Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 9

System / cell line: degs ✕ Assay: lentiviral ✕ Clear

Insights from pooled CRISPRi single-cell screens in K562 cells reveal gene functions, regulatory networks, and highlight opportunities and limitations.

PMID 41826830 · PMC13097927 · BMC genomics · 2026 · 7 claims · 7 setups

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A modified CROP-seq-CRISPRi protocol allows direct capture of sgRNAs from the cDNA library without a separate enrichment step, improving sgRNA assignment per cell

k562 lentiviral pooled plasmid amplicon
Integrative multi-omics analysis identifies C-type lectin CNVs as functional targets for breeding mastitis-resistant dairy goats.

PMID 41935313 · PMC13188593 · Animal microbiome · 2026 · 8 claims · 8 setups

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Genome-wide CNV scanning of dairy vs non-dairy goats identified 62,860 CNVs, with 115 under strong selection (top 1% Fst/Vst).

goat gmecs lps-induced whole-genome immunofluorescence lentiviral
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.

PMID 42032432 · PMC13156037 · Nature neuroscience · 2026 · 6 claims · 6 setups

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Transcriptomic convergence following NDD gene knockout is highly cell-type-specific and strongest in mature glutamatergic neurons (iGLUTs)

hipsc-derived gwas computational zebrafish single-cell immunofluorescence magma
Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia.

PMID 41270153 · PMC7618455 · Cancer research · 2026 · 8 claims · 8 setups

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ReSisTrace single-cell lineage tracing identifies pre-resistant and pre-sensitive cell states to FLT3 inhibitors midostaurin and quizartinib in FLT3-ITD-positive MOLM-13 AML cells before treatment

molm-13 aml-pdx1 single-cell lineage gene
Single-immunocyte transcriptomics reveal the role of natural killer cell-dependent exogenous antigen presentation in ankylosing spondylitis severity.

PMID 41593306 · PMC12868835 · Experimental & molecular medicine · 2026 · 8 claims · 8 setups

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Innate antibacterial defense functions are generally enhanced in most cell types at AS onset and are negatively associated with AS severity

pbmcs gwas pbmc-derived cd4+ single-cell bulk mendelian
Autocrine SFRP2 (secreted frizzled related protein 2) enhances lung myofibroblast fibrogenic activity by suppressing PINK1-mediated mitophagy initiation.

PMID 41789512 · PMC13185440 · Autophagy · 2026 · 7 claims · 8 setups

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SFRP2 is specifically highly expressed in myofibroblasts derived from fibrotic (IPF/BLM/TGFB1-induced) lung tissue

lung pmlfs mrc5 single-cell bulk histology
DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.

PMID 41612476 · PMC12930642 · Cell communication and signaling : CCS · 2026 · 8 claims · 8 setups

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DHODH is markedly overexpressed in malignant prostate epithelial cells and abundant in tumors

tcga-prad gse141445 22rv1 bulk single-cell lentiviral
Hypoxia-Induced Osteopontin-Positive Glioma-Associated Macrophages Facilitate Glioma Mesenchymal Transition via NF-κB Pathway Activation.

PMID 41625475 · PMC12857759 · Cancer communications (London, England) · 2026 · 6 claims · 8 setups

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A subset of GAMs with elevated OPN expression accumulates in response to hypoxic stimulation

thp-1 glioma orthotopic gbm bulk single-cell spatial
Reduced cartilage matrix stiffness in temporomandibular joint osteoarthritis impairs the functions of superficial zone chondrocytes via downregulation of CREB5-PLPP3 signaling.

PMID 41870835 · PMC13009359 · Molecular biomedicine · 2026 · 7 claims · 8 setups

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ECM stiffness (Young's modulus) is reduced in the superficial zone of condylar cartilage in TMJOA patients and in a rat UAC-induced TMJOA model

condylar szc tmjoa nanoindentation single-cell bulk

Experiments

Insights from pooled CRISPRi single-cell screens in K562 cells reveal gene functions, regulatory networks, and highlight opportunities and limitations.

Integrative multi-omics analysis identifies C-type lectin CNVs as functional targets for breeding mastitis-resistant dairy goats.

Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.

Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia.

Single-immunocyte transcriptomics reveal the role of natural killer cell-dependent exogenous antigen presentation in ankylosing spondylitis severity.

Autocrine SFRP2 (secreted frizzled related protein 2) enhances lung myofibroblast fibrogenic activity by suppressing PINK1-mediated mitophagy initiation.

DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.

Hypoxia-Induced Osteopontin-Positive Glioma-Associated Macrophages Facilitate Glioma Mesenchymal Transition via NF-κB Pathway Activation.

Reduced cartilage matrix stiffness in temporomandibular joint osteoarthritis impairs the functions of superficial zone chondrocytes via downregulation of CREB5-PLPP3 signaling.