setups

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Brain-specific (neural crest-derived, NC-SMC) but not peripheral (LPM-SMC/PM-SMC) iPSC-derived VSMCs are selectively vulnerable to CADASIL NOTCH3 variants

ipsc-derived ivsmcs immunofluorescence wound collagen
Helicobacter pylori-linked gene CFAP73 rewires epithelial programs and shapes the gastric cancer microenvironment.

PMID 41934579 · PMC13199538 · Discover oncology · 2026 · 8 claims · 8 setups

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CFAP73 is progressively downregulated during HP infection and is the top-ranked predictor among nine HP-suppressed genes associated with favorable gastric cancer survival

gastric tcga-stad tcga t-cell–tumor jonckheere-terpstra survival random
SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues.

PMID 41974725 · PMC13249863 · Nature communications · 2026 · 8 claims · 8 setups

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SARS-CoV-2 rarely infects villous and decidual placental tissues in the first trimester despite maternal infection

villous maternal rt-qpcr fluorescence indirect
Analysis of microsatellite instability intensity in single-cell resolution with scMnT reveals tumor heterogeneity in colorectal cancer.

PMID 41978385 · PMC13076935 · Briefings in bioinformatics · 2026 · 8 claims · 8 setups

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scMnT identifies MSI cells and quantifies MSI intensity at single-cell resolution from scRNA-seq data using mononucleotide microsatellite allele length statistics

crc cancer sc035 p20 scrna-seq snv msi
A transcriptomic-based model associated with PARP inhibitor sensitivity and immunogenic signatures in ovarian cancer.

PMID 42014663 · PMC13230468 · Discover oncology · 2026 · 8 claims · 8 setups

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A 23-gene PARPi-sensor transcriptomic model stratifies ovarian cancer patients into high- and low-risk groups with significantly different overall survival, validated in TCGA and ICGC cohorts

pdx tcga prognostic tcia bulk non-negative univariate
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

PMID 42020373 · PMC13102947 · Nature communications · 2026 · 8 claims · 8 setups

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TBL/R1 are crucial regulators of β-cell identity and determinants of diabetes development and progression

pancreatic fed paraffin-embedded pancreas qpcr blood oral
Distinct tumor genomic signatures underlie canine macrophage polarization.

PMID 42030266 · PMC13108725 · PloS one · 2026 · 8 claims · 8 setups

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Canine cancer cell lines show marked heterogeneity in macrophage polarization capacity, largely independent of histologic tumor type

monocyte-derived canine dh82 rna-seq elisa 13-plex bulk
Single-Cell Sequencing Reveals γδT Cell Heterogeneity Under Distinct Microsatellite Statuses as a Potential Biomarker for Immunotherapy and Prognosis in Colorectal Cancer.

PMID 42074506 · PMC13116210 · Genes · 2026 · 7 claims · 8 setups

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γδT cells in colorectal cancer form five distinct subsets (C0_FCER1G, C1_IL7R, C2_CD81, C3_TOP2A, C4_CXCL13) with distinct marker genes and functional states

crc γδt epithelial c4_cxcl13 single-cell differential pseudotime

Experiments

CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.

Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.

l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.

CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia.

Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.

Single-cell transcriptomics reveals heterogeneous neutrophil populations and diagnostic biomarkers in atherosclerosis.

Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

Disruption of metabolic licensing by JAK inhibitors constrains CD8 T cell activation and effector function.

KRT15 identified by scRNA-Seq and machine learning as stemness regulator and prognostic biomarker in ESCC.

A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma.

Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma.

Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.

Helicobacter pylori-linked gene CFAP73 rewires epithelial programs and shapes the gastric cancer microenvironment.

SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues.

Analysis of microsatellite instability intensity in single-cell resolution with scMnT reveals tumor heterogeneity in colorectal cancer.

A transcriptomic-based model associated with PARP inhibitor sensitivity and immunogenic signatures in ovarian cancer.

TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

Distinct tumor genomic signatures underlie canine macrophage polarization.

Single-Cell Sequencing Reveals γδT Cell Heterogeneity Under Distinct Microsatellite Statuses as a Potential Biomarker for Immunotherapy and Prognosis in Colorectal Cancer.