Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues.

  PMID 41974725 · PMC13249863 · Nature communications · 2026 · 8 claims · 8 setups

  Full-text index only

  SARS-CoV-2 rarely infects villous and decidual placental tissues in the first trimester despite maternal infection

  villous maternal rt-qpcr fluorescence indirect

• Loss of Ezh2 promotes M2-like macrophage polarization in hepatocellular carcinoma.

  PMID 41869562 · PMC12999353 · iScience · 2026 · 8 claims · 7 setups

  Full-text index only

  Hepa1-6 conditioned media (CM) induces M2-like polarization of BMDMs in a dose-dependent manner

  bmdms rt-qpcr western flow

• SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue.

  PMID 41881972 · PMC13018599 · Nature communications · 2026 · 8 claims · 8 setups

  Full-text index only

  Adipocyte progenitors secrete SLIT3, which is cleaved into SLIT3-N and SLIT3-C fragments that independently drive angiogenesis and sympathetic innervation, respectively

  bat brown single-cell qpcr western

• Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue.

  PMID 41261284 · PMC12715258 · EMBO reports · 2025 · 8 claims · 8 setups

  Has reproduction · 78

  Imbalanced sympathetic/thermogenic activation (via UCP1 deficiency or pharmacological futile thermogenesis) causes BAT inflammation, fibrosis and degeneration

  bat wild-type brown histology qrt-pcr norepinephrine

• The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

  PMID 28346411 · PMC5699924 · Nature medicine · 2017 · 8 claims · 8 setups

  Has reproduction · 78

  12,13-diHOME is a cold-induced lipokine that stimulates BAT activity

  plasma bat serum mice lc-ms correlation 18f-fdg

• Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.

  PMID 27355630 · PMC4927094 · PloS one · 2016 · 8 claims · 8 setups

  Has reproduction · 54

  In Cstb-/- microglia, 184 genes were differentially expressed relative to control, of which 33 were identified by both microarray and RNA-seq.

  analysis microarray rna-seq quantitative

• Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.

  PMID 34811438 · PMC8608887 · Scientific reports · 2021 · 8 claims · 8 setups

  Has reproduction · 50

  Human osteoclasts differentiate on cartilage, expressing osteoclast markers, and visibly damage the cartilage surface without forming resorption pits or F-actin rings as seen on dentine.

  cd14+ osteoclasts conditioned osteoclast gag direct

• Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.

  PMID 41933175 · PMC13052164 · Nature metabolism · 2026 · 8 claims · 8 setups

  Has reproduction · 48

  Irisin modulates adipose tissue inflammation by increasing IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues, thereby improving obesity and glucose intolerance.

  4-week-old hfd-fed bat iwat aav8-mediated body intraperitoneal