Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.
PMID 41907400 · PMC13018967 · iScience · 2026 · 8 claims · 8 setups
Colorectal cancer fibroblast heterogeneity can be distilled into two overarching, transcriptomically distinct CAF populations marked by PDGFRA+ and ACTA2+ expression
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Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris.
PMID 41657309 · PMC12892907 · JCI insight · 2026 · 8 claims · 6 setups
A custom KRT5-directed segmentation pipeline improves transcript assignment accuracy in the spatially complex sebaceous gland compared with standard multimodal or nuclei-expansion segmentation
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ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma.
PMID 42009652 · PMC13096517 · Cell discovery · 2026 · 8 claims · 8 setups
PKM2 is upregulated and PKM1 is downregulated in human and murine PDAC tumors relative to normal pancreas
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Resolving sensitivity, specificity and signal contamination in Xenium spatial transcriptomics.
PMID 42062553 · PMC13259927 · Nature methods · 2026 · 8 claims · 6 setups
Xenium data show strong consistency across patients and technical replicates, with little technical variation between platforms
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Single-cell and spatial transcriptomics analyses reveal tumor microenvironment-driven proliferation of NF2-associated vestibular schwannomas.
PMID 41957607 · PMC13200446 · Journal of neuroinflammation · 2026 · 8 claims · 7 setups
NF2-VS tumors comprise 12 major cell lineages with distinct TME composition between Gardner and Wishart phenotypes
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A high-resolution spatial map of cilia-associated proteins in the human fallopian tube.
PMID 42010243 · PMC13096173 · Nature communications · 2026 · 6 claims · 7 setups
310 genes show elevated expression in the human fallopian tube compared to other tissues, the majority associated with motile cilium structure/function.
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Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor.
PMID 42057139 · PMC13130799 · Biomarker research · 2026 · 8 claims · 8 setups
Tumor areas of TSCST show significantly low expression of immune cell genes, indicating an immune-cold tumor microenvironment
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Has reproduction · 90
Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies.
PMID 40849297 · PMC12375038 · Nature communications · 2025 · 8 claims · 8 setups
Multi-omic profiling (snRNA-seq + spatial transcriptomics) of human sural nerves identifies novel cell type markers (MLIP in mySC; GRIK3, PRIMA1 in nmSC; CXCL14 in periC) not previously described in rodent or human literature
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M(5)C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance.
PMID 41673397 · PMC12921336 · Cell death & disease · 2026 · 8 claims · 8 setups
RNA m5C levels are globally and consistently elevated in cervical tumors compared to normal cervical tissue
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Has reproduction · 50
Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma.
PMID 37320872 · PMC10277597 · Translational oncology · 2023 · 8 claims · 9 setups
Seven distinct CAF subsets exist in HNSCC, identified via integration of scRNA-seq, bulk transcriptomic, and spatial transcriptomic data.
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Has reproduction · 68
Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition.
PMID 35819852 · PMC9433101 · The Journal of clinical investigation · 2022 · 8 claims · 8 setups
Chronic wound-edge tissue shows genome-wide DNA hypermethylation compared with unwounded skin
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CLK1 Promotes Myeloid-Derived Suppressor Cell Trafficking and Reprograms the Tumor Microenvironment by Activating Hippo/YAP Signaling in Colorectal Cancer.
PMID 41686262 · PMC13136879 · Cancer immunology research · 2026 · 8 claims · 8 setups
CLK1 is markedly upregulated in immune-cold colorectal tumors and correlates with increased MDSC infiltration and CD8+ T-cell exclusion
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AJUBA: The Master Regulator Bridging EMT and Immune Evasion in Colorectal Cancer.
PMID 41814682 · PMC13140425 · Mediators of inflammation · 2026 · 8 claims · 8 setups
AJUBA is markedly upregulated in CRC across multiple transcriptomic cohorts and is enriched in epithelial cells with activated EMT features
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Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis.
PMID 41927532 · PMC13046724 · Bone research · 2026 · 8 claims · 8 setups
Spatially resolved osteoblast-traced transcriptomics (lineage tracing + SLACS) identifies TGF-β signaling as a regulator of osteoblast activation state on quiescent bone surfaces
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Has reproduction · 76
Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs.
PMID 38781959 · PMC11228554 · Cell reports. Medicine · 2024 · 8 claims · 8 setups
DSRCT tumor cells cluster into consistent subpopulations with partially overlapping lineage- and metabolism-related transcriptional programs across patients and samples
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Has reproduction · 73
FRMD8 inhibits tumor metastasis in BRCA1-associated TNBC by negatively regulating tmTNF-α.
PMID 40619383 · PMC12229025 · Cellular & molecular biology letters · 2025 · 8 claims · 8 setups
Low FRMD8 expression in BRCA1-mutant breast cancer cells significantly enhances metastatic potential to various organs
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PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1-KDM5C-IL6 Axis in ccRCC.
PMID 41514194 · PMC13042695 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups
PBRM1 deficiency increases infiltration of immunosuppressive M2 tumor-associated macrophages (TAMs) and creates an immune-excluded tumor microenvironment
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Has reproduction · 83
Multimodal data integration for biologically-relevant artificial intelligence to guide adjuvant chemotherapy in stage II colorectal cancer.
PMID 40472802 · PMC12171563 · EBioMedicine · 2025 · 6 claims · 7 setups
AI-derived radiological clustering identifies stage II CRC patients with significantly different survival benefit from adjuvant chemotherapy
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Genomic and Immune Landscape of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Progressing on Anti-PD-1 Treatment.
PMID 41666253 · PMC13044521 · Cancer immunology research · 2026 · 6 claims · 8 setups
Tumor biopsies from anti-PD-1-resistant SCCHN show significantly more EGFR and MYCL amplifications and increased MYC pathway alterations compared with anti-PD-1-naive tumors
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Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers.
PMID 41484081 · PMC12858953 · Nature communications · 2026 · 8 claims · 8 setups
Combined low-dose CTX + anti-CSF-1R (SNDX-ms6352) is highly effective against aggressive metastatic Trp53-null TNBC models with high macrophage infiltration, producing complete tumor regression in claudin-low models.