Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 38

System / cell line: clinical ✕ Assay: immunohistochemistry ✕ Clear

MSI test to distinguish between HNPCC and other predisposing syndromes -- of value in tailored surveillance.

PMID 15528791 · PMC3839337 · Disease markers · 2004 · 8 claims · 5 setups

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MSI (or immunohistochemistry) testing applied to a pre-selected patient with a family history or early-onset colorectal cancer can distinguish HNPCC from unknown non-HNPCC colorectal cancer syndromes.

population-based swedish colorectal hnpcc clinical histopathological microsatellite
Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours.

PMID 17299397 · PMC2360083 · British journal of cancer · 2007 · 8 claims · 5 setups

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A combined VEGF-A ligand and flt-1 receptor protein expression signature discriminates malignant from benign GIST

archival tma genomic pcr immunohistochemistry unsupervised pcr-dhplc
Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1.

PMID 18580586 · PMC2750842 · Alzheimer disease and associated disorders · 2008 · 8 claims · 8 setups

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The PSEN1 N135S mutation causes EOFAD with an atypical phenotype including spastic dysarthria, limb spasticity, and seizures in addition to typical cognitive deficits

archival medulla cortex hippocampus immunohistochemistry thioflavin-s pcr
Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage.

PMID 15494720 · PMC2409947 · British journal of cancer · 2004 · 8 claims · 7 setups

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Significant overexpression of p53 protein was found in 48% of 74 astrocytic tumours

archival subset recombinant same immunohistochemistry antibody cytokeratin
A novel POMT2 mutation causes mild congenital muscular dystrophy with normal brain MRI.

PMID 18804929 · PMC2702532 · Brain & development · 2009 · 6 claims · 8 setups

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A novel homozygous POMT2 mutation (c.604T>G, p.F202V) causes mild congenital muscular dystrophy with normal brain MRI

skeletal genomic cos serum immunohistochemistry immunoblotting laminin
A novel recessive Nefl mutation causes a severe, early-onset axonal neuropathy.

PMID 20039262 · PMC4439312 · Annals of neurology · 2009 · 8 claims · 8 setups

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A homozygous NEFL nonsense mutation (E210X) causes a severe, early-onset recessive axonal neuropathy in four siblings of a consanguineous family

family sural nefl-null sw-13 clinical genetic immunohistochemistry
A metadata approach for clinical data management in translational genomics studies in breast cancer.

PMID 19948017 · PMC3225860 · BMC medical genomics · 2009 · 8 claims · 5 setups

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A metadata/CDE-based approach using CancerGrid's semantic web tools enables automatic integration of heterogeneous clinical datasets without loss of original detail

clinical breast metadata estrogen her2
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer.

PMID 33772001 · PMC7998036 · Nature communications · 2021 · 8 claims · 8 setups

Has reproduction · 85

AAMDC is an amplified/overexpressed oncogene in a subgroup of ER-positive breast cancers (IntClust2) associated with poor prognosis

breast luminal sum52pe t-47d immunohistochemistry fluorescence qrt-pcr
Understanding the mechanisms of drug-associated interstitial lung disease.

PMID 15340376 · PMC2750813 · British journal of cancer · 2004 · 8 claims · 7 setups

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Apoptosis of alveolar/bronchial epithelial cells via Fas-FasL and mitochondrial (cytochrome c/caspase-9) pathways is a key mechanism underlying drug-, chemotherapy-, and radiation-associated lung injury and fibrosis

bronchial lung swiss mice immunohistochemistry toxicology pulmonary
Squamous morules are functionally inert elements of premalignant endometrial neoplasia.

PMID 19180120 · PMC2633489 · Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009 · 8 claims · 5 setups

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Squamous morules are hormonally incompetent, lacking ER/PR expression and proliferative activity, unlike the glandular component

endometrial ein microdissected morule-bearing immunohistochemistry laser retrospective
A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series.

PMID 18234697 · PMC2577762 · Brain : a journal of neurology · 2008 · 8 claims · 7 setups

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Five different pathogenic GRN mutations (frameshift/premature termination) were identified in 25 affected members of a large UK FTLD cohort, with no whole-gene deletions detected

ftld grn genomic post-mortem clinical volumetric direct
p53 mutations occur in clinical, but not latent, human prostate carcinoma.

PMID 7737911 · PMC5920585 · Japanese journal of cancer research : Gann · 1995 · 5 claims · 4 setups

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p53 point mutations occur in clinical prostate cancer but not in latent (subclinical) prostate carcinoma

prostate sscp rflp direct
Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver.

PMID 10362118 · PMC2363034 · British journal of cancer · 1999 · 7 claims · 6 setups

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p73 protein is expressed (nuclear immunostaining) in a substantial subset of cholangiocellular carcinomas

cholangiocellular ccc lysates immunohistochemistry direct western
Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma.

PMID 12771989 · PMC2377153 · British journal of cancer · 2003 · 7 claims · 6 setups

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Reduced Axin expression is correlated with tumour progression of oesophageal SCC

surgical oesophageal excised clinical immunohistochemistry western northern
nm23-H1 protein expression and gene mutation in 150 patients with non-Hodgkin's lymphomas.

PMID 16891807 · PMC2729885 · Journal of Korean medical science · 2006 · 8 claims · 4 setups

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High nm23-H1 protein expression is associated with high IPI score in non-Hodgkin's lymphomas

non-hodgkin's immunohistochemistry pcr-sscp sequencing
A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC.

PMID 38157249 · PMC10781479 · Aging · 2023 · 7 claims · 8 setups

Has reproduction · 85

Consensus clustering of 74 oxidative stress-related genes identifies three distinct HNSCC molecular subgroups (Cluster1-3) with significantly different overall survival and tumor stage distribution

tcga-hnscc gse41613 gse103322 prjeb23709 bulk single-cell immunohistochemistry
Multiple molecular marker testing (p53, C-Ki-ras, c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer.

PMID 10945494 · PMC2374666 · British journal of cancer · 2000 · 6 claims · 4 setups

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Testing 3 molecular markers (c-Ki-ras, p53, c-erbB-2) together improves estimation of prognosis compared to single marker testing and defines low- and high-risk groups for treatment failure in R0-resected NSCLC.

paired frozen nsclc sscp immunohistochemistry clinical
Integrating multi-omics data reveals the antitumor role and clinical benefits of gamma-delta T cells in triple-negative breast cancer.

PMID 40197136 · PMC11974128 · BMC cancer · 2025 · 8 claims · 8 setups

Has reproduction · 59

High γδT cell infiltration is associated with favorable prognosis in TNBC but not in HR-positive or HER2-positive breast cancer

tnbc tcga-brca metabric single-cell bulk immunohistochemistry
Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?

PMID 17595663 · PMC2360307 · British journal of cancer · 2007 · 8 claims · 14 setups

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A SNP in the cytidine deaminase (CDA) gene (208G>A, haplotype *3) decreases gemcitabine clearance, increases Cmax/AUC, and increases neutropenia risk when gemcitabine is combined with platinum drugs or 5-FU

japanese paraffin-embedded tumour recombinant prospective immunohistochemistry pcr
Comprehensive analysis of a novel RNA modifications-related model in the prognostic characterization, immune landscape and drug therapy of bladder cancer.

PMID 37124622 · PMC10131083 · Frontiers in genetics · 2023 · 8 claims · 8 setups

Has reproduction · 71

Two distinct RNA modification patterns exist among BCa samples with radically varying clinical outcomes and biological characteristics

meta-geo tcga-blca bca genomics unsupervised lasso weighted

Experiments

MSI test to distinguish between HNPCC and other predisposing syndromes -- of value in tailored surveillance.

Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours.

Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1.

Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage.

A novel POMT2 mutation causes mild congenital muscular dystrophy with normal brain MRI.

A novel recessive Nefl mutation causes a severe, early-onset axonal neuropathy.

A metadata approach for clinical data management in translational genomics studies in breast cancer.

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer.

Understanding the mechanisms of drug-associated interstitial lung disease.

Squamous morules are functionally inert elements of premalignant endometrial neoplasia.

A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series.

p53 mutations occur in clinical, but not latent, human prostate carcinoma.

Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver.

Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma.

nm23-H1 protein expression and gene mutation in 150 patients with non-Hodgkin's lymphomas.

A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC.

Multiple molecular marker testing (p53, C-Ki-ras, c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer.

Integrating multi-omics data reveals the antitumor role and clinical benefits of gamma-delta T cells in triple-negative breast cancer.

Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?

Comprehensive analysis of a novel RNA modifications-related model in the prognostic characterization, immune landscape and drug therapy of bladder cancer.