Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 77
Hepatocyte dedifferentiation in 2D culture reveals extensive transcriptomic and proteomic rewiring.
PMID 41111196 · PMC12506984 · Hepatology communications · 2025 · 8 claims · 4 setups
24 hours of 2D culturing changes >10,000 genes and ~3000 proteins in primary hepatocytes compared with freshly isolated cells, reflecting major transcriptomic and proteomic rewiring.
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Has reproduction · 100
The liver as an immunological barrier redefined by single-cell analysis.
PMID 32176810 · PMC7218664 · Immunology · 2020 · 8 claims · 8 setups
Single-cell RNA-seq enables unbiased characterization of liver cell states, developmental trajectories and rare immune populations that bulk averaging obscures, redefining liver cell-type mapping.
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Full-text index only
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4).
PMID 9989976 · PMC2192941 · The Journal of experimental medicine · 1999 · 8 claims · 8 setups
The Lps locus was fine-mapped to a 0.9-cM interval spanning a 1.7-Mb genomic contig on mouse chromosome 4.
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Has reproduction · 67
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
PMID 28930663 · PMC5719893 · Immunity · 2017 · 8 claims · 8 setups
A common APOE-dependent microglial molecular signature (MGnD) — loss of homeostatic genes plus induction of inflammatory genes with Apoe among the most upregulated — occurs in ALS, MS and AD mouse models and around neuritic Aβ-plaques in human AD brain.