Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation.
PMID 18722178 · PMC3003864 · Molecular cell · 2008 · 7 claims · 8 setups
RBP2 target promoters separate into two functionally distinct classes: differentiation-independent genes (mitochondrial function, RNA/DNA metabolism) and differentiation-dependent genes (cell cycle)
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The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer.
PMID 40981426 · PMC12877753 · Cancer discovery · 2026 · 8 claims · 7 setups
FOLFIRI-resistant PDX tumors show transcriptional upregulation of innate immunity and mitochondrial metabolism genes and reduced expression of DNA polymerase POLD1
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Has reproduction · 50
Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation.
PMID 30561326 · PMC6307859 · eLife · 2018 · 7 claims · 8 setups
Yap1 knockout (KO) ESCs undergo massive, caspase-dependent cell death upon exiting self-renewal (LIF withdrawal), while self-renewing KO cells are unaffected.
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Single-cell resolution of an open chromatin signature in persister tumor cells.
PMID 41485222 · PMC12978573 · Cell reports · 2026 · 8 claims · 8 setups
Single-nucleus multi-omic (snRNA-seq + snATAC-seq) profiling of fallopian tube, treatment-naive, and NACT-treated HGSOC tissue identifies a persister cell signature (PCS) defining the chemotherapy-tolerant state.