Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• VIST: variational inference for single cell time series.

  PMID 41535949 · PMC12892444 · Genome biology · 2026 · 8 claims · 6 setups

  Full-text index only

  VIST is a VAE-based method that decomposes single-cell gene expression into time-dependent and time-independent latent components

  toy drosophila aorta lung synthetic time-course latent

• Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson's disease.

  PMID 38566100 · PMC10985960 · Cell communication and signaling : CCS · 2024 · 8 claims · 8 setups

  Has reproduction · 55

  Microglia, endothelial cells, and pericytes exhibit the highest IFN-I activity among PD midbrain cell types, with microglia and endothelial cells showing significantly elevated high-IFN-I-scoring proportions in PD versus controls

  midbrain single microglia substantia single-cell scenic monocle

• Cell type-specific eQTL analysis of COVID-19 based on single-cell transcriptomic data.

  PMID 41064594 · PMC12501775 · NAR genomics and bioinformatics · 2025 · 8 claims · 8 setups

  Has reproduction · 51

  Single-cell eQTL analysis across eight immune cell types identified 2593 genes whose expression is significantly associated with common genetic polymorphisms, with most genes showing cell type-specific effects

  pbmcs eight pbmc monocytes scrna-seq genetic cis-eqtl

• Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations.

  PMID 41811178 · PMC12978698 · eLife · 2026 · 8 claims · 8 setups

  Full-text index only

  Cell type-specific Bayesian and co-expression networks generated from BMSC-OB scRNA-seq data in Diversity Outbred mice can prioritize and contextualize genes underlying human BMD GWAS associations

  bmsc-ob genes mesenchymal gtex scrna-seq cellect iterativewgcna

• scDEBGCL: a deep embedding approach based on bipartite graph contrastive learning for single-cell RNA-seq data.

  PMID 41981652 · PMC13188691 · BMC biology · 2026 · 7 claims · 3 setups

  Full-text index only

  scDEBGCL is a deep embedding method for scRNA-seq data based on bipartite graph contrastive learning, integrating contrastive learning, graph reconstruction, and ZINB-based data reconstruction losses.

  nine yan dpt scrna-seq trajectory

• GRNFormer: accurate gene regulatory network inference using graph transformer.

  PMID 41883144 · PMC13069479 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 8 setups

  Full-text index only

  GRNFormer is a generalizable graph transformer framework for GRN inference from single-cell or bulk transcriptomics data across species, cell types, and platforms without cell-type annotations or prior regulatory information

  hematopoietic embryonic dendritic hepatocytes scrna-seq chip-seq string

• Data driven network inference and longitudinal transcriptomics unveil dynamic regulation in Chronic Lymphocytic Leukaemia models.

  PMID 41540084 · PMC12894745 · NPJ systems biology and applications · 2026 · 8 claims · 8 setups

  Full-text index only

  The presence of immune cells in the environment significantly alters CLL cell activation

  autologous monoculture non-adherent pbmc bulk flow deconvolution

• A differential single-cell transcriptome atlas of left-sided and right-sided colorectal cancer.

  PMID 41844817 · PMC13111741 · Discover oncology · 2026 · 8 claims · 8 setups

  Full-text index only

  MTRNR2L8 is markedly upregulated in RCRC tumor cells and is associated with poorer patient survival

  crc epithelial rcrc tcga-read scrna-seq copy gene

• CaHoT-GRN: context-aware high-order topology learning for robust single-cell gene regulatory network inference.

  PMID 42059479 · PMC13130071 · Briefings in bioinformatics · 2026 · 7 claims · 5 setups

  Full-text index only

  CaHoT-GRN integrates pretrained biological language model embeddings (DNABERT for DNA, ESM for protein) with scRNA-seq expression data to improve GRN inference

  embryonic gene dataset-specific same scrna-seq-based sequence protein-protein

• Identification of Cell Subpopulation-Specific Driver Genes Reveals Ideal Candidates for Renal Cell Carcinoma Immunotherapy.

  PMID 42074110 · PMC13115843 · International journal of molecular sciences · 2026 · 8 claims · 8 setups

  Full-text index only

  25 immune-related candidate driver genes were identified from tumor, myeloid, and lymphoid cell gene regulatory networks (GRNs) using SCENIC and topological Q statistics.

  kidney lymphoid rcc tcga-kirc single-cell scenic genome-wide

• AutoGERN: single-cell RNA-seq gene regulatory network inference via explicit link modeling and adaptive architectures.

  PMID 41871930 · PMC13064981 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 3 setups

  Full-text index only

  AutoGERN explicitly models regulatory information in the message-passing space via learned link (edge) embeddings, which are scored by a lightweight MLP to infer TF–target interactions.

  seven same scrna-seq-based chip-seq cold-start

• Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal.

  PMID 41746282 · PMC12998610 · Bioinformatics (Oxford, England) · 2026 · 8 claims · 5 setups

  Full-text index only

  dominoSignal extends the Domino algorithm to enable statistical testing of differential cell-cell signaling between experimental conditions.

  single-cell simulated pdac per-sample single-cell simulation cell-cell

• Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations.

  PMID 19851457 · PMC2760143 · PLoS pathogens · 2009 · 8 claims · 4 setups

  Full-text index only

  Genetically distinct RV clades of the same G/P-type (G3P[8]) can co-circulate within a single epidemic season and cause disease

  g3p[8] rv-positive concatenated deduced rt-pcr pcr-elisa phylogenetic

• S3RL: Enhancing Spatial Single-Cell Transcriptomics With Separable Representation Learning.

  PMID 41556263 · PMC13042551 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

  Full-text index only

  S3RL is a separable representation learning framework that denoises sparse spatial transcriptomic data and enhances biologically relevant signals by integrating gene expression, spatial coordinates, and histological image features.

  dorsolateral dlpfc nanostring spatial cell-type multi-platform

• Bridging cancer cell-intrinsic driver genes and -extrinsic cell-cell communication with Driver2Comm.

  PMID 41701761 · PMC12928580 · PLoS computational biology · 2026 · 8 claims · 5 setups

  Full-text index only

  Driver2Comm is a computational framework that identifies intrinsic-extrinsic (IE) pathways functionally connecting cancer cell driver genes with their associated CCC signatures in the TME using single-cell transcriptomics data.

  pdac genes tcga single-cell copy fisher's

• Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation.

  PMID 41851525 · PMC13132723 · Nature immunology · 2026 · 8 claims · 8 setups

  Full-text index only

  Microglia repopulate rapidly and exclusively cell-autonomously from surviving microglia after CSF-1R inhibitor (BLZ945) depletion.

  brain cerebral cd11b+cd45int-hi leptomeninges flow confocal single-cell

• Therapeutic Targeting of Oxidative Phosphorylation in Microsatellite Instability-High Gastric Cancer.

  PMID 42038020 · PMC13104725 · Journal of Cancer · 2026 · 7 claims · 8 setups

  Full-text index only

  MSI gastric cancer samples show significantly greater T cell infiltration and a lower proportion of epithelial cells compared to GS samples

  gastric epithelial stomach nod-scid single-cell cnv differential

• PSGRN: Gene regulatory network inference from single-cell perturbational data through self-training with synthetic gold standards.

  PMID 42054465 · PMC13127566 · Science advances · 2026 · 8 claims · 4 setups

  Full-text index only

  PSGRN infers GRNs by generating pseudoannotations from gene-gene correlations and iteratively refining them via a self-training classifier using pre/post-intervention expression features.

  k562 rpe1 processed single-cell computational biological

• IMIREG: a lineage-resolved regulon signature unveiling immune engagement archetypes and predicting immunotherapy response across diverse cancers.

  PMID 42092126 · PMC13234301 · NPJ precision oncology · 2026 · 8 claims · 8 setups

  Full-text index only

  IMIREG, a 14-regulon transcriptional signature, robustly predicts clinical benefit from ICB across 50 immunotherapy cohorts (52 treatment arms) spanning 16 cancer types with mean AUROC = 0.71

  imvigor210 matched gtex healthy bulk scrna-seq pathway

• huSA: a comprehensive database for multi-dimensional resolution of bulk, single cell and spatial transcription profiles in skin diseases.

  PMID 41719583 · PMC12923168 · Database : the journal of biological databases and curation · 2026 · 7 claims · 8 setups

  Has reproduction · 50

  huSA is a comprehensive, publicly accessible database integrating bulk RNA-seq, scRNA-seq, and spatial transcriptomics data across 17 skin diseases and 63 independent datasets

  skin scrna-seq scrna-seq transcription cell-cell