Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Endothelial-derived PANoptosis factor IL33 is a potential immunotherapy in breast cancer.

  PMID 42095097 · PMC13141053 · iScience · 2026 · 8 claims · 8 setups

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  NMF clustering of PANoptosis-related gene expression stratifies breast cancer patients into three distinct molecular clusters (C1, C2, C3)

  tcga-brca meta-cohort training breast nmf univariate gsva

• WBT-DC pipeline: a cross-cohort and cross-platform disease classification pipeline based on whole-blood transcriptomics.

  PMID 42116144 · PMC13173921 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  WBT-DC integrates rank-based GSVA feature extraction with an ensemble random forest framework using cross-validation and hyperparameter optimization to mitigate batch effects.

  blood circulating whole-blood bulk microarray single-cell

• Machine learning-driven transcriptomic and single-cell profiling of programed cell death patterns in colon cancer.

  PMID 41854308 · PMC13009810 · Science progress · 2026 · 8 claims · 8 setups

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  Disulfidptosis and anoikis are consistently identified as the most robust prognostic PCD patterns in colon cancer across six independent machine learning algorithms

  colon coad ssgsea-based machine differential

• HCCaging: a liver physiological aging-related biomarker for hepatocellular carcinoma diagnosis based on transcriptome data.

  PMID 41942446 · PMC13230847 · npj aging · 2026 · 8 claims · 8 setups

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  A 16-gene HCCaging signature was derived via GSVA from genes overlapping age-associated upregulated genes in TCGA, scRNA-seq, and ICGC datasets

  tcga-lihc hcc icgc six bulk single-cell gsva-based

• Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.

  PMID 41927532 · PMC13046724 · Bone research · 2026 · 8 claims · 8 setups

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  Spatially resolved osteoblast-traced transcriptomics (lineage tracing + SLACS) identifies TGF-β signaling as a regulator of osteoblast activation state on quiescent bone surfaces

  dmp1-creert2 gfp+ spatial mc3t3-e1 spatially cell-type gsea

• Molecular subtype of recurrent implantation failure reveals distinct endometrial etiology of female infertility.

  PMID 40660214 · PMC12257665 · Journal of translational medicine · 2025 · 8 claims · 8 setups

  Has reproduction · 68

  RIF endometrial samples segregate into two reproducible molecular subtypes: an immune-driven subtype (RIF-I) and a metabolic-driven subtype (RIF-M)

  endometrial in-house bulk rif-degs meta-analysis sequencing immune

• Tumor-specific but immunosuppressive CD39(+)CD8(+) T cells exhibit double-faceted roles in clear cell renal cell carcinoma.

  PMID 40961944 · PMC12629791 · Cell reports. Medicine · 2025 · 8 claims · 8 setups

  Has reproduction · 88

  CD39+CD8+ TILs constitute a terminally exhausted, tumor-antigen-specific subset of CD8+ T cells

  memory sorted caix-specific cd39+pd-1bright scrna-seq bulk mhc

• Single cell profiling reveals malignant states and immune landscapes in PCNSL and systemic DLBCL.

  PMID 42023148 · PMC13097095 · iScience · 2026 · 8 claims · 8 setups

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  PCNSL and sDLBCL contain five distinct malignant B-cell subtypes (B0-B4) with discrete differentiation trajectories

  pcnsl malignant bulk sdlbcl scrna-seq infercnv cytotrace2

• Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians.

  PMID 42030936 · PMC13198318 · Cell reports. Medicine · 2026 · 8 claims · 6 setups

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  LLIs exhibit a transcriptional age younger than expected for their chronological age, as measured by clocks trained on younger controls (YCs).

  peripheral european same age-related bulk gene machine

• Distinct molecular and tumor microenvironment characteristics of mucinous adenocarcinoma in colorectal cancer.

  PMID 42100746 · PMC13145884 · iScience · 2026 · 8 claims · 8 setups

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  MAC is associated with significantly worse overall survival than CAC, but only within the MSS subtype

  tcga-crc surgically crc epithelial whole-exome copy consensus

• Plasma protein biomarkers predictive of progression to active tuberculosis among close contacts of patients with tuberculosis.

  PMID 41852731 · PMC12992532 · iScience · 2026 · 8 claims · 8 setups

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  TB progressors show broad downregulation of plasma proteins related to immune regulation, cell adhesion, and nucleotide metabolism compared to non-progressors and healthy controls

  plasma daps common six-protein olink differential kegg