Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments.

  PMID 18765474 · PMC2577354 · Nucleic acids research · 2008 · 6 claims · 6 setups

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  Extensive sonication reduces crosslinked chromatin to an average fragment size of ~200 bp (range 75–300 bp) and fragmentation is largely random with respect to genomic region and nucleosome position.

  cerevisiae hela chip-qpcr nucleosome gel

• An MNase-ChIP-Seq Protocol to Profile Histone Modifications at a DNA Break in Yeast.

  PMID 41874159 · PMC13010634 · Methods and protocols · 2026 · 6 claims · 5 setups

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  MNase-ChIP-seq, combining MNase-based chromatin fragmentation with ChIP and NGS, is a robust protocol to map histone PTMs and their genome-wide distribution after induction of a single HO-generated DSB in yeast

  cerevisiae extracted crosslinked rt-qpcr qpcr-based mnase-chip-seq