Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 20

System / cell line: gene ✕ Assay: microdissection ✕ Clear

Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.

PMID 19812696 · PMC2754338 · PloS one · 2009 · 8 claims · 5 setups

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Comparison of tumor, transgenic, and non-transgenic lung cells reveals distinct and overlapping regulatory gene networks associated with progression to adenocarcinoma.

lung gene differentially significantly laser histology principal
Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases.

PMID 18842138 · PMC2760875 · Genome biology · 2008 · 8 claims · 6 setups

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AD-related genes (APOE, A2M, PON2, MAP4) and CVD-associated genes (COMT, CBS, WNK1) congregate in a single co-expression module, linking AD and CVD at the transcriptional level

entorhinal subjects expression differentially microarray significance principal
Heterogeneity of p53 mutational status in esophageal squamous cell carcinoma.

PMID 9617346 · PMC5921814 · Japanese journal of cancer research : Gann · 1998 · 6 claims · 4 setups

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Three of 10 esophageal squamous cell carcinomas showed heterogeneous p53 mutational status, but only within the pre-invasive (carcinoma in situ) area.

esophageal paraffin-embedded genomic biotinylated immunohistochemistry microdissection nested
Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas.

PMID 19138956 · PMC3369271 · Cancer prevention research (Philadelphia, Pa.) · 2008 · 8 claims · 4 setups

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EGFR mutations and protein overexpression are early phenomena in the pathogenesis of lung adenocarcinoma, occurring in histologically normal bronchial/bronchiolar epithelium (NBE)

lung microdissection fluorescence immunohistochemistry
Heterogeneity of p53 mutational status in intramucosal carcinoma of the colorectum.

PMID 11223545 · PMC5926696 · Japanese journal of cancer research : Gann · 2001 · 7 claims · 4 setups

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p53 gene mutations occur and diverge at the intramucosal carcinoma stage, before submucosal invasion

endoscopically same pcr-based immunohistochemistry histologic
B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection.

PMID 11299060 · PMC30712 · Arthritis research · 2001 · 8 claims · 4 setups

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70 rearranged heavy chain VH genes from AS synovial membrane were characterized; 59 were potentially functional

frozen lymphocytes microdissected pcr double microdissection semi-nested
Wx: a neural network-based feature selection algorithm for transcriptomic data.

PMID 31324856 · PMC6642261 · Scientific reports · 2019 · 8 claims · 8 setups

Has reproduction · 50

The Wx algorithm ranks genes by a discriminative index (DI) score representing classification power for distinguishing given groups, enabling intuitive selection of optimal biomarker genes.

tcga melanoma lung head bulk single-cell rna-seq
Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma.

PMID 16707008 · PMC1483898 · BMC cancer · 2006 · 6 claims · 4 setups

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Somatic VHL gene alterations (LOH and mutation) may contribute to pathogenesis of MEN2A-associated MTC, similar to their role in MEN2 pheochromocytoma

microdissected same genomic frozen microsatellite loss vhl
Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients.

PMID 17626639 · PMC1952070 · BMC cancer · 2007 · 7 claims · 4 setups

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EGFR mutations (exon 19 deletions, exon 21 L858R) did not correlate with gefitinib response in this cohort

microdissected formalin-fixed archival clinical pcr fluorescence laser
A European focus on proteomics.

PMID 15128441 · PMC416463 · Genome biology · 2004 · 8 claims · 8 setups

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MALDI-MS and ESI-MS are complementary techniques that identify overlapping but distinct subsets of proteins

ribosomal breast ovarian prostate maldi-ms laser-capture fticr-ms
Colocalization and potential interactions of Endozoicomonas and chlamydiae in microbial aggregates of the coral Pocillopora acuta.

PMID 37196086 · PMC11809670 · Science advances · 2023 · 8 claims · 8 setups

Has reproduction · 85

CAMAs are located in the epidermis of the tentacle tips of P. acuta polyps

pocillopora acuta lcm-isolated whole-mount fish transmission
Fingerprinting cancer development.

PMID 14694892 · PMC1241638 · Environmental health perspectives · 2003 · 8 claims · 6 setups

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Protein microarrays can detect phosphoprotein fingerprints that identify early-stage cancer or monitor drug toxicity.

prostate blood model genes microarray proteomic gene
The diagnosis and management of pre-invasive breast disease: promise of new technologies in understanding pre-invasive breast lesions.

PMID 14580250 · PMC314415 · Breast cancer research : BCR · 2003 · 8 claims · 8 setups

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ADH and ductal carcinoma in situ (DCIS) are precursor lesions molecularly similar to adjacent invasive breast cancer

locally adh brca1 malignant array chromosome-based cdna
A big circuit model.

PMID 12940284 · PMC1316925 · Environmental health perspectives · 2003 · 8 claims · 8 setups

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In early prostate carcinogenesis, apoptosis signals are primarily suppressed rather than growth rate being increased.

prostate blood model genes microarray proteomic gene
High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.

PMID 16432260 · PMC1345698 · Nucleic acids research · 2006 · 8 claims · 5 setups

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A 96-well high-throughput bisulfite modification (HTBM) method was developed and validated against single-sample bisulfite modification (SSBM), producing comparable methylation results even from as little as 3 ng DNA.

genomic normal advanced bisulfite-treated methylation-specific bisulfite snp
Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target.

PMID 17912529 · PMC4876910 · World journal of urology · 2007 · 8 claims · 8 setups

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Activating FGFR3 mutations occur frequently in bladder cancer and are strongly associated with low tumour grade and stage

bladder normal urothelial mutation allele-specific laser
Novel approaches for identifying target antigens of autoreactive human B and T cells.

PMID 19763575 · PMC2845891 · Seminars in immunopathology · 2009 · 8 claims · 8 setups

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CD8+ T cells infiltrating MS brain and IM muscle tissue show clonal expansions consistent with antigen-driven selection

muscle brain morphologically autopsy cdr3-spectratyping single-cell immunohistochemistry
Squamous morules are functionally inert elements of premalignant endometrial neoplasia.

PMID 19180120 · PMC2633489 · Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009 · 8 claims · 5 setups

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Squamous morules are hormonally incompetent, lacking ER/PR expression and proliferative activity, unlike the glandular component

endometrial ein microdissected morule-bearing immunohistochemistry laser retrospective
The role of MYH and microsatellite instability in the development of sporadic colorectal cancer.

PMID 17031395 · PMC2360566 · British journal of cancer · 2006 · 8 claims · 8 setups

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MYH-associated colorectal cancers can develop through either a chromosomal instability pathway or a microsatellite instability (MSI) pathway, contradicting the assumption that these are mutually exclusive.

lymphocyte colorectal tumour msi-positive pcr restriction microsatellite
Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach.

PMID 17262083 · PMC2360051 · British journal of cancer · 2007 · 8 claims · 6 setups

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C-Ca is associated with a significantly higher incidence of differentiated-type tumours and lymphatic vessel invasion (LVI) compared with D-Ca

resected c-ca microdissected formalin-fixed histopathological immunohistochemistry pcr-single-strand

Experiments

Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.

Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases.

Heterogeneity of p53 mutational status in esophageal squamous cell carcinoma.

Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas.

Heterogeneity of p53 mutational status in intramucosal carcinoma of the colorectum.

B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection.

Wx: a neural network-based feature selection algorithm for transcriptomic data.

Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma.

Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients.

A European focus on proteomics.

Colocalization and potential interactions of Endozoicomonas and chlamydiae in microbial aggregates of the coral Pocillopora acuta.

Fingerprinting cancer development.

The diagnosis and management of pre-invasive breast disease: promise of new technologies in understanding pre-invasive breast lesions.

A big circuit model.

High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.

Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target.

Novel approaches for identifying target antigens of autoreactive human B and T cells.

Squamous morules are functionally inert elements of premalignant endometrial neoplasia.

The role of MYH and microsatellite instability in the development of sporadic colorectal cancer.

Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach.