Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Identification and validation of prognostic genes associated with M2 macrophage and heme metabolism in lung adenocarcinoma through bulk and single-cell RNA sequencing analysis.

  PMID 41787185 · PMC13076703 · Discover oncology · 2026 · 8 claims · 8 setups

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  EPB41, ACP5, PPOX, RBM38, and TRIM58 were identified as prognostic genes for LUAD

  tcga-luad gse131907 clinical cibersort gsea spearman

• Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization.

  PMID 41787818 · PMC13139821 · Allergy · 2026 · 8 claims · 8 setups

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  Basophils accumulate in wounded and oxazolone (OXA)-sensitized skin, peaking around day 3–6 post-injury

  skin ear dorsal mcpt8-ct single-cell flow rt-qpcr

• The complement system contributes to the immunosuppressive microenvironment of uveal melanoma.

  PMID 41803879 · PMC13130498 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  Primary UM (pUM) preferentially expresses early complement pathway components over terminal membrane attack complex elements, with early factors showing prognostic significance.

  short-term metastatic normal pum bulk label-free single-cell

• Fibroblast-associated CTHRC1 as a key indicator of recurrence risk in prostate cancer.

  PMID 41832493 · PMC13101373 · World journal of surgical oncology · 2026 · 7 claims · 8 setups

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  Pathological T stage, N stage, Gleason score, and TP53 mutation are associated with higher PRAD recurrence risk

  tcga geo prad scrna-seq bulk single-cell cell-cell

• A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation-Dependent Cell Adhesion.

  PMID 41833005 · PMC13248847 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 7 claims · 8 setups

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  LSTs exhibit a more malignant phenotype than PAs, with higher inferred CNV scores, stronger genetic correlation with colorectal cancer, and downregulation of adhesion molecules

  patients bulk colorectal epithelial clinical bulk single-cell

• CEBPB-Regulated Gastric Cell Plasticity Promotes Liver Metastasis of Gastric Cancer.

  PMID 41836678 · PMC12981248 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups

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  GC cells undergoing liver metastasis transcriptionally reprogram into a high-plasticity cell state

  tumor lines nci-n87 balb single-cell epigenomics transwell

• A differential single-cell transcriptome atlas of left-sided and right-sided colorectal cancer.

  PMID 41844817 · PMC13111741 · Discover oncology · 2026 · 8 claims · 8 setups

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  MTRNR2L8 is markedly upregulated in RCRC tumor cells and is associated with poorer patient survival

  crc epithelial rcrc tcga-read scrna-seq copy gene

• Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

  PMID 41850280 · PMC13103949 · Cell reports · 2026 · 8 claims · 8 setups

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  Chemotherapy-resistant KT-47R tumors show blastemal predominance and reduced stromal content compared to pre-treatment KT-47PT

  kt-47 kt-47pt histology whole-exome cut&tag

• Machine learning-driven transcriptomic and single-cell profiling of programed cell death patterns in colon cancer.

  PMID 41854308 · PMC13009810 · Science progress · 2026 · 8 claims · 8 setups

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  Disulfidptosis and anoikis are consistently identified as the most robust prognostic PCD patterns in colon cancer across six independent machine learning algorithms

  colon coad ssgsea-based machine differential

• Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.

  PMID 41858622 · PMC12995703 · iScience · 2026 · 8 claims · 8 setups

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  Cdkn1a and Pdk1 are key PANoptosis-related genes with high diagnostic potential for AILI

  liver training bulk wgcna machine

• Single-cell transcriptomic analysis reveals intra-tumoral heterogeneity and immunotherapy strategies in high-grade serous ovarian cancer.

  PMID 41907410 · PMC13018870 · iScience · 2026 · 8 claims · 8 setups

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  scRNA-seq of 17 HGSOC tissue samples reveals seven major cell types and extensive intra-tumoral heterogeneity

  hgsoc epithelial tcga gse165897 single-cell copy kegg

• Integrative multimodal transcriptomics identifies a cancer-associated fibroblast membrane signature for predicting prognosis and therapeutic response in pancreatic ductal adenocarcinoma.

  PMID 41942785 · PMC13053443 · Journal of molecular medicine (Berlin, Germany) · 2026 · 8 claims · 8 setups

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  A PDAC-enriched myoCAF-c1 fibroblast cluster is closely associated with epithelial-mesenchymal transition (EMT) and angiogenesis

  pdac myocaf-c1-derived tcga-paad scrna-seq spatial bulk

• Targeting KIFC1 to disrupt centrosome clustering and trigger anaphase catastrophe in small-cell lung cancer.

  PMID 41948931 · PMC13134724 · JCI insight · 2026 · 8 claims · 8 setups

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  KIFC1 is overexpressed in SCLC compared with normal tissues and other cancer types

  sclc h146 clinical cancer immunofluorescence viability flow

• Cross-tissue atlas of mucosa-associated lymphoid tissue lymphomas reveals intratumoral heterogeneity and microenvironmental subtypes.

  PMID 42066772 · PMC13198276 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  Integrative bulk, single-nucleus, and spatial RNA-seq analysis identifies three LME subtypes in MALT lymphoma: LME1 (mesenchymal), LME2 (inflammatory), and LME3 (depleted).

  malt ffpe snrna-seq-derived snrna-seq bulk single-nucleus spatial