Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses.

  PMID 41813846 · PMC13083880 · The EMBO journal · 2026 · 8 claims · 8 setups

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  CAPN3 promotes rapid dissociation of PRC1 complexes from chromatin in response to stress

  hepatocytes liver doxycycline-inducible capn3 chip-seq cut&tag western

• MerTK-triggered TGFβ1 autocrine signal regulates microglial response to neurodegeneration.

  PMID 41634038 · PMC12976283 · Nature communications · 2026 · 8 claims · 8 setups

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  Microglial response to pathological axonal degeneration (optic nerve injury) depends on the phagocytic receptor MerTK

  optic facs-sorted microglia co-immunostaining qpcr bulk

• TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis.

  PMID 41492090 · PMC12858408 · Nature cancer · 2026 · 7 claims · 8 setups

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  TGFβ initially induces a full, typical EMT (stress fibers, loss of epithelial markers, motility) in dormancy-competent LUAD progenitors that subsequently transitions into an atypical spheroidal mesenchymal state lacking actin stress fibers.

  h2087-lcc m802t4-lcc reconstructed immunofluorescence antibody-mediated

• Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis.

  PMID 36323713 · PMC9630272 · Nature communications · 2022 · 8 claims · 8 setups

  Has reproduction · 63

  Loss of AR in stromal Gli1-lineage cells diminishes prostate epithelial oncogenesis and tumor development in vivo

  ugm hi-myc prostate hmyctg+ genetically single-cell immunohistochemistry

• FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice.

  PMID 37226685 · PMC10331587 · EMBO molecular medicine · 2023 · 8 claims · 8 setups

  Has reproduction · 83

  ILEI protein, but not mRNA, is elevated in psoriatic skin and correlates with disease severity

  skin full-thickness normal k5-ileiind immunohistochemistry scrna-seq bulk

• miR-203 facilitates timely cell fate transitions via epigenetic modulation during early embryogenesis.

  PMID 41811946 · PMC12978216 · Science advances · 2026 · 8 claims · 8 setups

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  miR-203 is required for a timely totipotency-to-pluripotency transition during early mouse embryogenesis

  preimplantation 8-cell mice mir-203 qrt-pcr genotyping time-lapse

• VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.

  PMID 41820368 · PMC13121600 · Nature communications · 2026 · 8 claims · 8 setups

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  CBFB (CBF-β) is a synthetic lethal interactor of VHL in ccRCC cell lines

  786o ccrcc tcga genome-wide competitive immunoblot

• Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.

  PMID 41477881 · PMC12850507 · Science (New York, N.Y.) · 2026 · 8 claims · 8 setups

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  A haplotype at the 17q22 locus, tagged by the noncoding variant rs17834140-T, is a causal protective variant against CHIP and myeloid malignancies

  population hspcs cd34+cd45ra-cd90+ heterozygous gwas atac-seq crispr

• Endothelial stem cells of the retinal vasculature reside in the optic nerve.

  PMID 41577708 · PMC12830651 · Nature communications · 2026 · 8 claims · 8 setups

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  CD157+CD201+ endothelial stem cells (VESCs) reside predominantly in the optic nerve and supply endothelial cells to the retina

  cd45negcd31+ sorted retina procr[cd201]-creert2 flow colony-forming flat-mount