Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
-
Full-text index only
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
PMID 18267968 · PMC2367719 · Nucleic acids research · 2008 · 6 claims · 8 setups
The seed arm (guide strand positions 2-8), its complementary passenger-strand sequence, the 5' end of the guide strand, and the 3' overhang of the passenger strand can be simultaneously replaced with DNA without substantial loss of gene-silencing activity.
-
Full-text index only
Proteomic revelation: SUMO changes partners when the heat is on.
PMID 19638612 · PMC2825085 · Science signaling · 2009 · 8 claims · 4 setups
A quantitative, system-wide MS approach combining TAP-SUMO-2 purification and triple-SILAC labeling reveals dynamic changes in SUMO-2 modification during heat shock and recovery
-
Full-text index only
Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.
PMID 18683930 · PMC2649877 · Journal of the American Chemical Society · 2008 · 7 claims · 5 setups
Y289L GalT-mediated transfer of UDP-GalNAz followed by Cu(I)-catalyzed azide-alkyne cycloaddition enables selective, highly sensitive fluorescent/biotin labeling of O-GlcNAc-modified proteins
-
Full-text index only
Unraveling the histone's potential: a proteomics perspective.
PMID 18849650 · PMC2662511 · Epigenetics · 2008 · 8 claims · 8 setups
Mass spectrometry can determine the full repertoire of histone PTMs, their residue-specific location, and combinatorial patterns without requiring prior knowledge of the modification, unlike antibody-based methods