Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Allele-specific immune gene quantification and expression analysis in single-cell RNA-seq data.

  PMID 41229397 · PMC12604667 · NAR genomics and bioinformatics · 2025 · 8 claims · 4 setups

  Has reproduction · 75

  scIGD is a Snakemake workflow that automates HLA allele-typing and allele-specific expression quantification from scRNA-seq data

  aida merkel-cell 20k myeloma scrna-seq

• Aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in breast cancer.

  PMID 41719331 · PMC12933083 · Proceedings of the National Academy of Sciences of the United States of America · 2026 · 8 claims · 8 setups

  Full-text index only

  Age at NMU exposure critically influences tumor incidence, mutational burden, molecular subtype, and the tumor immune microenvironment

  virgin mammary tcga-brca carcinogen-induced immunofluorescence bulk

• Critical role for a high-plasticity cell state in lung cancer.

  PMID 41565826 · PMC12960256 · Nature · 2026 · 8 claims · 8 setups

  Full-text index only

  The HPCS is a transcriptionally distinct cancer cell state that functions as a hub for reciprocal transitions between other cancer cell states

  autochthonous kpfrt gfp+ sorted single-cell flow immunofluorescence

• Immune profiling in a living human recipient of a gene-edited pig kidney.

  PMID 41507576 · PMC12823403 · Nature medicine · 2026 · 8 claims · 8 setups

  Full-text index only

  Xenograft experienced early T cell-mediated rejection (Banff grade 2A) within 1 week post-transplant despite profound circulating T cell depletion, likely driven by subtherapeutic immunosuppression and residual CD8+ T cells in lymph nodes.

  xenotransplant recipient kidney integrative single-cell flow

• Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance.

  PMID 41776501 · PMC13162433 · Molecular cancer · 2026 · 8 claims · 6 setups

  Full-text index only

  MeRLin, a single-vector high-complexity lineage tracing platform integrating cellular barcoding, scRNA-seq, RNA-FISH, and computational analysis, was developed to track clonal and transcriptional dynamics in a melanoma PDX model

  wm4237-1 nsg bulk scrna-seq clonal

• Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy.

  PMID 33723257 · PMC7961017 · Nature communications · 2021 · 7 claims · 7 setups

  Has reproduction · 70

  Proportions of activated and proliferating CD8+ T cells (cluster C16/activated EM) are significantly higher in responders before and during therapy

  pbmc cd3+cd8+ pbmc-derived metastatic high-dimensional single-cell polychromatic

• A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

  PMID 41128661 · PMC12877754 · Cancer discovery · 2026 · 8 claims · 8 setups

  Full-text index only

  RMC-9945 exerts durable antitumor activity in early-stage liver metastasis but has diminished therapeutic effect in advanced metastatic disease

  aktp colorectal drug single-cell rnascope

• Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis.

  PMID 41778850 · PMC7619144 · Cancer discovery · 2026 · 7 claims · 8 setups

  Full-text index only

  AT2 cells and surfactant lipids (e.g., PC, PE, PI, PG) are enriched in the vicinity of breast cancer lung metastases in both patients and mice

  postmortem lungs lung at2 immunohistochemistry maldi-msi longitudinal