Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Heterozygous ADAR mutant mice exhibit RNA sensing-dependent neuroinflammation and phenotypes associated with Aicardi-Goutières syndrome.

  PMID 41704749 · PMC12907846 · iScience · 2026 · 8 claims · 8 setups

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  A heterozygous Adar G1007R (mouse G956R/G567) mouse model recapitulates the genetic and inflammatory features of human ADAR G1007R AGS patients

  brain computational coronal adar1 real-time bulk ingenuity

• Arabidopsis RBV is a conserved WD40 repeat protein that promotes microRNA biogenesis and ARGONAUTE1 loading.

  PMID 35260568 · PMC8904849 · Nature communications · 2022 · 7 claims · 8 setups

  Has reproduction · 55

  RBV, a WD40 repeat protein, is required for global microRNA biogenesis in Arabidopsis

  amir-sul col 14-day-old arabidopsis small rna-seq gel

• The Li2 mutation results in reduced subgenome expression bias in elongating fibers of allotetraploid cotton (Gossypium hirsutum L.).

  PMID 24598808 · PMC3944810 · PloS one · 2014 · 8 claims · 7 setups

  Has reproduction · 58

  The Li2 mutation significantly reduces subgenome (homeolog) expression bias in the elongating fiber transcriptome.

  developing rna-seq expressed subgenome-biased paired-end rna-seq rt-qpcr

• Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA.

  PMID 19706770 · PMC2745517 · Cancer research · 2009 · 8 claims · 8 setups

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  Genome-wide DNA copy number analysis of 161 primary breast tumors identified six novel focally amplified genes: POLD3, IRAK4, IRX2, TBL1XR1, ASPH, and BRD4

  breast mcf10a mcf10ca1h snp quantitative rt-qpcr

• Stem cell-associated osteogenic deficiency causes craniofacial deformities with progeroid accumulation of prelamin A.

  PMID 41632539 · PMC13041684 · JCI insight · 2026 · 8 claims · 8 setups

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  Lmna L648R mutation causes multiple suture craniosynostosis (AF, PF, COR) occurring under low bone density, contrasting with conventional synostosis caused by excessive ossification

  skull calvarial suture p7-p10 micro-ct h&e brdu

• Expression analysis of candidate breast tumour suppressor genes on chromosome 16q.

  PMID 16280054 · PMC1410740 · Breast cancer research : BCR · 2005 · 8 claims · 7 setups

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  None of the six candidate genes (CBFA2T3, TERF2, TERF2IP, FBXL8, LRRC29, FANCA) showed inactivating mutations or expression differences clearly associated with 16q LOH status

  breast quantitative fragment gene-expression

• Enhanced microRNA accumulation and gene silencing efficiency through optimized precursor base pairing.

  PMID 41505763 · PMC12782649 · The Plant journal : for cell and molecular biology · 2026 · 8 claims · 7 setups

  Has reproduction · 87

  Introducing a G-C base pair immediately upstream of the mature amiRNA (position 18, A18G) at the DCL1 first cleavage site significantly enhances amiRNA accumulation and silencing efficiency

  nicotiana arabidopsis srna quantitative chlorophyll

• An NSP2-MYB module orchestrates flavonoid biosynthesis and nodule symbiosis.

  PMID 41643674 · PMC7619063 · Current biology : CB · 2026 · 8 claims · 8 setups

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  NSP1 and NSP2 promote expression of flavonoid biosynthesis genes during nutrient starvation and rhizobial symbiosis in Medicago truncatula

  medicago nicotiana recombinant yeast rna-seq qpcr targeted

• Evaluating sequence data quality from the Swift Accel-Amplicon CFTR Panel.

  PMID 31913291 · PMC6949293 · Scientific data · 2020 · 6 claims · 7 setups

  Has reproduction · 89

  The Accel-Amplicon CFTR panel generates sequencing data with high coverage depth and near 100% on-target reads.

  genomic adapted aligned pcr amplicon multiplex qpcr

• Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.

  PMID 34643182 · PMC8555986 · eLife · 2021 · 7 claims · 8 setups

  Has reproduction · 84

  Tbx5 directly maintains Aldh1a2 expression in the foregut lateral plate mesoderm via an evolutionarily conserved intronic enhancer

  e9.5 xenopus bulk rt-qpcr whole-mount

• 5-methylcytosine RNA modification regulators-based patterns and features of immune microenvironment in acute myeloid leukemia.

  PMID 38277218 · PMC10911375 · Aging · 2024 · 8 claims · 8 setups

  Has reproduction · 93

  m5C regulators are differentially expressed between AML and normal samples and correlate with AML prognosis

  tcga aml gse12417 bulk mutation methylation

• Deubiquitination enzyme USP35 negatively regulates MAVS signaling to inhibit anti-tumor immunity.

  PMID 40016186 · PMC11868397 · Cell death & disease · 2025 · 8 claims · 8 setups

  Has reproduction · 81

  USP35 interacts with MAVS and removes its K63-linked polyubiquitin chains, inhibiting viral-induced MAVS-TBK1-IRF3 activation and downstream inflammatory gene expression

  tumor melanoma tcga-skcm hek293t bioinformatics geo kaplan-meier

• Targeting the epigenome and the integrated stress response to normalize colorectal cancer subclonal plasticity and progression.

  PMID 41963303 · PMC13181133 · Cell death & disease · 2026 · 8 claims · 8 setups

  Has reproduction · 68

  The integrated stress response (ISR) induces CRC cell plasticity, subclonal diversity, and tumor progression in stress-surviving cells

  ht29-derived ht29 nod rna-seq faire-qpcr chip-seq

• MerTK-triggered TGFβ1 autocrine signal regulates microglial response to neurodegeneration.

  PMID 41634038 · PMC12976283 · Nature communications · 2026 · 8 claims · 8 setups

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  Microglial response to pathological axonal degeneration (optic nerve injury) depends on the phagocytic receptor MerTK

  optic facs-sorted microglia co-immunostaining qpcr bulk

• Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk RNA-seq analyses.

  PMID 38482016 · PMC10933018 · Frontiers in immunology · 2024 · 8 claims · 8 setups

  Has reproduction · 80

  C3 PLP2+ Tumor Epithelial Progenitor Cells are a noteworthy subpopulation exerting a pivotal influence on CC differentiation and progression

  cervical tcga siha scrna-seq bulk rt-qpcr

• Cohesin regulates alternative splicing.

  PMID 36857449 · PMC9977177 · Science advances · 2023 · 7 claims · 8 setups

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  Cohesin regulates alternative splicing independently of its effects on transcription.

  hct116rmac hct116 recombinant hek293 bulk rt-pcr proximity

• Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.

  PMID 41606307 · PMC12945694 · Nature metabolism · 2026 · 8 claims · 8 setups

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  Lamin A/C represses cysteine biosynthesis and catabolism in naive mES cells by suppressing CTH and CBS

  mes metabolomics atac-seq chip-qpcr

• Development and validation of a gemcitabine sensitivity-related long noncoding RNA signature for predicting the prognosis and subtypes of bladder cancer.

  PMID 41809777 · PMC12968932 · Translational andrology and urology · 2026 · 8 claims · 8 setups

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  A 37-GSRlncRNA prognostic signature stratifies BLCA patients into low- and high-risk groups with significant differences in survival, pathway enrichment, immune infiltration, and mutational profiles

  tcga-blca blca paired wgcna differential machine

• Genomic Landscape Analysis of Canine Pulmonary Adenocarcinoma Reveals Candidate Targetable Gene Fusions.

  PMID 41914575 · PMC13161739 · Veterinary and comparative oncology · 2026 · 8 claims · 7 setups

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  STAR-Fusion identified 26 gene fusions in 19 of 36 (53%) cPAC tumours with RNA-seq data

  cpac matched sdc4 rna-seq whole-genome whole-exome

• Gene expression study on peripheral blood identifies progranulin mutations.

  PMID 18551524 · PMC2773201 · Annals of neurology · 2008 · 7 claims · 3 setups

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  PGRN is highly expressed in peripheral blood (97th percentile of all array genes)

  peripheral blood-derived microarray direct real-time