Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 14

System / cell line: cd8+ ✕ Assay: ifn-γ ✕ Clear

Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.

PMID 41735308 · PMC13043769 · Nature communications · 2026 · 8 claims · 8 setups

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OSGEP is the catalytic subunit of the KEOPS complex responsible for t6A modification at position 37 of cytoplasmic tRNAs, and its loss causes the highest protein aggregation among 45 screened tRNA-modifying enzymes in melanoma cells

mm117 b16f10 b16f10-derived c57bl esirna shrna rna-seq
Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines.

PMID 41811958 · PMC12978219 · Science advances · 2026 · 6 claims · 7 setups

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An integrated pipeline combining ML-based epitope prediction (netMHCpan, EpiDope, BepiPred), TCRpMHC structural modeling/docking, and JessEV vaccine design can prioritize viral peptides by immunogenicity, allele coverage, solubility, and stability.

preexposed alphaviral peptide-hla modeled peptide epitope structural
The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

PMID 41535474 · PMC12979199 · Nature · 2026 · 8 claims · 8 setups

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KLHL6 is a dual-negative regulator of both T cell exhaustion and mitochondrial dysfunction

cd8+ cas9+ sgklhl6-transduced klhl6 bulk pooled flow
Tumor-specific but immunosuppressive CD39(+)CD8(+) T cells exhibit double-faceted roles in clear cell renal cell carcinoma.

PMID 40961944 · PMC12629791 · Cell reports. Medicine · 2025 · 8 claims · 8 setups

Has reproduction · 88

CD39+CD8+ TILs constitute a terminally exhausted, tumor-antigen-specific subset of CD8+ T cells

memory sorted caix-specific cd39+pd-1bright scrna-seq bulk mhc
Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy.

PMID 33723257 · PMC7961017 · Nature communications · 2021 · 7 claims · 7 setups

Has reproduction · 70

Proportions of activated and proliferating CD8+ T cells (cluster C16/activated EM) are significantly higher in responders before and during therapy

pbmc cd3+cd8+ pbmc-derived metastatic high-dimensional single-cell polychromatic
PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.

PMID 33188038 · PMC7668369 · Journal for immunotherapy of cancer · 2020 · 7 claims · 6 setups

Has reproduction · 75

The frequency of circulating PD-1+TIGIT+ (DPOS) CD8+ T cells after 1 month of anti-PD-1 therapy is associated with clinical response and overall survival

pbmcs sorted expanded cancer multiparameter receptor targeted
Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

PMID 41416402 · PMC13136873 · Molecular cancer therapeutics · 2026 · 8 claims · 8 setups

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VitC conditioning enhances transduction efficiency and proliferative capacity, yielding a higher yield of CD4+ and CD8+ CAR19-Ts

cd3+ je6-1 car19-ts coculture flow nf-κb cytotoxicity
Candidate vaccine sequences to represent intra- and inter-clade HIV-1 variation.

PMID 19812689 · PMC2753653 · PloS one · 2009 · 7 claims · 5 setups

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Natural CTL immunodominance toward variable proteome regions increases epitope mismatch with challenge strains and recapitulates the escape-driven CTL failure seen in natural infection, contributing to HIV vaccine failure

hiv-1 polyclonally shannon cross-clade ctl
Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

PMID 37572656 · PMC10576612 · Immunity · 2023 · 8 claims · 8 setups

Has reproduction · 68

Arg1 is highly and specifically induced in lung CD4+ T cells during in vivo influenza infection

flow-sort-purified lung cd4+ congenically rna-seq flow expression
Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.

PMID 41387425 · PMC12701056 · Nature communications · 2025 · 8 claims · 8 setups

Has reproduction · 66

PON1 expression is downregulated in HCC tumor tissue and low PON1 is associated with worse prognosis

hcc paired hepa1-6 pon1-nc bioinformatic immunohistochemistry orthotopic
Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women.

PMID 40661959 · PMC12257036 · Frontiers in immunology · 2025 · 7 claims · 5 setups

Has reproduction · 87

NK cells show a sustained reduction during active SARS-CoV-2 infection and persisting after recovery in pregnant women

pbmcs serum 14-color single-cell 13-plex
A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells.

PMID 41484771 · PMC12882460 · Molecular cancer · 2026 · 7 claims · 5 setups

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Integration of pan-cancer scRNA-seq data yields a comprehensive single-cell atlas of 157,025 high-quality DNT cells across 23 cancer types.

tumor dnt ffpe mc38 scrna-seq tcr multiplex
Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

PMID 41533733 · PMC12829949 · PLoS pathogens · 2026 · 8 claims · 8 setups

Full-text index only

Aged Nr4a3-Tocky mice develop more severe pneumonia and delayed body weight recovery after SARS-CoV-2 infection than adult mice

nr4a3-tocky bronchoalveolar lung left viral histopathology immunohistochemistry
Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines.

PMID 19969118 · PMC2821965 · Vaccine · 2010 · 7 claims · 8 setups

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rMVA expressing multiple antigens under the mH5 promoter exhibit remarkable genetic stability and maintain potent immunogenicity after serial passage

rmva-infected individually bhk-21 pbmc qpcr western southern

Experiments

Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.

Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines.

The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

Tumor-specific but immunosuppressive CD39(+)CD8(+) T cells exhibit double-faceted roles in clear cell renal cell carcinoma.

Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy.

PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.

Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

Candidate vaccine sequences to represent intra- and inter-clade HIV-1 variation.

Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women.

A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells.

Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines.