Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Prediction of specificity-determining residues for small-molecule kinase inhibitors.

  PMID 19032760 · PMC2655090 · BMC bioinformatics · 2008 · 8 claims · 5 setups

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  S-Filter is a novel method combining sequence and structural information (within PFAAT) to predict specificity-determining residues and selectivity profiles for small-molecule kinase inhibitors

  panel kinase-inhibitor sequence erk2 caliper radiometric solvent

• Sequence-non-specific effects of RNA interference triggers and microRNA regulators.

  PMID 19843612 · PMC2800214 · Nucleic acids research · 2010 · 8 claims · 7 setups

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  Reagents of RNAi and miRNA technologies often trigger unintended sequence-non-specific immune responses in addition to intended sequence-specific silencing

  recombinant t98g hek293 hela kinase pkr microarray

• Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA.

  PMID 19740104 · PMC3107988 · The FEBS journal · 2009 · 8 claims · 4 setups

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  Human topoisomerase I (topo70) does not dimerize either free in solution or when covalently bound to DNA, ruling out dimerization as the source of a second DNA binding site

  gst-topo70 topo70 32p-labeled 3h-labeled gst gel 32p-labeled