Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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A P4HA2 hypoxia signature derived from single cell atlas stratifies conserved subtypes with prognostic significance in cervical squamous cell carcinoma.
PMID 41559646 · PMC12910786 · BMC cancer · 2026 · 6 claims · 8 setups
A tumor cell metaprogram (MP7) identified from scRNA-seq of CSCC shows elevated hypoxia, invasion, metastasis, proliferation, and angiogenesis scores compared to other metaprograms.
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Has reproduction · 96
Hypoxia-associated genes as predictors of outcomes in gastric cancer: a genomic approach.
PMID 40129974 · PMC11931070 · Frontiers in immunology · 2025 · 8 claims · 8 setups
A prognostic model built from five H1-specific hypoxia-associated transcription factors (EHF, EIF1AD, GLA, KEAP1, MAGED2) predicts overall survival in STAD, with high-risk patients showing significantly worse OS.
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Hypoxia leads to reduced mito-nuclear gene expression and increased mtDNA transcriptional pausing in human cells.
PMID 41507516 · PMC12880982 · Communications biology · 2026 · 8 claims · 6 setups
Hypoxia induces a coordinated downregulation of mito-nuclear OXPHOS gene expression across most human cell lines tested
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Long non-coding RNA LINC00607 epigenetically regulates endothelial TSPAN18 to promote hypoxia-induced thromboinflammation.
PMID 41581880 · PMC12992942 · The Journal of biological chemistry · 2026 · 8 claims · 8 setups
LINC00607 is a hypoxia-inducible, endothelial-enriched lncRNA that positively regulates TSPAN18 expression
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Has reproduction · 61
Multi-omics analyses identify mannose phosphate isomerase-centered hypoxia-induced angiogenesis signature in colorectal cancer.
PMID 41204349 · PMC12595641 · Journal of translational medicine · 2025 · 8 claims · 8 setups
Twelve HIA-related genes were identified that are transcriptionally activated by HIF1A/HIF2A and functionally implicated in angiogenesis in CRC
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Has reproduction · 59
Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation.
PMID 35243257 · PMC8873613 · iScience · 2022 · 8 claims · 7 setups
Short-term stress and long-term adaptations share common metabolic pathways
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Hypoxia-Induced Osteopontin-Positive Glioma-Associated Macrophages Facilitate Glioma Mesenchymal Transition via NF-κB Pathway Activation.
PMID 41625475 · PMC12857759 · Cancer communications (London, England) · 2026 · 6 claims · 8 setups
A subset of GAMs with elevated OPN expression accumulates in response to hypoxic stimulation
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Single-Nucleus Multi-Omics Reveals Hypoxia-Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma.
PMID 41498635 · PMC12948189 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups
Five distinct malignant cell populations exist in SNSCC, with hypoxic (TC1) and proliferative (TC2) subtypes associated with adverse clinical outcomes.
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Has reproduction · 76
Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCD(cl1) Cells.
PMID 35806266 · PMC9267015 · International journal of molecular sciences · 2022 · 8 claims · 7 setups
mCCD cl1 cells mount a broad transcriptional response to 24 h hypoxia (0.2% O2), with 3086 genes differentially expressed
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Has reproduction · 73
GREIN: An Interactive Web Platform for Re-analyzing GEO RNA-seq Data.
PMID 31110304 · PMC6527554 · Scientific reports · 2019 · 8 claims · 7 setups
GREIN is a web application providing user-friendly interfaces to manipulate, visualize, and analyze GEO RNA-seq data.
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Has reproduction · 59
Identifying Molecular Subtypes and 6-Gene Prognostic Signature Based on Hypoxia for Optimizing Targeted Therapies in Non-Small Cell Lung Cancer.
PMID 35509605 · PMC9058021 · International journal of general medicine · 2022 · 8 claims · 8 setups
NSCLC samples can be classified into two molecular subtypes (C1 and C2) based on hypoxia-related gene expression via consensus clustering
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Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses, and reduced fitness†.
PMID 40874534 · PMC12808545 · Biology of reproduction · 2026 · 6 claims · 6 setups
IVF-conceived mouse placentae exhibit global and cell type–specific gene expression differences compared to FB placentae
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Has reproduction · 64
Spatial-reprogramming derived GPNMB(+) macrophages interact with COL6A3(+) fibroblasts to enhance vascular fibrosis in glioblastoma.
PMID 41174767 · PMC12577258 · Genome medicine · 2025 · 8 claims · 8 setups
COL6A3+ TAFs are a distinct matrix-fibroblast subset significantly enriched in non-responders to neoadjuvant antiangiogenic+ICB combination therapy
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Has reproduction · 68
Differential bone morphology and hypoxia activity in skeletal metastases of ER(+) and ER(-) breast cancer.
PMID 39572705 · PMC11582807 · Communications biology · 2024 · 8 claims · 8 setups
ER− MDA-MB-231 breast cancer forms more osteolytic bone metastases than ER+ MCF-7 breast cancer
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Has reproduction · 88
Tumor-specific but immunosuppressive CD39(+)CD8(+) T cells exhibit double-faceted roles in clear cell renal cell carcinoma.
PMID 40961944 · PMC12629791 · Cell reports. Medicine · 2025 · 8 claims · 8 setups
CD39+CD8+ TILs constitute a terminally exhausted, tumor-antigen-specific subset of CD8+ T cells
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Has reproduction · 73
ASTRA: a comprehensive resource of stress-induced transcriptional activity in human cell lines.
PMID 41263110 · PMC12807686 · Nucleic acids research · 2026 · 8 claims · 6 setups
ASTRA is a curated, open-access database cataloging transcriptomic stress responses in human cell lines across four stress categories (oxidative stress, hypoxia, heat shock, DNA damage/UV)
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DBTSS provides a tissue specific dynamic view of Transcription Start Sites.
PMID 19910371 · PMC2808897 · Nucleic acids research · 2010 · 8 claims · 8 setups
DBTSS update adds ~330 million new TSS Seq tags from 31 different human/mouse cell types or culture conditions.
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MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression.
PMID 42138560 · PMC13178401 · Comprehensive Physiology · 2026 · 8 claims · 7 setups
Hypoxia induces widespread transcriptomic remodeling in neonatal rat cardiomyocytes (385 DEGs vs normoxia)
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Cytoplasmic LIM domain only 2 enhances tumor endothelial cell migration through integrin β1-mediated focal adhesion signaling.
PMID 41639897 · PMC12983546 · Acta neuropathologica communications · 2026 · 8 claims · 8 setups
LMO2 is highly expressed in tumor-associated vasculature/endothelial cells compared with normal brain vasculature
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Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.
PMID 41741465 · PMC13057173 · Nature communications · 2026 · 8 claims · 7 setups
The MTOR eQTL variant rs4845987 has context-specific, opposite effects on MTOR expression: decreasing it in activated T cells and increasing it in neutrophils.