Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets.

  PMID 41563441 · PMC13007207 · Diabetes · 2026 · 8 claims · 7 setups

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  5′ single-cell library preparation protocols outperform 3′ protocols for transcript identification and read length

  lines pancreatic spleen dtc single-cell bulk ngs

• Directing stem cell differentiation by chromatin state approximation.

  PMID 41734818 · PMC12956330 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  Greedy selection of culture conditions by chromatin (ATAC-seq) distance to target is a viable optimisation strategy for differentiation protocols

  cd34+ cd34+-derived erythroid bone atac-seq flow rt-qpcr

• Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver.

  PMID 40345590 · PMC12180993 · The Journal of biological chemistry · 2025 · 8 claims · 9 setups

  Has reproduction · 87

  TXNIP Cysteine 247 is required for high-fat diet-induced hepatic and whole-body insulin resistance in mice

  txnip plasma 8-week liver insulin lipidomics hyperinsulinemic-euglycemic

• Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects.

  PMID 41986506 · PMC13226668 · The EMBO journal · 2026 · 8 claims · 6 setups

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  Single-cell transcriptome profiling of 245,878 islet cells from 48 donors (ND/PD/T2D) identifies 14 distinct, robust islet cell types detected in every donor

  pancreatic aggregated endoc-βh3 subset droplet-based pseudobulk unsupervised

• Alternative polyadenylation mediated the downregulation of lysophosphatidylglycerol acyltransferase 1 in metabolic dysfunction-associated steatotic liver disease.

  PMID 41507908 · PMC12879358 · Lipids in health and disease · 2026 · 8 claims · 8 setups

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  Early hepatocyte-specific APA remodeling, characterized by 3' UTR lengthening of metabolism-related genes (especially LPGAT1), occurs in MASLD and is established before fibrosis progression

  liver hepg2 293t serum bulk single-cell oil

• Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.

  PMID 41648986 · PMC12918713 · ACS nano · 2026 · 7 claims · 8 setups

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  Maternal PM2.5 exposure induces insulin resistance in middle-aged male (but not female) offspring despite normal body weight/obesity status

  pregnant iwat adsc whole-body body histology

• Stimulation to secrete insulin induces pancreatic β-cell dysfunction through Tfe3 activation.

  PMID 41940345 · PMC13049674 · iScience · 2026 · 8 claims · 8 setups

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  Continuous glucose supplementation in mice induces Tfe3 nuclear accumulation in islet β-cells, associated with Mafa downregulation and impaired glucose tolerance

  c57bl pancreas min6 intraperitoneal immunofluorescence insulin

• Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys.

  PMID 41042069 · PMC12686577 · Aging cell · 2025 · 8 claims · 8 setups

  Has reproduction · 66

  At baseline, SAT and VAT transcriptomes are highly similar, with only ~1% of genes (30 genes, adjusted p<0.05) differentially expressed between depots in Controls

  subcutaneous sat rhesus bulk gsea xcell

• TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

  PMID 42020373 · PMC13102947 · Nature communications · 2026 · 8 claims · 8 setups

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  TBL/R1 are crucial regulators of β-cell identity and determinants of diabetes development and progression

  pancreatic fed paraffin-embedded pancreas qpcr blood oral

• Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity.

  PMID 41779769 · PMC12978566 · PLoS biology · 2026 · 8 claims · 8 setups

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  Gpc3 is an obesity-responsive gene exhibiting reciprocal expression patterns between subcutaneous and visceral adipose depots in mice and humans

  paired iwat asat subcutaneous dia single-cell qpcr

• Novel insights into adipogenesis from omics data.

  PMID 19689276 · PMC2765082 · Current medicinal chemistry · 2009 · 8 claims · 8 setups

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  Pparg and Cebpa are the two master transcriptional regulators governing adipogenesis

  3t3-l1 embryonic multipotent nih-3t3 microarray gel non-gel-based

• Multimodal single-cell protein and RNA profiling unveils dysregulated immature neutrophil dynamics in gestational diabetes mellitus.

  PMID 41501166 · PMC12936121 · Communications biology · 2026 · 8 claims · 6 setups

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  A combination of CD10−CD49d+Igκ+ surface markers identifies an immature low-density neutrophil (LDN) subset that is distinct from CD10+ mature high-density neutrophils (HDNs)

  peripheral facs-sorted decidua pregnant infinityflow conventional may-grünwald

• An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines.

  PMID 41997152 · PMC13163220 · Stem cell reports · 2026 · 8 claims · 8 setups

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  Shortening the S4 pancreatic progenitor stage duration enhances subsequent S5 endocrine progenitor (EP) differentiation efficiency

  hs980 hpsc-derived eight sc-islets flow static dynamic

• Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution.

  PMID 33440156 · PMC8240962 · Cell reports · 2021 · 8 claims · 8 setups

  Has reproduction

  Endogenous fatty acid synthesis (DNL), regulated by ChREBP, is the central driver of BAT whitening/involution at thermoneutrality.

  bat fatty lipidomics qpcr