Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Cytoplasmic LIM domain only 2 enhances tumor endothelial cell migration through integrin β1-mediated focal adhesion signaling.

  PMID 41639897 · PMC12983546 · Acta neuropathologica communications · 2026 · 8 claims · 8 setups

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  LMO2 is highly expressed in tumor-associated vasculature/endothelial cells compared with normal brain vasculature

  glioblastoma orthotopic huvecs huvec-lmo2 single-cell transcriptomic immunofluorescence

• Microglia maintain structural integrity during fetal brain morphogenesis.

  PMID 38309258 · PMC10869139 · Cell · 2024 · 8 claims · 8 setups

  Has reproduction · 68

  Embryonic ATM-like microglia accumulate at two fetal cortical boundaries, the cortico-striato-amygdalar boundary (CSA) and cortico-septal boundary (CSB), resembling post-natal axon-tract-associated microglia (ATM)

  embryonic cx3cr1 fetal embryos single-cell immunolabeling phrodo

• Identification of Foxm1 as a critical regulator for metabolic dysfunction-associated steatotic liver disease by epigenomic and transcriptional profiling.

  PMID 42088639 · PMC13137179 · Cell insight · 2026 · 8 claims · 8 setups

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  Enhancer and polycomb chromatin regions progressively increase in genomic coverage during MASLD progression

  liver aml12 chip-seq bulk histological

• RNA Editing Alterations Define Disease Manifestations in the Progression of Experimental Autoimmune Encephalomyelitis (EAE).

  PMID 36429012 · PMC9688714 · Cells · 2022 · 7 claims · 7 setups

  Has reproduction · 37

  RNA-editing events mediated by APOBEC and ADAR deaminases are significantly reduced throughout the course of EAE disease progression

  brain rna-edited brain-isolated naïve rna-seq pathway pcr

• Estrogen Production in Pancreatic Cancer Shapes a Tumor-Suppressive Stromal Microenvironment.

  PMID 41258799 · PMC12862343 · Cancer research · 2026 · 8 claims · 6 setups

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  Serum levels of stromal biomarkers associated with favorable outcomes were significantly higher in female patients with PDAC than in male patients

  pdac pdx magnetic bioinformatic single-nucleus

• A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients.

  PMID 36694043 · PMC9873918 · Communications biology · 2023 · 8 claims · 8 setups

  Has reproduction · 83

  Disease-specific temporal (dynamic) gene expression and splicing signatures, distinct from fixed timepoint differential expression, can be derived from DSS and adoptive transfer colitis models to capture acute-chronic disease dynamics

  colon blood distal ibd bulk qpcr histopathology

• A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical niches.

  PMID 41714633 · PMC13031279 · Nature communications · 2026 · 8 claims · 6 setups

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  GBM exhibits distinct cellular and molecular patterns organized by anatomical niche, with malignant, vascular, and immune compartments showing region-specific spatial associations

  gbm glioma single-cell scrna-seq cite-seq spatial

• Multi-modal dissection of cell-type specific TDP-43 pathology in the motor cortex.

  PMID 41803120 · PMC12982666 · Nature communications · 2026 · 7 claims · 4 setups

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  Mainly excitatory cortical neurons are affected by TDP-43 pathology in the ALS/ALS-FTD motor cortex

  post-mortem publicly als single-nucleus single-nucleus spatial genotyping

• The mouse gastric surface epithelial cell and its response to early Helicobacter pylori infection.

  PMID 41824631 · PMC13020875 · Virulence · 2026 · 8 claims · 6 setups

  Has reproduction · 100

  SMCs show high gene expression for mucus-secreted proteins (Tff1, Gkn1, Gkn2, Psca, Muc5ac), mitoribosome RNA, and cytoskeleton proteins

  laser-microdissected gastric ffpe oct-embedded sequencing glycomics immunofluorescence

• Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair.

  PMID 39537633 · PMC11561360 · Nature communications · 2024 · 8 claims · 8 setups

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  A pharmacogenomic scoring strategy (OligoScore) combining transcriptomic signatures and curated oligodendrogenesis gene sets identifies compounds with pro-oligodendrogenic transcriptional activity

  brain neonatal gene cerebellar bulk transcriptomic pharmacogenomic

• Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization.

  PMID 41787818 · PMC13139821 · Allergy · 2026 · 8 claims · 8 setups

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  Basophils accumulate in wounded and oxazolone (OXA)-sensitized skin, peaking around day 3–6 post-injury

  skin ear dorsal mcpt8-ct single-cell flow rt-qpcr

• A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation-Dependent Cell Adhesion.

  PMID 41833005 · PMC13248847 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 7 claims · 8 setups

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  LSTs exhibit a more malignant phenotype than PAs, with higher inferred CNV scores, stronger genetic correlation with colorectal cancer, and downregulation of adhesion molecules

  patients bulk colorectal epithelial clinical bulk single-cell

• Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.

  PMID 41862476 · PMC13004862 · Nature communications · 2026 · 7 claims · 8 setups

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  Mechanical stress (MS) signaling is significantly elevated in endothelial cells (ECs) from IPF patients and correlates with fibrosis severity and lung function decline

  lung cd31+ single-nucleus scissor meta-analysis

• Establishment of a canine urothelial carcinoma-derived organoid biobank: A platform for comparative and translational research.

  PMID 41889014 · PMC13140855 · Clinical and translational medicine · 2026 · 8 claims · 6 setups

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  Canine urothelial carcinoma closely resembles human muscle-invasive bladder cancer in histopathology, molecular features, biological behavior, metastatic patterns, therapeutic response, and clinical outcome

  canine matched paired urine immunohistochemistry bulk single-nuclei

• Single-cell transcriptomics reveals keratinocyte dynamic processes associated with S100a4 expression in psoriasiform dermatitis.

  PMID 41660613 · PMC12876221 · Frontiers in immunology · 2025 · 7 claims · 8 setups

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  S100a4 knockout mice show significant pathological improvement in psoriasis-like lesions, including reduced inflammatory cell infiltration and decreased epidermal hyperplasia

  c57bl skin dorsal dcmo crispr western imiquimod-induced

• Dietary conjugated linoleic acid enhances resistance to Salmonella infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells.

  PMID 41964110 · PMC13078244 · Gut microbes · 2026 · 8 claims · 12 setups

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  Dietary CLA supplementation enhances host resistance to Salmonella Typhimurium infection

  ileal mice serum culture 16s untargeted bulk

• Spatiotemporal dynamics of spermatogenesis: insights from high-resolution spatial transcriptomics and pseudotime trajectories in mouse testes.

  PMID 41602862 · PMC12832764 · Frontiers in reproductive health · 2025 · 8 claims · 7 setups

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  Salus-STS (1 μm resolution) combined with the Salus Cellbins Algorithm enables accurate subcellular segmentation of individual testicular cells in dense tissue

  testicular testis seminiferous top high-resolution integration pseudotime

• Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination.

  PMID 41957119 · PMC13179334 · EMBO molecular medicine · 2026 · 7 claims · 8 setups

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  Serum vitamin D (25(OH)D3) levels are negatively associated with PSA levels in prostate cancer patients

  pca dlvp prostate facs-isolated clinical genetic immunohistochemistry

• Functional human salivary gland organoids for tissue regeneration in chemically defined culture systems.

  PMID 41707649 · PMC12923968 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  A chemically defined, Matrigel-free complete medium (CM) generates hSGOs with more cohesive spheroid morphology, organized epithelial layers, and improved apical polarization compared to keratinocyte medium (KM-S) or Matrigel-embedded conditions

  submandibular smg-derived hsgos smg bright-field h&e single-factor

• Aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in breast cancer.

  PMID 41719331 · PMC12933083 · Proceedings of the National Academy of Sciences of the United States of America · 2026 · 8 claims · 8 setups

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  Age at NMU exposure critically influences tumor incidence, mutational burden, molecular subtype, and the tumor immune microenvironment

  virgin mammary tcga-brca carcinogen-induced immunofluorescence bulk