Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 19

System / cell line: immune ✕ Assay: imaging ✕ Clear

Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers.

PMID 41484081 · PMC12858953 · Nature communications · 2026 · 8 claims · 8 setups

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Combined low-dose CTX + anti-CSF-1R (SNDX-ms6352) is highly effective against aggressive metastatic Trp53-null TNBC models with high macrophage infiltration, producing complete tumor regression in claudin-low models.

trp53-null complete t12 cell-deficient imaging survival tumor
TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis.

PMID 41492090 · PMC12858408 · Nature cancer · 2026 · 7 claims · 8 setups

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TGFβ initially induces a full, typical EMT (stress fibers, loss of epithelial markers, motility) in dormancy-competent LUAD progenitors that subsequently transitions into an atypical spheroidal mesenchymal state lacking actin stress fibers.

h2087-lcc m802t4-lcc reconstructed immunofluorescence antibody-mediated
Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression.

PMID 41610471 · PMC12874334 · Neoplasia (New York, N.Y.) · 2026 · 8 claims · 7 setups

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Chronic HDM exposure accelerates lung tumor growth through non-mutagenic, immune-mediated mechanisms

orthotopic lung beas-2b tumor bioluminescence h&e viability
TNF-⍺-mediated myeloid-instructed CD14(+)CD4(+) T cells are associated with poor survival in lung adenocarcinoma.

PMID 41666923 · PMC12923953 · Cell reports. Medicine · 2026 · 8 claims · 5 setups

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Tumors stratify into lymphoid-enriched, myeloid-enriched, and mixed immune-infiltrated subtypes independent of oncogenic driver status

resected luad cd4+ multiplex spatial image
Precancerous niche remodelling dictates nascent tumour persistence.

PMID 41781610 · PMC13148994 · Nature · 2026 · 8 claims · 8 setups

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Newly emerging tumours actively remodel their surrounding stroma into a 'precancerous niche' that determines their long-term survival.

upper nascent oesophagus carcinogen-free immunofluorescence edu immune
Intestinal macrophages modulate synucleinopathy along the gut-brain axis.

PMID 41606336 · PMC12960212 · Nature · 2026 · 8 claims · 8 setups

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ME-Macs engulf misfolded, aggregated αS and modulate αS pathology and neurodegeneration in PD mouse models

3kl sorted me-macs snca immunohistochemistry digital mass
Genomic and Immune Landscape of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Progressing on Anti-PD-1 Treatment.

PMID 41666253 · PMC13044521 · Cancer immunology research · 2026 · 6 claims · 8 setups

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Tumor biopsies from anti-PD-1-resistant SCCHN show significantly more EGFR and MYCL amplifications and increased MYC pathway alterations compared with anti-PD-1-naive tumors

ffpe blood tumor whole-exome bulk multiplex
The Aging Microenvironment Is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer.

PMID 41202211 · PMC12768431 · Cancer research · 2026 · 8 claims · 8 setups

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Organismal aging accelerates PDAC progression and metastatic burden in an age-relevant syngeneic orthotopic mouse model

kpc4662 orthotopic pdac pancreatic orthotopic heterochronic ultrasound
Clonal CD8(+) T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases.

PMID 41593242 · PMC12864034 · Nature immunology · 2026 · 8 claims · 6 setups

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The human leptomeninges harbor substantial numbers of clonally expanded, tissue-resident memory CD8 T cells (ZNF683-high, CXCR6+, PD-1+)

postmortem leptomeninges scrna-seq-derived leptomeningeal single-cell flow imaging
Identification of markers correlating with mitochondrial function in myocardial infarction by bioinformatics.

PMID 39775580 · PMC11684664 · PloS one · 2024 · 7 claims · 8 setups

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MitoDEGs in MI are mainly involved in mitochondrial function and ATP synthesis pathways

left mus combined heart microarray weighted bulk
Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

PMID 41639447 · PMC12935554 · Nature · 2026 · 8 claims · 8 setups

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Lung adenocarcinoma (LUAD) induces increased innervation and functional/transcriptional engagement of vagal sensory neurons (VSNs)

kras-g12d tumour-bearing vagal npy2r-ires-cre whole-mount aav neurite
Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events.

PMID 41254329 · PMC12627558 · Communications medicine · 2025 · 7 claims · 6 setups

Has reproduction · 71

Blood of steroid non-responders shows elevated Tc1/Tc17 CD8+ T cells and Th1/Th17-associated interleukins before steroid initiation

pbmcs pbmc serum snap-frozen spectral pd-1 ici-bound
Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology.

PMID 39941893 · PMC11817449 · Cancers · 2025 · 8 claims · 7 setups

Has reproduction · 50

A standardized, reproducible protocol can establish meningioma organoids (MEN-Os) from patient-resected tumor tissue without mechanical/enzymatic dissociation, using serum-free medium lacking growth factors or exogenous ECM.

patient-resected men-os parent oct-embedded organoid brightfield h&e
Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

PMID 41563843 · PMC7618831 · Cancer immunology research · 2026 · 8 claims · 8 setups

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iPDCs cultured on human omentum gel (OmGel) recapitulate tumor genomic and histologic characteristics while retaining intratumoral immune cells

formalin-fixed blood dissociated ipdcs histopathology whole-exome flow
Multimodal data integration for biologically-relevant artificial intelligence to guide adjuvant chemotherapy in stage II colorectal cancer.

PMID 40472802 · PMC12171563 · EBioMedicine · 2025 · 6 claims · 7 setups

Has reproduction · 83

AI-derived radiological clustering identifies stage II CRC patients with significantly different survival benefit from adjuvant chemotherapy

stage patients tumour whole-tumour radiomics bulk cellular
Development of double-positive thymocytes at single-cell resolution.

PMID 33771202 · PMC8004397 · Genome medicine · 2021 · 7 claims · 8 setups

Has reproduction · 86

DP thymocytes can be classified into blast, rearrangement, and selection subtypes, distinguishable by surface markers CD2 and Ly6d

thymocytes sorted thymocyte scrna-seq flow immunofluorescence
TiRank prioritizes phenotypic niches in tumor microenvironment for clinical biomarker discovery.

PMID 41689080 · PMC12910759 · Genome medicine · 2026 · 7 claims · 4 setups

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TiRank is a framework that integrates scRNA-seq, ST, and bulk transcriptomes using an REO-transformation module and multitask transfer learning to align data into a unified embedding space for prioritizing clinically relevant spatial niches

benchmark pan-cancer gastric independent scrna-seq bulk spatial
Indoleamine 2, 3-Dioxygenase 1 and CD8 Expression Profiling Revealed an Immunological Subtype of Colon Cancer With a Poor Prognosis.

PMID 33425745 · PMC7793995 · Frontiers in oncology · 2020 · 8 claims · 8 setups

Has reproduction · 48

A colon cancer subtype with CD8Ahigh IDO1high tumors shows the worst survival despite high CD8 T cell infiltrates

tcga-coad ncbi-geo tisidb gepia rna-seq tumor-infiltrating gene
Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia.

PMID 37217248 · PMC10231005 · Journal for immunotherapy of cancer · 2023 · 8 claims · 8 setups

Has reproduction · 76

High expression of IFN-I signaling/response genes (IFNAR1, IFNAR2, STAT1, MX1, OAS1) predicts favorable relapse-free survival in B-ALL patients

cog b-all eμ-myc crispra gene-expression-based flow mass

Experiments

Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers.

TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis.

Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression.

TNF-⍺-mediated myeloid-instructed CD14(+)CD4(+) T cells are associated with poor survival in lung adenocarcinoma.

Precancerous niche remodelling dictates nascent tumour persistence.

Intestinal macrophages modulate synucleinopathy along the gut-brain axis.

Genomic and Immune Landscape of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Progressing on Anti-PD-1 Treatment.

The Aging Microenvironment Is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer.

Clonal CD8(+) T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases.

Identification of markers correlating with mitochondrial function in myocardial infarction by bioinformatics.

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events.

Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology.

Ex Vivo Immuno-Oncology Platform Reveals Spatial T-cell Infiltration Patterns Linked to ATR Inhibition Responses in High-Grade Serous Ovarian Cancer.

Multimodal data integration for biologically-relevant artificial intelligence to guide adjuvant chemotherapy in stage II colorectal cancer.

Development of double-positive thymocytes at single-cell resolution.

TiRank prioritizes phenotypic niches in tumor microenvironment for clinical biomarker discovery.

Indoleamine 2, 3-Dioxygenase 1 and CD8 Expression Profiling Revealed an Immunological Subtype of Colon Cancer With a Poor Prognosis.

Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia.