Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• MECOM Function Is Critical for AR-Driven Treatment-Resistant Prostate Cancer.

  PMID 41529070 · PMC13136877 · Cancer research · 2026 · 7 claims · 8 setups

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  EVI1, encoded by MECOM, is an AR-recruited coactivator of noncanonical AR signaling in prostate cancer.

  lrex lucap167 prostate live-cell spheroid patient-derived

• Glioblastoma invasion into different organoid hosts reveals cell-intrinsic and proliferative migratory programs.

  PMID 41959666 · PMC13059114 · iScience · 2026 · 8 claims · 8 setups

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  GB cells invade both neural and endodermal organoid hosts (lineage-independent), whereas non-malignant neural progenitor cells show markedly reduced infiltration

  gbm1 gfp-gbm1 facs-sorted post-invasion image-based immunofluorescence single-cell

• Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation.

  PMID 30561326 · PMC6307859 · eLife · 2018 · 7 claims · 8 setups

  Has reproduction · 50

  Yap1 knockout (KO) ESCs undergo massive, caspase-dependent cell death upon exiting self-renewal (LIF withdrawal), while self-renewing KO cells are unaffected.

  cj7 yap1 ldh live-cell flow

• Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.

  PMID 41931622 · PMC13048245 · Science advances · 2026 · 7 claims · 8 setups

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  Brain-specific (neural crest-derived, NC-SMC) but not peripheral (LPM-SMC/PM-SMC) iPSC-derived VSMCs are selectively vulnerable to CADASIL NOTCH3 variants

  ipsc-derived ivsmcs immunofluorescence wound collagen

• In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogen.

  PMID 41634022 · PMC12966279 · Nature communications · 2026 · 8 claims · 8 setups

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  Dual RNA-Seq of L. interrogans-infected hamsters reveals the in vivo host-pathogen transcriptomic landscape during infection

  golden interrogans hamster epithelial dual rna-seq qpcr

• Temporal dynamics of collateral RNA cleavage by LbuCas13a in human cells.

  PMID 41554880 · PMC12901986 · Communications biology · 2026 · 8 claims · 8 setups

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  LbuCas13a delivered as ribonucleoprotein (RNP) exhibits strong collateral RNA cleavage in human cells, independent of cell line, and targeting both exogenous and endogenous transcripts

  hap1 recombinant hap1-egfp lbucas13a bioanalyzer rnasealert rt-qpcr

• CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2(+) endothelial cells.

  PMID 41887221 · PMC13130657 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  CAR-M2 macrophages (anti-FAP CAR + IL-4-secreting, 4-1BB/CD3ζ costimulatory domains) specifically target and phagocytose FAP+ fibroblasts

  kidney car-m2 macrophages uuo scrna-seq histology live-cell

• The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2.

  PMID 36627412 · PMC9832098 · Cellular and molecular life sciences : CMLS · 2023 · 8 claims · 8 setups

  Has reproduction · 59

  p27 restricts residual CDK activity after mitogen withdrawal to antagonize cell cycling, but is not essential for cell cycle exit per se

  sez-derived computational nsc npc atac-seq bulk lisa