Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome.

  PMID 8245784 · PMC2191306 · The Journal of experimental medicine · 1993 · 8 claims · 6 setups

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  All 30 SMS patient sera selectively recognize GAD-65, but not GAD-67, when tested by Western blotting on denatured GAD.

  brain bacterial triton cho western immunoprecipitation immunocytochemistry

• Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response.

  PMID 41728950 · PMC12926921 · Nucleic acids research · 2026 · 5 claims · 8 setups

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  CRISPR-dCas9-based screens exhibit widespread promoter specificity, with untargeted promoters often showing compensatory upregulation to maintain overall gene expression

  mcf-7 rpe1 mcf-7-dcas9 tissue-wide isoform-specific reanalysis qrt-pcr

• Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism.

  PMID 36660474 · PMC9843443 · iScience · 2023 · 8 claims · 8 setups

  Has reproduction · 71

  ER stress reduces the complexity and sialylation of trophoblast protein N-glycosylation

  bewo eif2s1 umbilical placenta maldi-tof western rt-pcr

• Colocalization of increased transforming growth factor-beta-induced protein (TGFBIp) and Clusterin in Fuchs endothelial corneal dystrophy.

  PMID 19011008 · PMC2719557 · Investigative ophthalmology & visual science · 2009 · 6 claims · 5 setups

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  TGFBIp (multiple molecular weight forms) is significantly overexpressed in FECD HCEC-DM complex compared to normal endothelium

  pooled hcec-dm corneal 2-d western real-time

• Decoding unchanged transcriptome of Alzheimer's disease reveals an NCAM1 mRNA switch as a potential biomarker.

  PMID 42006342 · PMC13090632 · iScience · 2026 · 8 claims · 7 setups

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  Most genes are gene-level non-differentially expressed (nDEGs) in AD but nDEGs are strongly associated with neuronal function pathways

  hippocampus brain bulk alternative isoform

• Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein.

  PMID 16507314 · PMC7111751 · Virology · 2006 · 7 claims · 8 setups

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  Expression of SARS-CoV E protein in mammalian cells alters membrane permeability

  hela sf9 hygromycin site-directed subcellular

• Transcriptional readthrough precedes alternative splicing programs triggered in CML cells by imatinib.

  PMID 41860998 · PMC13004010 · Science advances · 2026 · 8 claims · 6 setups

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  Imatinib treatment induces transcriptional readthrough in K562 CML cells within 1 hour, before detectable gene expression or alternative splicing changes

  k562 imatinib-resistant long-read short-read rt-qpcr

• Manipulation of Alternative Splicing of IKZF1 Elicits Distinct Gene Regulatory Responses in T Cells.

  PMID 41677588 · PMC12896614 · Cells · 2026 · 8 claims · 6 setups

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  Alternative splicing of IKZF1 in human T cells strongly influences gene expression, chromatin accessibility, and protein production.

  jurkat genomic cd4+ rna-seq atac-seq immunoblotting

• Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome.

  PMID 41956098 · PMC7619149 · Immunity · 2026 · 8 claims · 8 setups

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  Reduced NMD activity (lower NMD score) predicts improved CPI response across >1,000 patients, independent of TMB or tumor type

  tcga a375 reporter patient-derived multi-omics crispr-cas9 sirna

• Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma.

  PMID 39057099 · PMC11276454 · Current issues in molecular biology · 2024 · 8 claims · 8 setups

  Has reproduction · 59

  PTBP1 is significantly upregulated across multiple cancer types including LUAD, and higher PTBP1 levels are associated with worse LUAD patient survival

  cancer luad fibroblast a549 pan-cancer differential replicative

• GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.

  PMID 40204713 · PMC11982250 · Nature communications · 2025 · 8 claims · 7 setups

  Has reproduction · 91

  GRAMD1B is increased in excitatory neurons of human neural organoids (HNOs) carrying the MAPT R406W mutation

  neural hno single-cell immunofluorescence western

• Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling.

  PMID 18157127 · PMC2397541 · Nature genetics · 2008 · 8 claims · 8 setups

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  Homozygous truncating mutations in PCNT cause Seckel syndrome

  consanguineous genomic lymphoblastoid lcls snp-microarray sanger immunofluorescence

• Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.

  PMID 18922159 · PMC2614521 · Breast cancer research : BCR · 2008 · 8 claims · 5 setups

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  PGRMC1 protein spots are differentially abundant between ER-negative and ER-positive breast tumors, with two of three spots more abundant in ER-negative tumors

  sections pooled mcf7 paraffin-embedded 2d-page shrimp viability

• Modeling splicing outcome by combining 5'ss strength and splicing regulatory elements.

  PMID 35947702 · PMC9410876 · Nucleic acids research · 2022 · 7 claims · 8 setups

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  In silico designed sequences with a priori prescribed HEXplorer splicing regulatory properties can be concatenated to arbitrary length without changing their regulatory properties

  hela proteins fibroblasts cardiovascular massively rt-pcr quantitative

• SOX2 phosphorylation during mitosis limits genomic damage.

  PMID 41213799 · PMC12863253 · Genes & development · 2026 · 8 claims · 8 setups

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  SOX2 (but not SOX9) remains dynamically bound to mitotic chromatin throughout all mitotic stages in neural stem cells

  sox2-halo nscs flag-wt-sox2 live-cell immunocytochemistry frap

• Flamenco plasticity tunes somatic piRNAs and rewires isoforms, with implications for heritable transposon spread.

  PMID 42009568 · PMC13097621 · Life science alliance · 2026 · 8 claims · 8 setups

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  Springer drives host gene expression changes via promoter-proximal intronic insertions at an AT-rich motif, with its 5′ LTR initiating transcription that splices into downstream host exons to create hybrid isoforms without adding coding sequence

  drosophila pacbio long-read plasmid

• Pharmaco-proteomic study of hydroxyurea-induced modifications in the sickle red blood cell membrane proteome.

  PMID 18849548 · PMC4260454 · Experimental biology and medicine (Maywood, N.J.) · 2008 · 6 claims · 6 setups

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  50 μM HU treatment of SS RBC membranes causes statistically significant changes in a discrete set of membrane proteins, distinct from HbF induction.

  sickle rbc excised 2d-dige tandem immunoblot

• Nucleotide oligomerization domain-2 interacts with 2'-5'-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells.

  PMID 19853919 · PMC2787966 · Molecular immunology · 2009 · 7 claims · 6 setups

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  OAS2 is identified as a novel NOD2-binding partner in THP-1 cells by tandem affinity purification and mass spectrometry

  thp-1 hek293 tandem co-immunoprecipitation oas2