Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue.

  PMID 41261284 · PMC12715258 · EMBO reports · 2025 · 8 claims · 8 setups

  Has reproduction · 78

  Imbalanced sympathetic/thermogenic activation (via UCP1 deficiency or pharmacological futile thermogenesis) causes BAT inflammation, fibrosis and degeneration

  bat wild-type brown histology qrt-pcr norepinephrine

• Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.

  PMID 27117818 · PMC4853423 · Nature communications · 2016 · 8 claims · 8 setups

  Has reproduction · 97

  Brown and beige adipocytes release exosomes, and thermogenic activation increases exosome release both in vitro and in vivo.

  brown tissues serum exosomes electron exosome mirna

• Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

  PMID 29400713 · PMC5839993 · Nature medicine · 2018 · 8 claims · 10 setups

  Has reproduction · 88

  Cold adaptation increases proteasomal activity in BAT, which is required for non-shivering thermogenesis

  bat body adipocytes mitochondria proteasomal core qpcr

• TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.

  PMID 33516944 · PMC7903014 · Molecular metabolism · 2021 · 7 claims · 8 setups

  Has reproduction

  BAT whitening at thermoneutrality is associated with TFEB-dependent mitochondrial degradation.

  bat subscapular tfeb-bat-ko metabolically qrt-pcr western immunohistochemistry