Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-cell transcriptomics identifies regulatory T cell heterogeneity in gestational diabetes mellitus.

  PMID 41933176 · PMC13223204 · Communications medicine · 2026 · 8 claims · 8 setups

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  Treg cluster proportions do not significantly differ between GDM and healthy control patients

  sorted pbmcs treg gdm-patient single-cell mass gene

• Impact of enteric neuronal loss on intestinal cell composition.

  PMID 42063560 · PMC13127327 · iScience · 2026 · 8 claims · 7 setups

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  ENS loss in ret mutant zebrafish alters the non-neuronal composition of the intestine, with increased immune cells and shifts in epithelial and ECM-producing populations

  intestine ens immune phox2bb single-cell scrna-seq whole-mount

• Heterogeneity and Differentiation Trajectories of Infiltrating CD8+ T Cells in Lung Adenocarcinoma.

  PMID 36358600 · PMC9658355 · Cancers · 2022 · 7 claims · 8 setups

  Has reproduction · 67

  Infiltrating CD8+ T cells in LUAD can be divided into ten transcriptionally distinct subsets: eight cytotoxic (CTL) subsets, one naive-like (NTL) subset, and one exhausted (ETL) subset.

  luad tcga cd8+ degs single-cell cibersort survival

• Decoding the Mechanisms of Hepatocellular Carcinoma Cancer Stem Cells and Identifying Potential Therapeutic Strategies Based on Single-cell Omics.

  PMID 41771574 · PMC12951371 · Cancer genomics & proteomics · 2026 · 7 claims · 8 setups

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  Malignant cells from HCC tumors resolve into six transcriptionally distinct subpopulations, including a progenitor-like CSC subset expressing EPCAM, SOX9, and SOX4

  malignant tumor csc six single-cell spatial copy

• Metabolic reprogramming of tumor-associated macrophage clusters in ovarian cancer: a single-cell transcriptomic analysis and prognostic model.

  PMID 41933362 · PMC13173987 · BioData mining · 2026 · 8 claims · 7 setups

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  Single-cell analysis of integrated ovarian cancer datasets identifies 9 distinct mononuclear phagocyte clusters (MPC1-MPC9), of which MPC3, MPC5, and MPC7 are hypermetabolic

  ovarian mpc annotated tcga-oc single-cell gene pseudotime

• Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states.

  PMID 42020604 · PMC13175895 · Nature genetics · 2026 · 8 claims · 6 setups

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  A generalizable, network-based framework was established to systematically identify combination therapies targeting complementary coexisting tumor cell states

  malignant eight patient-derived dmg single-cell pooled plate-seq

• Single-Cell Transcriptomic Landscape of Right-Sided Colon Cancer Reveals Cellular and Molecular Features of Metastatic Potential.

  PMID 41898210 · PMC13024220 · Biomedicines · 2026 · 8 claims · 6 setups

  Has reproduction · 71

  RCC_LM tumors exhibit higher genomic instability (CNV score) than RCC_noM tumors

  right-sided malignant epithelial types scrna-seq copy trajectory

• Comprehensive analysis for the role of macrophage-driven genes in abdominal aortic aneurysm.

  PMID 41815567 · PMC12973086 · Cardiovascular diagnosis and therapy · 2026 · 8 claims · 8 setups

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  SMU1 is identified as a novel macrophage-related gene associated with AAA development, serving as a potential diagnostic biomarker and therapeutic target

  aaa macrophage-related merged gwas single-cell bulk rt-qpcr

• A differential single-cell transcriptome atlas of left-sided and right-sided colorectal cancer.

  PMID 41844817 · PMC13111741 · Discover oncology · 2026 · 8 claims · 8 setups

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  MTRNR2L8 is markedly upregulated in RCRC tumor cells and is associated with poorer patient survival

  crc epithelial rcrc tcga-read scrna-seq copy gene

• Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma.

  PMID 41916296 · PMC13130669 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  Immune and stromal heterogeneity, rather than genetic variation, are primary drivers of gene expression ITH in iCCA

  multi-region icca four lihv bulk hallmark single-cell

• TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution.

  PMID 41296555 · PMC12807651 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  TE-SCALE is a comprehensive single-cell database integrating TE expression across 20 human cancer types and 12 tissue origins

  tumor quality-controlled scrna-seq metacells scrna-seq subfamily automated

• FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment.

  PMID 41904157 · PMC13195071 · Nature communications · 2026 · 7 claims · 8 setups

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  Prostate-specific Foxa1 deletion in Pten-null mice drives tumor progression by reprogramming luminal PCa cells toward a basal/squamous-like de-differentiated state

  prostate epithelial colony lymph h&e immunohistochemistry 10x

• Clustering and machine learning-based integration identify cancer associated fibroblasts genes' signature in head and neck squamous cell carcinoma.

  PMID 37065499 · PMC10098459 · Frontiers in genetics · 2023 · 8 claims · 8 setups

  Has reproduction · 63

  Clustering of 31 CAFs genes across 868 HNSCC samples identifies two distinct molecular patterns (C1, C2) with different survival outcomes

  hnscc combined gse164690 tcga-hnsc ssgsea unsupervised immune

• Cancer-wide in silico analyses using differentially expressed genes demonstrate the functions and clinical relevance of JAG, DLL, and NOTCH.

  PMID 39074091 · PMC11285958 · PloS one · 2024 · 7 claims · 8 setups

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  JAG, DLL, and NOTCH family gene/protein expression varies diversely across 15 cancer types relative to normal tissue, sometimes discordant between mRNA and protein levels.

  tumor degs cancer jag bulk proteomics gene

• Mutually exclusive teams-like patterns of gene regulation characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma.

  PMID 38230570 · PMC10795782 · Cancer biology & therapy · 2024 · 8 claims · 6 setups

  Has reproduction · 87

  NOR-specific and MES-specific gene expression patterns are largely mutually exclusive, exhibiting a teams-like behavior across multiple bulk NB transcriptomic datasets

  lines bulk single-cell housekeeping bulk pca single-sample

• Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis.

  PMID 41419303 · PMC13151493 · Gut · 2026 · 8 claims · 8 setups

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  KC-Cpa1 mice show markedly increased pancreatic remodelling, fibrosis and metaplastic/PanIN lesion formation compared with KC mice

  pancreas cre acinar scrna-seq histology bulk single-cell

• MetaScreener: a robust dual-mode framework for directional prioritization of actionable signatures through multi-dataset and multi-approach integration.

  PMID 41845481 · PMC13107662 · Journal of translational medicine · 2026 · 8 claims · 7 setups

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  MetaScreener is a dual-mode framework (DiffMetaScreener for discrete labels, CorMetaScreener for continuous variables) integrating over 4,000 analysis pipelines to compute activation/inhibition directionality indices (ADI/IDI/DI) for gene signatures

  crc independent ctrp rko differential robustness single-cell

• Endothelial-derived PANoptosis factor IL33 is a potential immunotherapy in breast cancer.

  PMID 42095097 · PMC13141053 · iScience · 2026 · 8 claims · 8 setups

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  NMF clustering of PANoptosis-related gene expression stratifies breast cancer patients into three distinct molecular clusters (C1, C2, C3)

  tcga-brca meta-cohort training breast nmf univariate gsva

• A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells.

  PMID 34316714 · PMC8271219 · NAR cancer · 2021 · 7 claims · 8 setups

  Has reproduction · 85

  EMT and tamoxifen-resistance (TamR) regulatory axes can drive one another, enabling non-genetic heterogeneity via six co-existing phenotypes (ES, ER, HS, HR, MS, MR)

  gene same randomized publicly racipe stochastic randomized

• A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma.

  PMID 41916292 · PMC13130630 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  Resistant tumors undergo convergent evolution toward a shared, spatially organized immunosuppressive ecosystem despite genetic heterogeneity.

  longitudinal rois tumor exome rna-seq nanostring