Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.

  PMID 41673882 · PMC13047816 · Journal of orthopaedic surgery and research · 2026 · 8 claims · 8 setups

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  Effector CD8+ memory T (Tem) cells are significantly elevated in AS patients compared to healthy controls

  bone peripheral effector interspinous single-cell cibersortx cell-cell

• Novel approaches for mechanistic understanding and predicting preeclampsia.

  PMID 19836839 · PMC2790420 · Journal of reproductive immunology · 2009 · 8 claims · 6 setups

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  The classic two-stage hypothesis (Stage I poor placental perfusion causing Stage II maternal symptoms) needs reevaluation because reduced perfusion alone may be insufficient to cause PE.

  maternal il-10-deficient first-trimester third-trimester surgical seldi-tof genetic

• scTWAS: a powerful statistical framework for single-cell transcriptome-wide association studies.

  PMID 41820391 · PMC13121454 · Nature communications · 2026 · 8 claims · 5 setups

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  scTWAS uses a latent-variable expression-measurement model combined with a moment-based regression to more accurately estimate genetic regulation of gene expression from single-cell data, improving GReX prediction across cell types and datasets

  onek1k-derived onek1k-based immune brain simulated two-sample stage

• Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris.

  PMID 41657309 · PMC12892907 · JCI insight · 2026 · 8 claims · 6 setups

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  A custom KRT5-directed segmentation pipeline improves transcript assignment accuracy in the spatially complex sebaceous gland compared with standard multimodal or nuclei-expansion segmentation

  skin inflammatory tert gtrd spatial immunohistochemistry reanalysis

• Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBP(+) myeloid cells.

  PMID 41928282 · PMC13169754 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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  Peripheral CNBP+ monocytes are expanded and show elevated 'inflammatory response' pathway scores in arthritis patients

  peripheral blood synovial arthritis single-cell bulk immunofluorescence

• Tree shrew immune cell atlas identifies NR1H3⁺ tissue macrophages with conserved anti-inflammatory function.

  PMID 41957356 · PMC13223331 · Nature communications · 2026 · 8 claims · 8 setups

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  A single-cell/single-nucleus RNA-seq atlas across 12 tree shrew tissues identifies 39 distinct immune and non-immune cell types, providing a reference resource for tree shrew immunology

  tree single-cell scrna-seq cross-species functional

• Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue.

  PMID 41261284 · PMC12715258 · EMBO reports · 2025 · 8 claims · 8 setups

  Has reproduction · 78

  Imbalanced sympathetic/thermogenic activation (via UCP1 deficiency or pharmacological futile thermogenesis) causes BAT inflammation, fibrosis and degeneration

  bat wild-type brown histology qrt-pcr norepinephrine

• Single-cell transcriptomics reveals keratinocyte dynamic processes associated with S100a4 expression in psoriasiform dermatitis.

  PMID 41660613 · PMC12876221 · Frontiers in immunology · 2025 · 7 claims · 8 setups

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  S100a4 knockout mice show significant pathological improvement in psoriasis-like lesions, including reduced inflammatory cell infiltration and decreased epidermal hyperplasia

  c57bl skin dorsal dcmo crispr western imiquimod-induced

• Loss of fungal sensing exacerbates liver injury in a murine model of MASLD.

  PMID 41805789 · PMC13135407 · JCI insight · 2026 · 8 claims · 8 setups

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  Patients with advanced liver fibrosis exhibit distinct gut mycobiota profiles, with the genus Penicillium notably reduced in severe fibrosis

  fecal wild-type gut card9 16s random diet-induced

• Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation.

  PMID 41891295 · PMC13022946 · European journal of immunology · 2026 · 8 claims · 7 setups

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  Pam2ODN pretreatment reduces airway Th2 polarization and eosinophilic inflammation without affecting Th1, Th17, or Treg responses

  balf lung mediastinal facs-sorted flow bulk scrna-seq

• Niacin promotes motor function recovery after spinal cord injury via Hcar2-dependent microglia immunometabolic regulation.

  PMID 42068080 · PMC13135113 · Clinical and translational medicine · 2026 · 8 claims · 8 setups

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  Hcar2 is a microglia-enriched gene whose spinal cord expression is upregulated after SCI, peaking at 7 days post-injury

  spinal c57bl bv2 single-cell bulk sci

• Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.

  PMID 34795257 · PMC8602323 · Nature communications · 2021 · 8 claims · 12 setups

  Has reproduction · 67

  PYK2 was identified as a putative IRF5 kinase via a kinase inhibitor library screen in macrophages

  raw264.7 hektlr4 hoxb8-derived colon kinase co-immunoprecipitation co-ip

• Expanding the vision of environmental health at UNC-CH.

  PMID 15248304 · PMC1247395 · Environmental health perspectives · 2004 · 8 claims · 8 setups

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  Human breast tumors arise from at least two distinct cell types, basal and luminal epithelial, with different clinical behavior

  breast chinese carolina rodent microarray functional genetic

• scMILD: Single-cell multiple instance learning for sample classification and associated subpopulation discovery.

  PMID 41907409 · PMC13019583 · iScience · 2026 · 8 claims · 8 setups

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  scMILD identifies condition-associated cells using only sample-level labels via a dual-branch MIL architecture with a shared encoder

  simulated lupus covid-19 ulcerative simulated mixture scrna-seq

• Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention.

  PMID 20400112 · PMC2907433 · The Journal of surgical research · 2011 · 8 claims · 8 setups

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  ROS/RNS generated during hepatic ischemia/reperfusion cause cellular damage via mitochondrial dysfunction, ATP depletion, ion disturbances, and membrane/lysosomal disruption

  inos enos enos-overexpressing orthotopic genetic transgenic clinical

• ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis.

  PMID 41264461 · PMC13017563 · Cardiovascular research · 2026 · 8 claims · 7 setups

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  Non-haematopoietic (vascular) ChemR23 deficiency increases atherosclerotic lesion size and enhances VSMC proliferation and VSMC-derived foam cell formation

  apoe adventitia-stripped advanced aortic atherosclerotic bulk single-cell

• Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

  PMID 41800251 · PMC12965062 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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  TMZ enhances mitochondrial membrane potential and suppresses fatty acid oxidation (FAO) in human T cells

  peripheral endoc-βh5 nod pancreatic mitochondrial extracellular glucose-stimulated

• Highlights of international conference of immunogenomics and immunomics, October 8-12, 2006 Budapest, Hungary.

  PMID 17470366 · PMC7130317 · Cellular immunology · 2006 · 8 claims · 8 setups

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  An 'immunological constant of rejection' involving interferon-stimulated genes (ISGs) and innate immune effector functions (IEF) underlies diverse immune-mediated tissue destruction processes (allograft rejection, cancer rejection, autoimmunity, infection)

  hla-b44 plasma macrophages complement proteomics shotgun cap

• Addressing the age-old question of old age.

  PMID 15287970 · PMC507873 · Genome biology · 2004 · 8 claims · 6 setups

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  Dietary restriction and reduced temperature extend Drosophila lifespan via intrinsically different demographic mechanisms: dietary restriction lowers intrinsic frailty, while lower temperature reduces the rate of senescence.

  drosophila populations australian centenarians demographic historical peptide

• Microglia maintain structural integrity during fetal brain morphogenesis.

  PMID 38309258 · PMC10869139 · Cell · 2024 · 8 claims · 8 setups

  Has reproduction · 68

  Embryonic ATM-like microglia accumulate at two fetal cortical boundaries, the cortico-striato-amygdalar boundary (CSA) and cortico-septal boundary (CSB), resembling post-natal axon-tract-associated microglia (ATM)

  embryonic cx3cr1 fetal embryos single-cell immunolabeling phrodo