Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

  PMID 41810957 · PMC13059739 · mBio · 2026 · 8 claims · 8 setups

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  IFN-γ signaling in T cells contributes to the development of malaria-associated lung pathology

  lungs pbnk65-infected cell-specific lung flow time-series qrt-pcr

• Single-cell analysis highlights the role of CD4(+) IFN-I-related T cells in Behcet's uveitis during Interferonα-2a therapy.

  PMID 42021381 · PMC13238117 · Biology direct · 2026 · 6 claims · 8 setups

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  CD4+ IFN-I-related T cells are significantly decreased in active BD patients and restored after IFNα-2a therapy

  pbmcs sorted skin scrna-seq scrna-seq bulk cell-cell

• The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8(+) T cells.

  PMID 41851343 · PMC13121605 · EMBO reports · 2026 · 8 claims · 8 setups

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  Progressive expression of KLRB1, KLRG1, GPR56, and KLRF1 tracks CD8+ T cell differentiation stages (TN, TCM, TEM, TEMRA), mirroring the pattern previously shown in CD4+ T cells

  unstimulated cd3+-enriched enriched cd8+ flow sorting-based spatial

• Development and validation of a potency assay matrix for optimized and consistent manufacture of clinical mesenchymal stem/stromal cells.

  PMID 41798920 · PMC12960169 · Frontiers in immunology · 2026 · 8 claims · 8 setups

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  MSCs consistently suppress T cell proliferation

  pbmcs cd4+ monocytes msc-conditioned suppression regulatory macrophage

• CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.

  PMID 41564866 · PMC12866162 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  CHD1 and MAP3K7 loss additively sensitizes cancer cells to IFN-γ-induced death

  a375 crc-9 ht-29 vcap whole-genome autologous incucyte

• Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine-Dependent Pro-Inflammatory Immune Microenvironment.

  PMID 41580972 · PMC13042394 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  T cell-specific Socs1 loss intrinsically drives pro-inflammatory T cell differentiation independent of antigen stimulation, with the strongest effects in CD8+ T cells

  cd45+ splenic cd8+ sorted single-cell flow bulk

• Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model.

  PMID 41779856 · PMC12959402 · Science advances · 2026 · 7 claims · 6 setups

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  Lung tumors drive expansion of both CD27+ and CD27- pulmonary γδ T cells, which acquire distinct spatial and phenotypic changes in the tumor microenvironment

  spc-cre+ microdissected sorted merged flow confocal single-cell

• The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

  PMID 41535474 · PMC12979199 · Nature · 2026 · 8 claims · 8 setups

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  KLHL6 is a dual-negative regulator of both T cell exhaustion and mitochondrial dysfunction

  cd8+ cas9+ sgklhl6-transduced klhl6 bulk pooled flow

• TOPK Suppresses the CD8(+) T Cell Antitumor Immunity via Modulation of IRF5 Expression.

  PMID 41868885 · PMC13003159 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups

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  A TOPK+ subset of tumor-infiltrating CD8+ T cells exists in melanoma at higher frequency than in normal lymph nodes and shows suppressed cytotoxic/cytokine programs.

  tumor-infiltrating melanoma b16-f10 unspecified scrna-seq flow multiplex

• Tumor-specific but immunosuppressive CD39(+)CD8(+) T cells exhibit double-faceted roles in clear cell renal cell carcinoma.

  PMID 40961944 · PMC12629791 · Cell reports. Medicine · 2025 · 8 claims · 8 setups

  Has reproduction · 88

  CD39+CD8+ TILs constitute a terminally exhausted, tumor-antigen-specific subset of CD8+ T cells

  memory sorted caix-specific cd39+pd-1bright scrna-seq bulk mhc

• Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

  PMID 41416402 · PMC13136873 · Molecular cancer therapeutics · 2026 · 8 claims · 8 setups

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  VitC conditioning enhances transduction efficiency and proliferative capacity, yielding a higher yield of CD4+ and CD8+ CAR19-Ts

  cd3+ je6-1 car19-ts coculture flow nf-κb cytotoxicity

• Metabolic adaptations rewire CD4(+) T cells in a subset-specific manner in human critical illness with and without sepsis.

  PMID 41540263 · PMC12864044 · Nature immunology · 2026 · 8 claims · 7 setups

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  CD4+ T cells in critical illness show subset-specific metabolic plasticity, with regulatory T (Treg) cells preferentially acquiring glycolytic capacity

  pbmc-derived peripheral cd4+ puromycin-incorporation complete expression

• Transient tumor exposure induces persistent functional defects in memory CD8(+) T cells.

  PMID 42023146 · PMC13098610 · iScience · 2026 · 8 claims · 8 setups

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  Memory CD8+ T cells generated after transient tumor rejection (Tum-CD8+) display a distinct, partially exhausted phenotype compared to virus-induced memory cells (Vir-CD8+)

  cd45.1 single-cell memory ctv flow single-cell cytokine

• Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

  PMID 42081487 · PMC13262731 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  BCG responders show an increase in Th17-like Th1 CD4+ T cells with greater proinflammatory cytokine expression

  bladder pbmcs cd4+ separate scrna-seq trajectory flow

• Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy.

  PMID 33723257 · PMC7961017 · Nature communications · 2021 · 7 claims · 7 setups

  Has reproduction · 70

  Proportions of activated and proliferating CD8+ T cells (cluster C16/activated EM) are significantly higher in responders before and during therapy

  pbmc cd3+cd8+ pbmc-derived metastatic high-dimensional single-cell polychromatic

• PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.

  PMID 33188038 · PMC7668369 · Journal for immunotherapy of cancer · 2020 · 7 claims · 6 setups

  Has reproduction · 75

  The frequency of circulating PD-1+TIGIT+ (DPOS) CD8+ T cells after 1 month of anti-PD-1 therapy is associated with clinical response and overall survival

  pbmcs sorted expanded cancer multiparameter receptor targeted

• Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

  PMID 41533733 · PMC12829949 · PLoS pathogens · 2026 · 8 claims · 8 setups

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  Aged Nr4a3-Tocky mice develop more severe pneumonia and delayed body weight recovery after SARS-CoV-2 infection than adult mice

  nr4a3-tocky bronchoalveolar lung left viral histopathology immunohistochemistry

• Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

  PMID 41563843 · PMC7618831 · Cancer immunology research · 2026 · 8 claims · 8 setups

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  iPDCs cultured on human omentum gel (OmGel) recapitulate tumor genomic and histologic characteristics while retaining intratumoral immune cells

  formalin-fixed blood dissociated ipdcs histopathology whole-exome flow

• Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy.

  PMID 41680482 · PMC12920136 · Nature medicine · 2026 · 7 claims · 7 setups

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  Anti-PD-1 therapy triggers a rapid (within 24 hours) systemic cascade of increased IFN/antiviral, monocyte, and CD8+ T cell effector transcriptomic modules alongside decreased plasma TGFβ.

  pbmcs plasma pbmc publicly bulk plasma integrated

• CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.

  PMID 41746743 · PMC13078883 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  CD38 is markedly more highly expressed on cord blood (CB) naive CD4+ T cells than adult blood (AB) naive CD4+ T cells, with an age-dependent gradient from fetal to pediatric life.

  pbmcs sorted scrna-seq naive flow bulk compass