Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 6

System / cell line: growth ✕ Assay: ifn-γ ✕ Clear

CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.

PMID 41564866 · PMC12866162 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

Full-text index only

CHD1 and MAP3K7 loss additively sensitizes cancer cells to IFN-γ-induced death

a375 crc-9 ht-29 vcap whole-genome autologous incucyte
Pharmacological perturbation of splicing elicits SMG1 reduction: Implications for cancer therapy.

PMID 41623476 · PMC12857400 · iScience · 2026 · 7 claims · 12 setups

Full-text index only

Splicing-modulatory drugs MS023 and indisulam act as inadvertent NMD inhibitors by downregulating SMG1 protein levels

4t1 tumor-draining arst panc02 mts tumor ifn-γ
A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling.

PMID 35729113 · PMC9213456 · Nature communications · 2022 · 7 claims · 5 setups

Has reproduction · 84

Developed a python-based, scalable model creation and simulation pipeline that converts structured text files into an SBML-standard model and is high-performance/cloud-computing ready.

sparced mcf10a deterministic hybrid comparison
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells.

PMID 32665556 · PMC7360550 · Nature communications · 2020 · 8 claims · 8 setups

Has reproduction · 50

Cancer cells in vivo display higher coherent orientation of MT dynamics along their major axis compared to 2D in vitro cultures

ht1080-eb3-mapple es2-eb3-mapple ht1080 cancer intravital live-cell confocal
Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.

PMID 41387425 · PMC12701056 · Nature communications · 2025 · 8 claims · 8 setups

Has reproduction · 66

PON1 expression is downregulated in HCC tumor tissue and low PON1 is associated with worse prognosis

hcc paired hepa1-6 pon1-nc bioinformatic immunohistochemistry orthotopic
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.

PMID 19789336 · PMC2927135 · Cancer research · 2009 · 8 claims · 8 setups

Full-text index only

K-RAS and N-RAS mutation status differentially determine the level of TNFα-induced apoptosis in an isogenic colon carcinoma cell panel

isogenic same conditioned dld-1 flow luminex immunoblot

Experiments

CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.

Pharmacological perturbation of splicing elicits SMG1 reduction: Implications for cancer therapy.

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling.

In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells.

Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.