Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota.
PMID 41826553 · PMC13076647 · EMBO reports · 2026 · 8 claims · 8 setups
Generated a novel Paneth-cell-specific SIRT1 knockout mouse model (SIRT1 PKO, Sirt1 f/f;Defa6-Cre+)
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Has reproduction · 83
A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients.
PMID 36694043 · PMC9873918 · Communications biology · 2023 · 8 claims · 8 setups
Disease-specific temporal (dynamic) gene expression and splicing signatures, distinct from fixed timepoint differential expression, can be derived from DSS and adoptive transfer colitis models to capture acute-chronic disease dynamics
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Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing.
PMID 41651833 · PMC12988232 · Nature communications · 2026 · 8 claims · 8 setups
IPA is consistently depleted in IBD/colitis patients and in murine colitis models relative to healthy controls
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Dietary conjugated linoleic acid enhances resistance to Salmonella infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells.
PMID 41964110 · PMC13078244 · Gut microbes · 2026 · 8 claims · 12 setups
Dietary CLA supplementation enhances host resistance to Salmonella Typhimurium infection