Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 14

System / cell line: bone ✕ Assay: gsea ✕ Clear

Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.

PMID 41644568 · PMC12982522 · Nature communications · 2026 · 8 claims · 6 setups

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MM is not characterized by T cell exhaustion but by antigen-driven terminal memory differentiation, unlike solid cancers

bone cd69+ cd8+ smm single-cell cite-seq gene
Transcriptome profiling of osteoclast subsets associated with arthritis: A pathogenic role of CCR2(hi) osteoclast progenitors.

PMID 36591261 · PMC9797520 · Frontiers in immunology · 2022 · 8 claims · 6 setups

Has reproduction · 50

CCR2hi and CCR2lo periarticular bone marrow OCP subsets show a disparate transcriptome (863 differentially expressed genes)

sorted rna-seq periarticular bulk gene flow
B-lineage commitment is dependent on a reversible epigenetic switch.

PMID 41266087 · PMC12863259 · Genes & development · 2026 · 8 claims · 8 setups

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B-lymphoid commitment is mediated by a transcription factor-dose-dependent epigenetic switch that suppresses inherent T-lineage potential in early lymphoid progenitors

bone expanded pax5 ebf1 combined atac-seq chip-seq
Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma.

PMID 41364805 · PMC13012255 · Blood cancer discovery · 2026 · 7 claims · 8 setups

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IFN-γ signaling after autologous stem cell transplant (ASCT) is associated with markers of impaired CD8+ T-cell memory phenotype

cd138neg cd138pos bone cd8+ single-cell bulk whole-genome
RANKL inhibits macrophage proinflammatory Toll-like receptor 2 and 4 signaling and impairs killing of intracellular bacteria.

PMID 42177796 · PMC13198865 · ImmunoHorizons · 2026 · 8 claims · 8 setups

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Prior RANKL exposure increases intracellular Salmonella Typhimurium (STm) burden in mouse and human macrophages

bone bmdms raw-dual splenic bacterial viability sequencing
Advanced Glycation End-Products Contribute to Delayed Diabetic Corneal Epithelial Wound Healing via the TLR4 Signaling.

PMID 41718657 · PMC12927432 · Investigative ophthalmology & visual science · 2026 · 8 claims · 8 setups

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AGE accumulation is significantly increased in diabetic corneas compared to normal corneas

bmdcs bmdc corneal t1dm sequencing western quantitative
Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation.

PMID 41675062 · PMC12886522 · iScience · 2026 · 8 claims · 8 setups

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Proliferating 20 mGy-irradiated HSC exhibit oxidative stress and altered metabolism with increased mitochondrial ROS and mitochondrial Ca2+ overload compared to non-irradiated HSC

cd45.1 hsc hspc-enriched bone flow carbonylation
MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.

PMID 41759510 · PMC7618887 · Immunity · 2026 · 8 claims · 8 setups

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MafB is required for full differentiation of bone-marrow-derived macrophages (BMDMs) in vitro and for development of most RTMs in vivo

bmdms peritoneal rtms irradiated bulk hashtag-barcoded intracellular
Identification and validation of lymphangiogenesis-related genes for predicting acute myeloid leukemia prognosis: insights from bulk RNA sequencing and single-cell RNA sequencing analyses.

PMID 41772327 · PMC12979290 · Clinical and experimental medicine · 2026 · 7 claims · 8 setups

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A 6-LYMRG risk model (ANGPT1, HGF, MAPK8, PCNA, TBL1XR1, TLR4) is the optimal prognostic signature for AML

gse142698 tcga-laml tcga-laml1 gse116256 differential univariate kaplan-meier
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

PMID 41734765 · PMC7618947 · Cell stem cell · 2026 · 8 claims · 8 setups

Has reproduction · 65

comBO is a single iPSC-derived organoid differentiation that generates osteolineage, vascular, lymphoid, and myeloid compartments together

hipsc-derived combo combo-derived healthy-donor flow single-cell confocal
Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.

PMID 41680858 · PMC12910993 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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IL4I1 mRNA expression is significantly elevated in AML compared to normal controls

tcga-laml bone thp-1-derived thp-1 bulk kaplan-meier deg
Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

PMID 41547846 · PMC12910057 · NPJ breast cancer · 2026 · 8 claims · 8 setups

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Deletion of host Il1α causes rejection/regression of transplanted breast tumors

h605 pymt tumor-infiltrating two-week orthotopic flow single-cell
PURE-seq integrates FACS and PIP-seq for single-cell genomics of ultra-rare cells.

PMID 41565684 · PMC12881479 · Nature communications · 2026 · 8 claims · 8 setups

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PURE-seq integrates FACS sorting directly into PIP-seq barcoding reaction tubes, minimizing manual handling and cell loss for rare-cell single-cell sequencing.

hek293t pbmcs melanoma bone single-cell infercnv gene
Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response.

PMID 41720793 · PMC13035812 · Nature communications · 2026 · 8 claims · 8 setups

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Lifelong CR reduces white blood cell production and shifts hematopoiesis toward myeloid and thrombo-erythroid lineages while suppressing lymphoid output

peripheral sorted young aged complete flow bulk

Experiments

Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.

Transcriptome profiling of osteoclast subsets associated with arthritis: A pathogenic role of CCR2(hi) osteoclast progenitors.

B-lineage commitment is dependent on a reversible epigenetic switch.

Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma.

RANKL inhibits macrophage proinflammatory Toll-like receptor 2 and 4 signaling and impairs killing of intracellular bacteria.

Advanced Glycation End-Products Contribute to Delayed Diabetic Corneal Epithelial Wound Healing via the TLR4 Signaling.

Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation.

MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.

Identification and validation of lymphangiogenesis-related genes for predicting acute myeloid leukemia prognosis: insights from bulk RNA sequencing and single-cell RNA sequencing analyses.

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.

Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

PURE-seq integrates FACS and PIP-seq for single-cell genomics of ultra-rare cells.

Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response.