Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity.

  PMID 41851118 · PMC13153255 · Nature communications · 2026 · 8 claims · 7 setups

  Full-text index only

  BAP1 (PR-DUB catalytic subunit) restricts pervasive, genome-wide H2AK119ub1 accumulation in mouse oocytes

  zygotes oocytes fgo fgos microinjection bulk western

• Pre-implantation embryo metabolism identified by PEMA reveals endogenous lactate insufficiency contributes to pre-implantation development arrest.

  PMID 42272466 · PMC13247451 · Fundamental research · 2026 · 6 claims · 7 setups

  Has reproduction

  PEMA, a computational tool that weights metabolic reactions using Ribo-seq data combined with RNA-seq-derived flux balance analysis, can characterize metabolic states of human and mouse pre-implantation embryos more precisely than existing methods like Compass.

  embryos pre-implantation ch3pn single-embryo immunofluorescence single-cell