Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen.

  PMID 41634022 · PMC12966279 · Nature communications · 2026 · 8 claims · 8 setups

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  Dual RNA-Seq of L. interrogans-infected hamsters reveals the in vivo host-pathogen transcriptomic landscape during infection

  golden interrogans hamster epithelial dual rna-seq qpcr

• Dynamic changes of the immune microenvironment in ovarian cancer following neoadjuvant chemotherapy.

  PMID 41872134 · PMC13039919 · Cell death discovery · 2026 · 8 claims · 8 setups

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  Prostaglandin-mediated immunosuppressive microenvironment formation is a critical contributor to chemotherapy resistance following cisplatin treatment

  high-grade hgsoc bone bmdms scrna-seq cell-cell tensor

• Stimulation to secrete insulin induces pancreatic β-cell dysfunction through Tfe3 activation.

  PMID 41940345 · PMC13049674 · iScience · 2026 · 8 claims · 8 setups

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  Continuous glucose supplementation in mice induces Tfe3 nuclear accumulation in islet β-cells, associated with Mafa downregulation and impaired glucose tolerance

  c57bl pancreas min6 intraperitoneal immunofluorescence insulin

• HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.

  PMID 41807716 · PMC13096512 · Scientific reports · 2026 · 8 claims · 8 setups

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  OS activity is significantly elevated in AD and shows pronounced heterogeneity across brain cell types

  entorhinal brain middle c57bl scrna-seq bulk animal

• Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.

  PMID 41673768 · PMC12998334 · Journal of experimental & clinical cancer research : CR · 2026 · 6 claims · 8 setups

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  Organoids derived from malignant effusions of PDAC patients reproducibly generate peritoneal metastases after orthotopic implantation into the pancreas of immunodeficient mice

  pdac organoids frozen pdox orthotopic single-nucleus single-cell

• Tissue-resident macrophage and dendritic cells drive type I IFN immunity to enteroviruses in the liver.

  PMID 41592119 · PMC12858076 · PLoS pathogens · 2026 · 8 claims · 6 setups

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  Type I IFN signaling (Ifnar1), but not type III IFN signaling (Ifnlr1), is essential for survival and for limiting viral replication in the liver during echovirus infection

  neonatal liver survival viral h&e

• Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissue.

  PMID 41689157 · PMC13005559 · Cardio-oncology (London, England) · 2026 · 8 claims · 7 setups

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  Chronic oxaliplatin treatment causes direct cardiotoxicity in mice, evidenced by ECG, histology, and RNA-seq changes.

  c57bl heart ecg histology heart

• Engineering NK and T cells with metabolite-sensing receptors to target solid tumors.

  PMID 41872506 · PMC13132725 · Nature immunology · 2026 · 8 claims · 8 setups

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  GPR183, GPR84, GPR34 and GPR18 were identified as top enhancers of NK cell tumor infiltration and chemotaxis to breast and ovarian cancer via CRISPRa screens

  nk-92 reporter tumor crispra large-scale transwell