Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma.

  PMID 41923630 · PMC13130666 · Cell reports. Medicine · 2026 · 8 claims · 4 setups

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  A malignant cell subset expressing IFN-response and MHC-II genes (IFN/MHC-II) increases in proportion after pembrolizumab treatment and is associated with response

  hnscc ffpe syngeneic independent single-cell multiplexed tumor

• A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells.

  PMID 41484771 · PMC12882460 · Molecular cancer · 2026 · 7 claims · 5 setups

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  Integration of pan-cancer scRNA-seq data yields a comprehensive single-cell atlas of 157,025 high-quality DNT cells across 23 cancer types.

  tumor dnt ffpe mc38 scrna-seq tcr multiplex

• Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice.

  PMID 41922840 · PMC13171603 · Nature microbiology · 2026 · 8 claims · 7 setups

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  Inflammatory macrophages accumulate in joint-associated tissue during the chronic stage of CHIKV infection and show an activated, pro-inflammatory, MHC-II+ transcriptional programme

  ankle ipsilateral computational pfa-fixed rt-qpcr single-cell gene

• Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells.

  PMID 42008567 · PMC13128127 · PLoS pathogens · 2026 · 9 claims · 9 setups

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  Expansion of endogenous MCMV-specific CD8 T cells is delayed in early life due to a low precursor frequency of peripheral αβ T cells

  peripheral spleen polyclonal neonatal pmhc-i mhc-ii flow

• MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.

  PMID 41759510 · PMC7618887 · Immunity · 2026 · 8 claims · 8 setups

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  MafB is required for full differentiation of bone-marrow-derived macrophages (BMDMs) in vitro and for development of most RTMs in vivo

  bmdms peritoneal rtms irradiated bulk hashtag-barcoded intracellular

• Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

  PMID 41810957 · PMC13059739 · mBio · 2026 · 8 claims · 8 setups

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  IFN-γ signaling in T cells contributes to the development of malaria-associated lung pathology

  lungs pbnk65-infected cell-specific lung flow time-series qrt-pcr