Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 101

Assay: immunoblot ✕ Clear

Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: proteomic analysis of human synaptosomes.

PMID 19693676 · PMC2824116 · Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010 · 8 claims · 7 setups

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Proteomic screening of human synaptosomes identifies a set of proteins differentially expressed in HIV/AIDS brain

frontal excised synaptosome paraffin-embedded 2d-page maldi-tof western
Global proteome analysis of Leptospira interrogans.

PMID 19663501 · PMC2757032 · Journal of proteome research · 2009 · 8 claims · 5 setups

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563 proteins were identified in L. interrogans via combined iTRAQ and 2DGE proteomic analysis

leptospira serum liver itraq two-dimensional immunoblot
Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.

PMID 19649643 · PMC3104467 · Acta neuropathologica · 2010 · 8 claims · 8 setups

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GRN transcript haploinsufficiency, previously shown in blood-derived cells, does not hold in most brain regions of GRN mutation carriers

peripheral postmortem hek293 qrt-pcr microarray rt-pcr
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.

PMID 37831779 · PMC10575592 · Science advances · 2023 · 8 claims · 8 setups

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Acquired resistance to sotorasib in isogenic cells correlates with increased ITGB4 expression

h358 h23 sw1573 proliferation spheroid immunoblot
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.

PMID 41820368 · PMC13121600 · Nature communications · 2026 · 8 claims · 8 setups

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CBFB (CBF-β) is a synthetic lethal interactor of VHL in ccRCC cell lines

786o ccrcc tcga genome-wide competitive immunoblot
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.

PMID 41606307 · PMC12945694 · Nature metabolism · 2026 · 8 claims · 8 setups

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Lamin A/C represses cysteine biosynthesis and catabolism in naive mES cells by suppressing CTH and CBS

mes metabolomics atac-seq chip-qpcr
In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen.

PMID 41634022 · PMC12966279 · Nature communications · 2026 · 8 claims · 8 setups

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Dual RNA-Seq of L. interrogans-infected hamsters reveals the in vivo host-pathogen transcriptomic landscape during infection

golden interrogans hamster epithelial dual rna-seq qpcr
HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.

PMID 41714613 · PMC12921326 · Nature communications · 2026 · 8 claims · 8 setups

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HIF-2α mRNA is specifically overexpressed in ccRCC tumor tissue/cells compared to normal kidney, while it is reduced in papillary and chromophobe RCC

erlangen tcga ccrcc tubule qpcr rna-seq rnascope
Splice-switching of the oncogenic BCS1L isoform suppresses ovarian cancer progression by disrupting mitochondrial function.

PMID 41771836 · PMC13039997 · Cell death & disease · 2026 · 7 claims · 8 setups

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BCS1L is alternatively spliced into a full-length isoform (BCS1L-L) and an exon 2-skipped short isoform (BCS1L-S)

tcga-ov ovarian clinical fte187 gsea single-cell qpcr
SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.

PMID 41807550 · PMC13249849 · NPJ precision oncology · 2026 · 8 claims · 8 setups

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MCL1 inhibition is synthetic lethal with SMARCA4/2 loss in SCCOHT and NSCLC cells

nsclc lung smarca4 bin-67 genome-wide drug colony
Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity.

PMID 41851118 · PMC13153255 · Nature communications · 2026 · 8 claims · 7 setups

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BAP1 (PR-DUB catalytic subunit) restricts pervasive, genome-wide H2AK119ub1 accumulation in mouse oocytes

zygotes oocytes fgo fgos microinjection bulk western
Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.

PMID 41882353 · PMC13216075 · Nature · 2026 · 8 claims · 8 setups

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GluN1 and GluN2B NMDAR subunits are ectopically expressed in cancer cells of human TNBC tumours

breast tnbc 4t1-nmdar orthotopic bulk spatial immunofluorescence
Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4.

PMID 41908886 · PMC13017157 · Neuro-oncology pediatrics · 2026 · 8 claims · 6 setups

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Alternative splicing defines biologically and prognostically meaningful tumor subgroups in pediatric CNS tumors beyond traditional histologic classification

pediatric kns-42 genome-wide grouped qrt-pcr
Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina.

PMID 41950290 · PMC13095125 · PLoS genetics · 2026 · 8 claims · 8 setups

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Enhanced ATP production during mouse retinal development is achieved primarily through an increase in glycolysis rather than mitochondrial respiration.

retina histones histone retinal seahorse lactate-glo ldh
SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

PMID 41951591 · PMC13237135 · Nature communications · 2026 · 8 claims · 8 setups

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RPT2 domain missense mutations disrupt SMARCB1 antiproliferative function by destabilizing the SWI/SNF complex and impairing chromatin remodeling and transcriptional regulation, comparable to nonsense mutations

g401 smarcb1 cohorts proliferation-based inducible immunoblot
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis.

PMID 41951665 · PMC13237010 · Nature communications · 2026 · 8 claims · 8 setups

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RPL5 haploinsufficiency causes HSPC accumulation and prenatal lethality via p53-mediated ferroptosis of mature erythroid progenitors

hematopoietic peripheral liver fetal crispr-cas9 complete histology
Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination.

PMID 41957119 · PMC13179334 · EMBO molecular medicine · 2026 · 7 claims · 8 setups

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Serum vitamin D (25(OH)D3) levels are negatively associated with PSA levels in prostate cancer patients

pca dlvp prostate facs-isolated clinical genetic immunohistochemistry
Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.

PMID 41980976 · PMC13079744 · Nature communications · 2026 · 8 claims · 8 setups

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Loss of ALDH3B1 impairs 2-HD detoxification and causes retinal vascular abnormalities in zebrafish without affecting trunk vasculature

zebrafish crispr quantitative immunoblot
Helicobacter pylori-induced PPFIA4 orchestrates immune network-promoting gastritis and gastric bacterial colonization.

PMID 42065246 · PMC13132368 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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PPFIA4 is increased in GECs from gastric mucosa of H. pylori-infected patients and mice

ags gastric il33 slam-seq scrna-seq western
Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass.

PMID 18824761 · PMC2629397 · Circulation · 2008 · 8 claims · 3 setups

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CP/CPB causes multiple consistent, reproducible changes in the human myocardial (right atrial) protein profile

right excised 2-dimensional tandem sds-page

Experiments

Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: proteomic analysis of human synaptosomes.

Global proteome analysis of Leptospira interrogans.

Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.

Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.

In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen.

HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.

Splice-switching of the oncogenic BCS1L isoform suppresses ovarian cancer progression by disrupting mitochondrial function.

SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.

Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity.

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.

Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4.

Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina.

SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis.

Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination.

Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.

Helicobacter pylori-induced PPFIA4 orchestrates immune network-promoting gastritis and gastric bacterial colonization.

Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass.