Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Proteomic solutions for analytical challenges associated with alcohol research.
PMID 23584870 · PMC3860482 · Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2008 · 7 claims · 4 setups
Protein-level meta-analyses analogous to the transcriptome meta-analysis by Mulligan et al. (2006) are not yet possible because proteins lack a uniform sample preparation/analysis method and span up to 8 orders of magnitude in abundance.
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Glycomics and disease markers.
PMID 19775929 · PMC2788081 · Current opinion in chemical biology · 2009 · 8 claims · 7 setups
Over 70% of all human proteins are glycosylated
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Proteomics in alcohol research.
PMID 12875051 · PMC6683837 · Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2002 · 7 claims · 8 setups
The proteome is larger and more complex than the genome due to differential splicing, post-translational modifications (PTMs), and protein-protein interactions.
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Topology of molecular machines of the endoplasmic reticulum: a compilation of proteomics and cytological data.
PMID 18172663 · PMC2228376 · Histochemistry and cell biology · 2008 · 8 claims · 8 setups
Proteomics studies of ER subcompartments provide a protein dictionary revealing that specific molecular machines localize to specific ER subdomains
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Proteomic approaches for studying alcoholism and alcohol-induced organ damage.
PMID 23584750 · PMC3860448 · Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2008 · 8 claims · 7 setups
Chronic alcohol abuse produces persistent changes in brain function (tolerance, dependence, craving) likely resulting from alterations in gene and protein expression
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Lipids join the post-genomic era.
PMID 17076911 · PMC1794566 · Genome biology · 2006 · 8 claims · 8 setups
Infrared-laser MALDI-MS can image biological tissue while avoiding the matrix-preparation artifacts of UV-laser MALDI
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Determination of glycosylation sites and site-specific heterogeneity in glycoproteins.
PMID 19700364 · PMC2749913 · Current opinion in chemical biology · 2009 · 8 claims · 8 setups
Mass spectrometry has emerged as the premier tool for structural determination of oligosaccharides/glycans and glycopeptides